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| 2. |
- Matsuura, M., et al.
(författare)
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Herschel Detects a Massive Dust Reservoir in Supernova 1987A
- 2011
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 333:6047, s. 1258-1261
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Tidskriftsartikel (refereegranskat)abstract
- We report far-infrared and submillimeter observations of supernova 1987A, the star whose explosion was observed on 23 February 1987 in the Large Magellanic Cloud, a galaxy located 160,000 light years away. The observations reveal the presence of a population of cold dust grains radiating with a temperature of about 17 to 23 kelvin at a rate of about 220 times the luminosity of the Sun. The intensity and spectral energy distribution of the emission suggest a dust mass of about 0.4 to 0.7 times the mass of the Sun. The radiation must originate from the supernova ejecta and requires the efficient precipitation of all refractory material into dust. Our observations imply that supernovae can produce the large dust masses detected in young galaxies at very high redshifts.
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| 4. |
- Babakinejad, Babak, et al.
(författare)
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Local delivery of molecules from a nanopipette for quantitative receptor mapping on live cells
- 2013
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 1520-6882 .- 0003-2700. ; 85:19, s. 42-9333
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Tidskriftsartikel (refereegranskat)abstract
- Using nanopipettes to locally deliver molecules to the surface of living cells could potentially open up studies of biological processes down to the level of single molecules. However, in order to achieve precise and quantitative local delivery it is essential to be able to determine the amount and distribution of the molecules being delivered. In this work, we investigate how the size of the nanopipette, the magnitude of the applied pressure or voltage, which drives the delivery, and the distance to the underlying surface influences the number and spatial distribution of the delivered molecules. Analytical expressions describing the delivery are derived and compared with the results from finite element simulations and experiments on delivery from a 100 nm nanopipette in bulk solution and to the surface of sensory neurons. We then developed a setup for rapid and quantitative delivery to multiple subcellular areas, delivering the molecule capsaicin to stimulate opening of Transient Receptor Potential Vanilloid subfamily member 1 (TRPV1) channels, membrane receptors involved in pain sensation. Overall, precise and quantitative delivery of molecules from nanopipettes has been demonstrated, opening up many applications in biology such as locally stimulating and mapping receptors on the surface of live cells.
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| 6. |
- Indriolo, Nick, et al.
(författare)
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High Spectral Resolution Observations toward Orion BN at 6 μm: No Evidence for Hot Water
- 2018
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 865:2
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Tidskriftsartikel (refereegranskat)abstract
- The Becklin-Neugebauer (BN) object in Orion has a large proper motion and radial velocity with respect to the gas and other stars in the region where it is presumed to have formed. Multiple dynamical interaction scenarios have been proposed to explain this motion. In one case BN is thought to have interacted with stars in the Trapezium cluster, while in another it is thought to have interacted with source I while deeply embedded in molecular gas. If there is dense gas that has been retained in close proximity to BN, it may be evidence that the latter scenario is favored. We observed BN at high spectral resolution in three windows near 6 mu m using the Echelon-Cross-Echelle Spectrograph on board the Stratospheric Observatory for Infrared Astronomy targeting the nu(2) vibrational band of H2O. Absorption from only three transitions of H2O is detected, and through kinematic analysis is associated with cool, dense foreground gas, not BN itself. We find no evidence for H2O absorption or emission at the systemic velocity of BN.
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| 7. |
- Meixner, Margaret, et al.
(författare)
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Herschel and ALMA measurements of dust and molecules in supernova 1987A
- 2013
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Ingår i: Proceedings of Science. - 1824-8039. ; Part F113823
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Konferensbidrag (refereegranskat)abstract
- Dust production by supernovae is important in the dust life cycle of a galaxy. The explosion of SN 1987A was the nearest SN detected in the last 400 years, allowing us detailed studies of contemporary evolution of a supernova for the first time. In 2011, Matsuura et al. reported 0.4-0.7 M of dust in SN 1987A based on Herschel HERITAGE survey data, which is surprisingly large compared to prior measurements of supernovae. In this paper, we present our follow-up studies of this important discovery about SN 1987A using the Herschel Space Observatory and the Atacama Large Millimeter Array (ALMA). We highlight two important results, the detection of cold molecular gas and dust in the ejected material of SN 1987A. Our results suggest that SNe are significant producers of dust and molecules, as well as heavy elements, driving chemical evolution of galaxies.
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| 8. |
- Mora, Pablo, et al.
(författare)
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Satellitome Analysis in the Ladybird Beetle Hippodamia variegata(Coleoptera, Coccinellidae)
- 2020
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Ingår i: Genes. - : MDPI. - 2073-4425. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- Hippodamia variegatais one of the most commercialized ladybirds used for the biological control of aphid pest species in many economically important crops. This species is the first Coccinellidae whose satellitome has been studied by applying new sequencing technologies and bioinformatics tools. We found that 47% of theH. variegatagenome is composed of repeated sequences. We identified 30 satellite DNA (satDNA) families with a median intragenomic divergence of 5.75% and A+T content between 45.6% and 74.7%. This species shows satDNA families with highly variable sizes although the most common size is 100-200 bp. However, we highlight the existence of a satDNA family with a repeat unit of 2 kb, the largest repeat unit described in Coleoptera. PCR amplifications for fluorescence in situ hybridization (FISH) probe generation were performed for the four most abundant satDNA families. FISH with the most abundant satDNA family as a probe shows its pericentromeric location on all chromosomes. This location is coincident with the heterochromatin revealed by C-banding and DAPI staining, also analyzed in this work. Hybridization signals for other satDNA families were located only on certain bivalents and the X chromosome. These satDNAs could be very useful as chromosomal markers due to their reduced location.
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| 10. |
- Selvaraj, Sudhakar, et al.
(författare)
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Early screening for post-stroke depression, and the effect on functional outcomes, quality of life and mortality : a protocol for a systematic review and meta-analysis
- 2021
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 11:8
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Forskningsöversikt (refereegranskat)abstract
- Introduction: Post-stroke depression (PSD) is a severe complication of cerebrovascular stroke affecting about one-third of stroke survivors. Moreover, PSD is associated with functional recovery and quality of life (QOL) in stroke survivors. Screening for PSD is recommended. There are, however, differences in the literature on the impact of early screening on functional outcomes. In this systematic review, we synthesise the currently available literature regarding the associations between timing and setting of PSD screening and mortality, QOL and functional outcomes in stroke survivors.Methods and analysis: We will systematically search electronic databases including PubMed, Embase, APA PsycINFO, Web of Science, Scopus and CINAHL from inception to August 2021. Four reviewers will screen the title and abstract and full-text level records identified in the search in a blinded fashion to determine the study eligibility. Any selection disagreements between the reviewers will be resolved by the study investigator. Data extraction of eligible studies will be conducted by two reviewers using a predefined template. We will complete the quality assessment of included articles independently by two reviewers using the Newcastle Ottawa Scale. Eventual discrepancies will be resolved by the principal investigator.Ethics and dissemination: Due to the nature of the study design, ethical approval is not required. The systematic review and meta-analysis findings will be published and disseminated in a peer-reviewed journal. Our results will also be disseminated through posters and presentations at appropriate scientific conferences.PROSPERO registration number: CRD42021235993.
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