| 1. |
- Uramoto, Hidetaka, et al.
(författare)
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Expression of deltaNp73 predicts poor prognosis in lung cancer.
- 2004
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Ingår i: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1078-0432. ; 10:20, s. 6905-11
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: DeltaNp73 is an isoform of the p53 homologue p73, which lacks an NH(2)-terminal transactivation domain and antagonizes the induction of gene expression by p53/p73. The aim of this study was to detect DeltaNp73 expression in lung cancer and to evaluate the relationship between the DeltaNp73 expression level and the prognosis of patients with resected lung cancer. EXPERIMENTAL DESIGN: We used immunohistochemistry to analyze the protein expression of DeltaNp73 in paraffin-embedded tumor samples from 132 well-characterized lung cancer patients and compared the expression level of DeltaNp73, clinical variables, and survival outcome. RESULTS: Positive expression of DeltaNp73 was detected mainly in the cytoplasm of tumor cells in 77 of 132 patients (58.3%) with lung cancer. The incidence of positive expression of DeltaNp73 was 52.2, 50.0, and 70.2% in patients with stage I, II, and III, respectively (P = 0.04). Positive expression of DeltaNp73 was associated with gender but not associated with age, histologic type, pathological stage, pathological T status, and pathological N status. Lung cancer patients with positive DeltaNp73 expression had a poorer prognosis than those with negative DeltaNp73 expression. In addition, multivariate analysis of the clinicopathological characteristics of lung cancer indicated that positive expression of DeltaNp73 was a significant independent factor for predicting poor prognosis (P < 0.0001, risk ratio = 3.39). CONCLUSIONS: Expression of DeltaNp73 may be a useful marker for predicting poor prognosis of patients who underwent resection of lung cancer.
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| 2. |
- Mathayan, Vairavel, et al.
(författare)
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Assessing the potential of ion beam analytical techniques for depth profiling Li in thin film Li ion batteries
- 2021
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Ingår i: Journal of Applied Physics. - : American Institute of Physics (AIP). - 0021-8979 .- 1089-7550. ; 130:12
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Tidskriftsartikel (refereegranskat)abstract
- Depth resolution and probing depth for Li in lithium thin film batteries achievable using different ion beam analytical techniques were investigated. Experiments using protons for nuclear reaction analysis, He ions for time-of-flight (TOF) energy elastic recoil detection analysis (ERDA) in transmission geometry, as well as He and Li ions for coincidence ERDA in transmission geometry are performed. Experimental results are compared in terms of the obtained Li concentration in the separator layer. In coincidence ERDA experiments, significant loss of Li-Li and He-Li coincidence counts was observed due to multiple scattering of recoiled/scattered particles in the battery sample. The ideal achievable Li depth resolution was calculated for the ion beam techniques. A depth resolution of 750, 1030, 310, and 510 x 10(15) atoms/cm(2) could be achieved in the Nb2O5 cathode by nuclear reaction analysis (NRA) using 2 MeV H, TOF-ERDA using 8 MeV He, and coincidence ERDA using 8 MeV He and 8 MeV Li ions, respectively, upon optimization of the experimental setup. While a depth resolution of 120 x 10(15) ions/cm(2) could be achieved for Li by conventional TOF-ERDA using an solid-state detector energy detector and light primary ions such as O under gracing incidence, TOF-ERDA experiments are found to produce significantly higher beam damage in batteries than other techniques. The beam damage in NRA and coincidence ERDA as performed in this study is estimated to be of the order of 10(-4) dpa. (C)& nbsp;2021 Author(s).& nbsp; All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license(http://creativecommons.org/licenses/by/4.0/).
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| 3. |
- Mathayan, Vairavel, et al.
(författare)
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In-operando observation of Li depth distribution and Li transport in thin film Li ion batteries
- 2020
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 117:2
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Tidskriftsartikel (refereegranskat)abstract
- A quantitative assessment of Li transport is decisive for Li ion battery research. Here, we demonstrate in situ and in-operando depth profiling of the Li-inventory in lithium thin film batteries. We employ non-destructive coincidence elastic recoil detection analysis using different projectile ions in the MeV range to simultaneously quantify the lithium depth distribution in the whole stack with resolution better than 50nm by simulations of experimental data. Experiments were performed while charging and discharging the stack. 5MeV Li-7 primary ions were employed to extract the Li depth distribution in an similar to 3.6 mu m thick Ti/LMO/LIPON/NbO/Ti thin film battery. To show the versatility of the approach, a coincidence experiment was also performed using 4MeV He ions for an similar to 3.4 mu m thick Ti/LMO/LIPON/NbO/Ti battery. Our results illustrate, for example, lithium accumulation in the 90nm thick NbO layer upon charging with +3V. We could also show the transport of large amounts of Li from the LMO/LIPON interface to the LIPON/NbO interface upon overcharging with +5V. Altogether, these experiments demonstrate the potential of the employed technique, enabling in-operando high resolution composition depth profiling of Li and other light elements (e.g., H, He, C, N, and O) in ultrathin all-solid state batteries.
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| 4. |
- Mathayan, Vairavel, et al.
(författare)
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Sensitive in-operando observation of Li and O transport in thin-film Li-ion batteries
- 2021
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Ingår i: Materials Today Energy. - : Elsevier. - 2468-6069. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- Thin-film batteries often contain oxides in the anode, cathode, and electrolyte materials. In-operando methods capable of Li and O depth profiling are relevant for battery research to study, e.g. diffusion and trapping of constituents. Here, we demonstrate ion beam-based analytical methods with high depth resolution and sensitivity for depth profiling Li and O in thin-film batteries using 10 MeV Li and He ions. Simultaneous depth profiling of Li and O was performed using combined coincidence elastic recoil detection analysis and Rutherford backscattering spectrometry measurements in the battery with 8 MeV He ions, and the Li and O transport was measured in operando. Reversible Li transport was observed from the LMO anode to the NbO cathode on charging and vice versa during discharging. O transport was observed from the LMO anode to the NbO cathode on first charging with 3.5 V but was not observed on further charging and discharging of the battery. Our in-operando measurements allow direct and quantitative observation of Li and O transport during charge-discharge cycles for thin-film batteries.
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| 5. |
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| 6. |
- Uvo, Cintia Bertacchi, et al.
(författare)
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Statistical atmospheric downscaling for rainfall estimation in Kyushu Island, Japan
- 2001
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Ingår i: Hydrology and Earth System Sciences. - : Copernicus GmbH. - 1027-5606 .- 1607-7938. ; 5:2, s. 259-271
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Tidskriftsartikel (refereegranskat)abstract
- The present paper develops linear regression models based on singular value decomposition (SVD) with the aim of downscaling atmospheric variables statistically to estimate average rainfall in the Chikugo River Basin, Kyushu Island, southern Japan, on a 12-hour basis. Models were designed to take only significantly correlated areas into account in the downscaling procedure. By using particularly precipitable water in combination with wind speeds at 850 hPa, correlation coefficients between observed and estimated precipitation exceeding 0.8 were reached. The correlations exhibited a seasonal variation with higher values during autumn and winter than during spring and summer. The SVD analysis preceding the model development highlighted three important features of the rainfall regime in southern Japan: (1) the so-called Bai-u front which is responsible for the majority of summer rainfall. (2) the strong circulation pattern associated with autumn rainfall, and (3) the strong influence of orographic lifting creating a pronounced east-west gradient across Kyushu Island. Results confirm the feasibility of establishing meaningful statistical relationships between atmospheric state and basin rainfall even at time scales of less than one day.
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| 7. |
- Zeichner, Sarah S., et al.
(författare)
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Polycyclic aromatic hydrocarbons in samples of Ryugu formed in the interstellar medium
- 2023
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Ingår i: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 382:6677, s. 1411-1415
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Tidskriftsartikel (refereegranskat)abstract
- Polycyclic aromatic hydrocarbons (PAHs) contain less than or similar to 20% of the carbon in the interstellar medium. They are potentially produced in circumstellar environments (at temperatures greater than or similar to 1000 kelvin), by (similar to 10 kelvin) interstellar clouds, or by processing of carbon-rich dust grains. We report isotopic properties of PAHs extracted from samples of the asteroid Ryugu and the meteorite Murchison. The doubly-C-13 substituted compositions (Delta 2x(13)C values) of the PAHs naphthalene, fluoranthene, and pyrene are 9 to 51 parts per thousand higher than values expected for a stochastic distribution of isotopes. The Delta 2x(13)C values are higher than expected if the PAHs formed in a circumstellar environment, but consistent with formation in the interstellar medium. By contrast, the PAHs phenanthrene and anthracene in Ryugu samples have Delta 2x(13)C values consistent with formation by higher-temperature reactions.
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