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- Cannata, Stefano, et al.
(författare)
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One-year outcomes after transcatheter aortic valve implantation with the latest-generation SAPIEN balloonexpandable valve : the S3U registry
- 2023
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Ingår i: EuroIntervention. - : Europa Digital & Publishing. - 1774-024X .- 1969-6213. ; 18:17, s. 1418-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Initial data about the performance of the new-generation SAPIEN 3 Ultra (S3U) valve are highly promising. However, evidence about the longer-term performance and safety of the S3U is scarce.Aims: We aimed to investigate the 1-year clinical and echocardiographic outcomes of transcatheter aortic valve implantation (TAVI) using the S3U compared with its predecessor, the SAPIEN 3 valve (S3).Methods: The SAPIEN 3 Ultra registry included consecutive patients who underwent transfemoral TAVI at 12 European centres with the S3U or S3 between October 2016 and December 2020. One-to-one propensity score (PS) matching was performed to account for differences in baseline characteristics. The primary outcomes of interest were all-cause death and the composite of all-cause death, disabling stroke and hospitalisation for heart failure at 1 year.Results: The overall study cohort encompassed 1,692 patients treated with either the S3U (n=519) or S3 (n=1,173). The PS-matched population had a total of 992 patients (496 per group). At 1 year, the rate of death from any cause was 4.9% in the S3U group and 6.3% in the S3 group (p=0.743). Similarly, there were no significant differences in the rates of the primary composite outcome (9.5% in the S3 group and 6.6% in the S3U group; p=0.162). The S3U was associated with lower rates of mild paravalvular leak (PVL) compared with the S3 (odds ratio 0.63, 95% confidence interval: 0.44 to 0.88; p<0.01). No significant differences in transprosthetic gradients were observed between the two groups.Conclusions: Compared with the S3, the S3U transcatheter heart valve was associated with similar 1-year clinical outcomes but reduced rates of mild PVL.
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| 2. |
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| 3. |
- Strüber, Martin, et al.
(författare)
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HeartMate II left ventricular assist device, early European experience
- 2008
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Ingår i: European Journal of Cardio-Thoracic Surgery. - : Oxford University Press (OUP). - 1010-7940 .- 1873-734X. ; 34:2, s. 289-294
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The novel axial flow left ventricular assist device HeartMate II was introduced into clinical practice in Europe as part of the pilot study and after CE approval in November 2005. In order to get an overview of the use and performance of the device in Europe a group of investigators was founded to compare the initial results. Methods: In a retrospective analysis of the first 101 consecutive cases in Europe, data were collected with regard to postoperative outcome and severe adverse events and anticoagulation protocols. Results were stratified by intention to treat as a bridge to transplant or as chronic support therapy in heart failure (destination therapy). Results: In 70% of patients, the HeartMate II was intended as a bridge to transplant therapy, in 30%, it was used as a destination therapy device. The perioperative mortality post implant was 20% in the bridge to transplant patients and 7% in the destination therapy arm. However, after 1 year a comparable survival was observed in both groups (69% destination therapy, 63% bridge to transplant). Main causes of death were multiple organ failure (n = 12) and cerebrovascular accidents (n = 5). All, but one cerebrovascular accident occurred in the first 9 days after surgery. Only one other death was reported thereafter and there was no mechanical failure of the device. Conclusions: Even in the early experience the HeartMate II was used as a chronic support device in a substantial number of patients in Europe. Although the total experience is still limited, the incidence of cerebrovascular accidents is very low and the survival beyond the perioperative period is excellent. © 2008 European Association for Cardio-Thoracic Surgery.
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| 4. |
- Tornatore, Massimo, et al.
(författare)
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A Survey on Network Resiliency Methodologies against Weather-based Disruptions
- 2016
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Ingår i: PROCEEDINGS OF 2016 8TH INTERNATIONAL WORKSHOP ON RESILIENT NETWORKS DESIGN AND MODELING (RNDM). - : IEEE. - 9781467390231 ; , s. 23-34
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Konferensbidrag (refereegranskat)abstract
- Due to the increasing dependence on network services of our society, research has recently been concentrating on enhancing traditional protection strategies to withstand large-scale failures, as in case of disaster events. The recently-formed EU-funded RECODIS project aims at coordinating and fostering research collaboration in Europe on disaster resiliency in communication networks. In particular, the Working Group (WG) 2 of the RECODIS project focuses on developing new network resiliency strategies to survive weather-based disruptions. As a first step, WG2 members have conducted a comprehensive literature survey on existing studies on this topic. This paper classifies and summarizes the most relevant studies collected by WG2 members in this first phase of the project. While the majority of studies regarding weather-based disruptions deals with wireless network (as wireless channel is directly affected by weather conditions), in this survey we cover also disaster resiliency approaches designed for wired network if they leverage network reconfiguration based on disaster "alerts", considering that many weather-based disruptions grant an "alert" thanks to weather forecast.
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| 5. |
- Ye, Yabin, et al.
(författare)
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Energy-Efficient Resilient Optical Networks : Challenges and Trade-offs
- 2015
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Ingår i: IEEE Communications Magazine. - 0163-6804 .- 1558-1896. ; 53:2, s. 144-150
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Tidskriftsartikel (refereegranskat)abstract
- Energy efficiency and resilience are two well established research topics in optical transport networks. However, their overall objectives (i.e., power minimization and resource utilization/availability maximization) conflict. In fact, provisioning schemes optimized for best resilience performance are in most cases not energy-efficient in their operations, and vice versa. However, very few works in the literature consider the interesting issues that may arise when energy efficiency and resilience are combined in the same networking solution. The objective of this article is to identify a number of research challenges and trade-offs for the design of energy-efficient and resilient optical transport networks from the perspective of long-term traffic forecasts, short-term traffic dynamics, and service level agreement requirements. We support the challenges with justifying numbers based on lessons learned from our previous work. The article also discusses suitable metrics for energy efficiency and resilience evaluation, in addition to a number of steps that need to be taken at the standardization level to incorporate energy efficiency into already existing and well established protocols.
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