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Sökning: WFRF:(Mussbacher M)

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  • Mussbacher, M, et al. (författare)
  • I < KAPPA > B KINASE 2 IN ATHEROSCLEROSIS
  • 2018
  • Ingår i: ATHEROSCLEROSIS. - : Elsevier BV. - 0021-9150. ; 275, s. E5-E5
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Schrottmaier, Waltraud C., et al. (författare)
  • Platelet-stored antibodies potently diminish viral infection in vitro and in vivo
  • 2019
  • Ingår i: Acta Physiologica. - : John Wiley & Sons. - 1748-1708 .- 1748-1716. ; 227:S718, s. 187-187
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Besides their primary role in haemostasis, platelets are actively involved in immune responses as they respond to various inflammatory stimuli, including microbial infection. Further, platelets contain intracellular IgG, but their physiologic function remains unknown. Thus, we aimed to elucidate the function of platelet-derived IgGs and their effect on viral infections. Human and murine platelets contained IgG which were released upon shear stress. However, IgG loss did not correlate with P-Selectin exposure or CXCL4 release and α-granule deficient (Nbeal2-/-) platelets failed to show reduced IgG content and release, indicating an extragranular IgG storage site within platelets. While platelet IgG could derive from megakaryocytes that have taken up IgG from the bone marrow microenvironment, naïve platelets also took up IgG directly from plasma in vitro and in vivo. Murine platelets from anti-IAV IgG seropositive mice reduced IAV infection in vitro and in vivo more efficiently than plasma containing comparable IgG levels. Further, human platelets from anti-CMV IgG seropositive but not seronegative donors also potently neutralized in vitro CMV-infection of HUVEC under microvascular shear stress. Our data indicate that IgG storage in platelets may not be restricted to α-granules. Further, our results show that platelets have the potential to mediate potent IgG-mediated antiviral effects both in vitro and in vivo directly at foci of infection. This indicates that platelet-derived IgG may represent a yet unexplored mechanism for focused serological immunity.
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  • Mussbacher, G., et al. (författare)
  • The Relevance of Model-Driven Engineering Thirty years from Now
  • 2014
  • Ingår i: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). - Cham : Springer International Publishing. - 1611-3349 .- 0302-9743. ; 8767, s. 183-200
  • Tidskriftsartikel (refereegranskat)abstract
    • Although model-driven engineering (MDE) is now an established approach for developing complex software systems, it has not been universally adopted by the software industry. In order to better understand the reasons for this, as well as to identify future opportunities for MDE, we carried out a week-long design thinking experiment with 15 MDE experts. Participants were facilitated to identify the biggest problems with current MDE technologies, to identify grand challenges for society in the near future, and to identify ways that MDE could help to address these challenges. The outcome is a reflection of the current strengths of MDE, an outlook of the most pressing challenges for society at large over the next three decades, and an analysis of key future MDE research opportunities.
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  • Resultat 1-10 av 13

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