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- Sabri, Muhammad Haziq Mohammad, et al.
(författare)
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Very High Frequency and Microwave Radiation Associated with Initial Breakdown Process in CG Lightning Flashes from Tropical Storms
- 2021
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Ingår i: 2021 35TH INTERNATIONAL CONFERENCE ON LIGHTNING PROTECTION (ICLP) AND XVI INTERNATIONAL SYMPOSIUM ON LIGHTNING PROTECTION (SIPDA). - : Institute of Electrical and Electronics Engineers (IEEE). - 9781665423465
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Konferensbidrag (refereegranskat)abstract
- We present the observation of VHF and microwave radiation pulses associated with initial breakdown process of five negative cloud-to-ground (-CG) flashes from two tropical storms. The -CG flashes were detected within and beyond reversal distances with the locations of the first return stroke were less than 10 km. Out of five flashes, only one detected with initial electric field change (IEC) process. Both VHF and microwave pulses were detected before the first classic IB pulse and the first microwave pulses were found to lead the first VHF pulses ranging between 0.03 and 23.9 mu s.
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| 3. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 6. |
- Elimian, K, et al.
(författare)
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Epidemiology, diagnostics and factors associated with mortality during a cholera epidemic in Nigeria, October 2020-October 2021: a retrospective analysis of national surveillance data
- 2022
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 12:9, s. e063703-
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Tidskriftsartikel (refereegranskat)abstract
- Nigeria reported an upsurge in cholera cases in October 2020, which then transitioned into a large, disseminated epidemic for most of 2021. This study aimed to describe the epidemiology, diagnostic performance of rapid diagnostic test (RDT) kits and the factors associated with mortality during the epidemic.DesignA retrospective analysis of national surveillance data.Setting33 of 37 states (including the Federal Capital Territory) in Nigeria.ParticipantsPersons who met cholera case definition (a person of any age with acute watery diarrhoea, with or without vomiting) between October 2020 and October 2021 within the Nigeria Centre for Disease Control surveillance data.Outcome measuresAttack rate (AR; per 100 000 persons), case fatality rate (CFR; %) and accuracy of RDT performance compared with culture using area under the receiver operating characteristic curve (AUROC). Additionally, individual factors associated with cholera deaths and hospitalisation were presented as adjusted OR with 95% CIs.ResultsOverall, 93 598 cholera cases and 3298 deaths (CFR: 3.5%) were reported across 33 of 37 states in Nigeria within the study period. The proportions of cholera cases were higher in men aged 5–14 years and women aged 25–44 years. The overall AR was 46.5 per 100 000 persons. The North-West region recorded the highest AR with 102 per 100 000. Older age, male gender, residency in the North-Central region and severe dehydration significantly increased the odds of cholera deaths. The cholera RDT had excellent diagnostic accuracy (AUROC=0.91; 95% CI 0.87 to 0.96).ConclusionsCholera remains a serious public health threat in Nigeria with a high mortality rate. Thus, we recommend making RDT kits more widely accessible for improved surveillance and prompt case management across the country.
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| 7. |
- Sabri, Muhammad Haziq Mohammad, et al.
(författare)
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A study of cloud-to-ground lightning flashes initiated by fast positive breakdown
- 2022
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Ingår i: Atmospheric research. - : Elsevier. - 0169-8095 .- 1873-2895. ; 276
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we examine the initiation event of two tropical negative cloud to ground (CG) lightning flashes within reversal distance (<8 km) detected on 12 (CG1) and 24 (CG2) November 2019, respectively. The CG flashes were recorded using a fast antenna (FA), slow antenna (SA), magnetic field (B-field), and very high frequency (VHF) sensors located at two observation stations (ST1 and ST2) 13.26 km apart. The key finding is that CG1 flash was initiated by a short VHF pulse followed by a VHF burst (fast positive breakdown) while CG2 flash was initiated by a VHF burst (fast positive breakdown) not preceded by a short VHF pulse. The VHF burst was a precursor for initiation of a narrow bipolar event (NBE)-like pulse and initial electric field changes (IECs). Based on the VHF interferometer map, the VHF sources of NBE-like pulses have been propagated upward predominantly vertical. The initiation altitude, total length of the VHF sources propagation, estimated velocity of NBE-like pulse for CG1 flash were 4.5 +/- 0.5 km, 1.9-3.8 km, and 2.4 x 108 to 4.8 x 108 ms-1, respectively, and for CG2 flash were 5.1 +/- 0.8 km, 0.2-3.0 km, and 2.7 x 107 to 4.1 x 108 ms-1, respectively. It is evident that IECs process has been initiated during fast positive streamers propagation. It can be suggested that the IECs process resulted from charge transfer during a fast positive breakdown. The durations and magnitudes of IECs for CG1 flash were 248.5 mu s and 27.97 V/m, respectively, and for CG2 flash were 265.8 mu s and 2.31 V/m, respectively.
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| 8. |
- Sabri, Muhammad Haziq Mohamad, et al.
(författare)
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Environmental Analysis of Quasi-Static Electric Field Changes of Tropical Lightning Flashes
- 2019
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Ingår i: Ekoloji. - 1300-1361. ; 28:107, s. 373-378
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Tidskriftsartikel (refereegranskat)abstract
- The environmental conditions leading to the bouncing-wave discharge and the subsequent electron beam remain to be investigated in more detailed future studies. The analysis of quasi-static initial electric field changes (IECs) were found at the beginning of all 24 lightning flashes detected within reversal distance (22 Negative Cloud-to-Ground (–CG) and 2 normal Intra-Cloud (IC) flashes) in a tropical storm on June 15th, 2017 close to our station in Malacca, Malaysia (2.314077° N, 102.318282° E). The IECs durations averaged 4.28 ms for –CG flashes (range 1.48 to 9.45 ms) and averaged 11.30 ms for normal ICs flashes (range 7.24 to 15.35 ms). In comparison to Florida storms, the duration of IECs for –CG and IC flashes were 0.18 ms (range 0.08 to 0.33 ms) and 1.53 ms (range 0.18 to 5.70 ms), respectively. Moreover, the magnitudes of E-change for tropical thunderstorm were 0.13 V/m (range 0.03 to 0.44 V/m) for –CG flashes and -0.20 V/m (range -0.13 to -0.27 V/m) for IC flashes. The E-change magnitudes of tropical flashes are significantly larger than Florida flashes.
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| 10. |
- Zainuddin, Ahmad Anwar, et al.
(författare)
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Prototyping and Early Validation of an Integrated, Electrochemical and Mass Three-sensor Array for Dengue Detection
- 2021
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Ingår i: PROCEEDINGS OF THE 15TH INTERNATIONAL JOINT CONFERENCE ON BIOMEDICAL ENGINEERING SYSTEMS AND TECHNOLOGIES (BIODEVICES), VOL 1. - : SCITEPRESS. - 9789897585524 ; , s. 204-211
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Konferensbidrag (refereegranskat)abstract
- This paper presents the current progress towards a lab-on-chip biosensor for early dengue detection, consisting of an integrated sensor with dual-function working electrode that enables in-situ measurements of both electrochemical impedance spectroscopy (EIS) and quartz crystal microbalance (QCM) enclosed in a miniaturized 3D-printed package equipped with electrical contacts and sample fluid delivery to the quartz biosensor array. The sensors consist of an array of three 10 MI-lz IEQCM biosensors on a single quartz substrate. Early validation is performed for future dengue sensing application. We report the design, optimisation, and fabrication of the sensors, as well as early optimisation and validation of surface bioconjugation of antibodies. This lab-on-chip has the potential to provide accurate dengue detection due to its high sensitivity and dynamic range, as well as providing rapid and early dengue detection in point-of-care settings.
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