SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Mukhopadhyay Pamela) "

Sökning: WFRF:(Mukhopadhyay Pamela)

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Caretta, Martina Angela, et al. (författare)
  • Water
  • 2022
  • Ingår i: Climate Change 2022: Impacts, Adaptation and Vulnerability : Contribution of Working Group II to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change - Contribution of Working Group II to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change.
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
  •  
2.
  •  
3.
  • Newell, Felicity, et al. (författare)
  • Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets
  • 2019
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited due to the paucity of comprehensive mutation data on this rare tumor type. To better understand the genomic landscape of mucosal melanoma, here we describe whole genome sequencing analysis of 67 tumors and validation of driver gene mutations by exome sequencing of 45 tumors. Tumors have a low point mutation burden and high numbers of structural variants, including recurrent structural rearrangements targeting TERT, CDK4 and MDM2. Significantly mutated genes are NRAS, BRAF, NF1, KIT, SF3B1, TP53, SPRED1, ATRX, HLA-A and CHD8. SF3B1 mutations occur more commonly in female genital and anorectal melanomas and CTNNB1 mutations implicate a role for WNT signaling defects in the genesis of some mucosal melanomas. TERT aberrations and ATRX mutations are associated with alterations in telomere length. Mutation profiles of the majority of mucosal melanomas suggest potential susceptibility to CDK4/6 and/or MEK inhibitors.
  •  
4.
  • Pettersson-Kymmer, Ulrika, et al. (författare)
  • HLA and KIR Associations of Cervical Neoplasia
  • 2018
  • Ingår i: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 218:12, s. 2006-2015
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognised by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inheritance of particular HLA-KIR combinations would increase cervical neoplasia risk.Methods: Here, we used HLA and KIR dosages imputed from SNP genotype data from 2,143 cervical neoplasia cases and 13,858 healthy controls of European decent.Results: Four novel HLA alleles were identified in association with cervical neoplasia: HLA-DRB3*9901 (OR=1.24, P=2.49×10-9), HLA-DRB5*0101 (OR=1.29, P=2.26×10-8), HLA-DRB5*9901 (OR=0.77, P=1.90×10-9) and HLA-DRB3*0301 (OR=0.63, P=4.06×10-5), due to their linkage disequilibrium with known cervical neoplasia-associated HLA-DRB1 alleles. We also found homozygosity of HLA-C1 group alleles is a protective factor for HPV16-related cervical neoplasia (C1/C1, OR=0.79, P=0.005). This protective association was restricted to carriers of either KIR2DL2 (OR=0.67, P=0.00045) or KIR2DS2 (OR=0.69, P=0.0006).Conclusions: Our findings suggest that HLA-C1 group alleles play a role in protecting against HPV16-related cervical neoplasia, mainly through a KIR-mediated mechanism.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4
Typ av publikation
tidskriftsartikel (3)
bokkapitel (1)
Typ av innehåll
refereegranskat (3)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Ohlsson, Claes, 1965 (2)
Hemminki, Kari (2)
Hildesheim, Allan (2)
Schwartz, Stephen M. (2)
Pettersson-Kymmer, U ... (2)
Brown, Matthew A. (2)
visa fler...
Rader, Janet S (2)
Wentzensen, Nicolas (2)
Hallmans, Goran (1)
Kumar, Manish (1)
Lautze, Jonathan (1)
Pearson, John V. (1)
Waddell, Nicola (1)
Wang, Sophia (1)
Hayward, Nicholas K (1)
Mann, Graham J (1)
Jönsson, Göran (1)
Eklund, Lina (1)
Wang, Xuan (1)
Adams, David J (1)
Long, Georgina V (1)
Liu, Junguo (1)
Lo, Serigne (1)
Scolyer, Richard A. (1)
Thompson, John F. (1)
Wang, Sophia S. (1)
Gelfan, Alexander (1)
Craig, M (1)
Mustonen, Tero (1)
Caretta, Martina Ang ... (1)
Garland, Suzanne M. (1)
Bastian, Boris C (1)
Fuss, Sabine (1)
Mukherji, Aditi (1)
Fanghella, Valeria (1)
Srinivasan, Jaishri (1)
Parajuli, Jagadish (1)
Priya, Ritu (1)
Seigerman, Cydney Ka ... (1)
Arfanuzzaman, Md (1)
Betts, Richard A. (1)
Hirabayashi, Yukiko (1)
Lissner, Tabea Katha ... (1)
Lopez Gunn, Elena (1)
Morgan, Ruth (1)
Mwanga, Sixbert (1)
Supratid, Seree (1)
Araos, Malcolm (1)
Balasubramanya, Soum ... (1)
Brackel, Angelica Ka ... (1)
visa färre...
Lärosäte
Lunds universitet (3)
Göteborgs universitet (2)
Umeå universitet (1)
Språk
Engelska (4)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (3)
Naturvetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy