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Sökning: WFRF:(Morelli Gianluca)

  • Resultat 1-4 av 4
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1.
  • Gentiluomo, Manuel, et al. (författare)
  • Mitochondrial DNA Copy-Number Variation and Pancreatic Cancer Risk in the Prospective EPIC Cohort
  • 2020
  • Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - Philadelphia : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 29:3, s. 681-686
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Mitochondrial DNA (mtDNA) copy number in peripheral blood has been found to be sociated with risk of developing several cancers. However, data on pancreatic ductal adenocarcinoma DAC) are very limited.Methods: To further our knowledge on this topic, we measured relative mtDNA copy number by a antitative real-time PCR assay in peripheral leukocyte samples of 476PDACcases and 357 controls sted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Results: We observed lower mtDNA copy number with advancing age (P = 6.54 x 10(-5)) and with a high dy mass index (BMI) level (P = 0.004) and no association with sex, smoking behavior, and alcohol nsumption. We found an association between increased mtDNA copy number and decreased risk of veloping PDAC with an odds ratios (OR) of 0.35 [95% confidence interval (CI), 0.160.79; P = 0.01] when mparing the fifth quintile with the first using an unconditional logistic regression and an OR of 0.19 5% CI, 0.07-0.52; P = 0.001) with a conditional analysis. Analyses stratified by BMI showed an sociation between high mtDNA copy number and decreased risk in the stratum of normal weight, nsistent with the main analyses.Conclusions: Our results suggest a protective effect of a higher number of mitochondria, measured in ripheral blood leukocytes, on PDAC risk.Impact: Our findings highlight the importance of understanding the mitochondrial biology in pancreatic ncer.
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  • Rajala, Ulla, 1967-, et al. (författare)
  • The Stockholm Volterra Project : exploring a cityscape in an urban context
  • 2018
  • Ingår i: The Archaeology of Death. - Oxford : Archaeopress. - 9781784919214 ; , s. 553-562
  • Konferensbidrag (refereegranskat)abstract
    • This article presents the Stockholm Volterra Project and its developments since 2013. This project, run by Stockholm University and the Department of Archaeology and Classical Studies, has carried out geophysical prospections in Volterra in collaboration with Soprintendenza Archeologia, Belle Arti e Paesaggio per le province di Pisa e Livorno. The aims and methods of the project are outlined together with a closer presentation of key sites from 2014 and 2015: the ‘Football Pitch’, the area in front of the church of San Giusto, the ruined church of Santo Stefano, the amphitheatre and Ortino sites.
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  • Wijayatunga, Priyantha, 1967-, et al. (författare)
  • Discussion on the meeting on 'Data visualization'
  • 2019
  • Ingår i: Journal of the Royal Statistical Society. - UK : Royal Statistical Society. - 0964-1998 .- 1467-985X. ; 182:2, s. 433-441
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Visualizing both conditional and marginal associations in contingency tables by using simple diagrams is discussed
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  • Resultat 1-4 av 4

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