| 1. |
- Berry, Teeara, et al.
(författare)
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The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
- 2012
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Ingår i: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 22:1, s. 117-130
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Tidskriftsartikel (refereegranskat)abstract
- The ALK(F1174L) mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model overexpressing ALK(F1174L) in the neural crest. Compared to ALKF1174L and MYCN alone, co-expression of these two oncogenes led to the development of neuroblastomas with earlier onset, higher penetrance, and enhanced lethality. ALK(F1174L)/MYCN tumors exhibited increased MYCN dosage due to ALK(F1174L)-induced activation of the PI3K/AKT/mTOR and MAPK pathways, coupled with suppression of MYCN pro-apoptotic effects. Combined treatment with the ATP-competitive mTOR inhibitor Torin2 overcame the resistance of ALK(F1174L)/MYCN tumors to crizotinib. Our findings demonstrate a pathogenic role for ALK(F1174L) in neuroblastomas overexpressing MYCN and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma.
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| 2. |
- Katsivalis, Ioannis, 1986, et al.
(författare)
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Fatigue performance and damage characterisation of ultra-thin tow-based discontinuous tape composites
- 2024
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Ingår i: Composites Part B: Engineering. - : Elsevier Ltd. - 1359-8368 .- 1879-1069. ; 281
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Tidskriftsartikel (refereegranskat)abstract
- Tow-based discontinuous composites are an attractive alternative material to conventional continuous composites as they offer in-plane isotropy, enhanced manufacturability allowing to achieve complex 3D shapes with high curvatures and local reinforcement in critical areas, while also maintaining high strength and stiffness, therefore expanding the design space significantly. In addition, the use of ultra-thin tapes and optimised manufacturing methods can increase the mechanical properties even further and change the damage mechanisms. Fatigue, however, could be a limiting design factor, as the fatigue behaviour of these materials has not been fully characterised. This work presents a complete study on the fatigue response of ultra-thin tow-based discontinuous composites: fatigue S–N curves are measured, and the damage and failure mechanisms are characterised utilising optical and scanning electron microscopy. Finally, a critical interpretation of the results is also presented by comparing the performance of ultra-thin tow-based discontinuous composites against other similar fibre reinforced composites and metals. It is shown that the optimised manufacturing methods combined with low tape thickness leads to enhanced quasi-isotropic fatigue performance. In addition, the fatigue limit was raised significantly compared to other discontinuous composites, and the tow-based discontinuous composites outperformed their metal counterparts when the results were normalised with density.
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| 3. |
- Katsivalis, Ioannis, 1986, et al.
(författare)
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Strength analysis and failure prediction of thin tow-based discontinuous composites
- 2024
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Ingår i: Composites Science And Technology. - : Elsevier BV. - 0266-3538 .- 1879-1050. ; 245
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Tidskriftsartikel (refereegranskat)abstract
- Tow Based Discontinuous Composites (TBDCs) are a new class of composite materials which combine in-plane isotropy, high strength and stiffness and enhanced manufacturability. However, due to their complicated micro-architecture, characterising the performance of these materials and predicting their response is challenging. This work develops a complete experimental and analytical framework which identifies all the key properties in the performance of the TBDCs, characterises them experimentally and builds an analytical predictive tool for both the stiffness response and the strength of the TBDC material. Fractography is also utilised to identify the damage mechanisms and correlate them with the analytical predictions. A parametric study is developed which shows the critical effect that the tape thickness and mode II fracture toughness have on the TBDCs. Finally, the performance of the material is compared to similarly developed TBDCs from the literature and shows the significant strength and stiffness increases recorded through the combination of the thin high-modulus tapes and the increased fibre volume fractions.
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| 4. |
- Loukil, Mohamed Sahbi, 1984-, et al.
(författare)
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EXPERIMENTAL INVESTIGATION ON BEARING BEHAVIOR AND FAILURE MECHANISM OF HYBRID THIN/THICK-PLY COMPOSITE LAMINATES
- 2022
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Ingår i: ECCM 2022 - Proceedings of the 20th European Conference on Composite Materials: Composites Meet Sustainability. - : Composite Construction Laboratory (CCLab), Ecole Polytechnique Federale de Lausanne (EPFL). - 9782970161400 ; , s. 999-1006
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Konferensbidrag (refereegranskat)abstract
- The effect of using thin plies to increase the bearing strength of composite laminates was investigated. Five different composite laminates were manufactured using a single material system with varying proportions of thin plies (100% thick-ply, 50% thin-ply and 100% thin-ply). Bearing tests were performed and the results from the tests are investigated. The results show that performance in terms of bearing strength at onset of damage, and ultimate bearing stress increase proportionally with the increasing amount of thin plies within the stack. Microscopic examination of the failure modes for all laminates was performed at the center of the hole to determine the dominant failure mode. Transition zone was investigated where both thin and thick plies were designed so that the thin plies are used only when more strength is required. © 2022 Loukil et al.
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| 5. |
- Olsson, Robin, 1958, et al.
(författare)
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Design, Manufacture, and Cryogenic Testing of a Linerless Composite Tank for Liquid Hydrogen
- 2024
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Ingår i: Applied Composite Materials. - : Springer Nature. - 1573-4897 .- 0929-189X. ; 31:4, s. 1131-1154
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes design, manufacture, and testing of a linerless composite vessel for liquid hydrogen, having 0.3 m diameter and 0.9 m length. The vessel consists of a composite cylinder manufactured by wet filament winding of thin-ply composite bands, bonded to titanium end caps produced by additive manufacturing. The aim was to demonstrate the linerless design concept with a thin-ply composite for the cylinder. The investigation is limited to the internal pressure vessel, while real cryogenic tanks also involve an outer vessel containing vacuum for thermal insulation. Thermal stresses dominate during normal operation (4 bar) and the layup was selected for equal hoop strains in the composite cylinder and end caps during filling with liquid hydrogen. Two vessels were tested in 20 cycles, by filling and emptying with liquid nitrogen to 4 bar, without signs of damage or leakage. Subsequently, one vessel was tested until burst at almost 30 bar.
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| 6. |
- Sahbi Loukil, Mohamed, et al.
(författare)
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Experimental and numerical investigation on bearing behavior of hybrid thin/thick-ply composite laminates
- 2024
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Ingår i: Composite structures. - : Elsevier Ltd. - 0263-8223 .- 1879-1085. ; 331
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Tidskriftsartikel (refereegranskat)abstract
- Experimental and numerical studies were carried out to characterize hybrid thin- and thick-ply composite laminates and assess modelling capabilities. Five different composite laminates were manufactured using a single material system with varying proportions of thin plies (0%, 50%, and 100% thin-ply). Bearing tests were performed and the results from the tests were investigated. The results showed that performance, in terms of bearing strength at onset of damage and ultimate bearing stress, increased proportionally with the increasing amount of thin plies within the laminate. Microscopic examination of the failure modes for all laminates was performed at the center of the hole to determine the dominant failure mode. The numerical investigation uses a highly detailed mesoscale model previously validated for crash simulations but never used successfully to bearing damage areas. The results showed a good correlation regarding both the load response and the morphology of damage.
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