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Träfflista för sökning "WFRF:(Morgan David GA) "

Search: WFRF:(Morgan David GA)

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1.
  • Niemi, MEK, et al. (author)
  • 2021
  • swepub:Mat__t
  •  
2.
  • Kanai, M, et al. (author)
  • 2023
  • swepub:Mat__t
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3.
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4.
  • 2017
  • swepub:Mat__t
  •  
5.
  • Giordanetto, Fabrizio, et al. (author)
  • Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists
  • 2007
  • In: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X. ; 17:15, s. 4232-41
  • Journal article (peer-reviewed)abstract
    • We herein report the optimization of cyclopentane- and cyclohexane-1,3-diamine derivatives as novel and potent MCH-R1 antagonists. Structural modifications of the 2-amino-quinoline and thiophene moieties found in the initial lead compound served to improve its metabolic stability profile and MCH-R1 affinity, and revealed unprecedented SAR when compared to other 2-amino-quinoline-containing MCH-R1 antagonists.
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  • Result 1-5 of 5

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