| 1. |
- Sawcer, Stephen, et al.
(författare)
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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- 2011
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 476:7359, s. 214-219
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Tidskriftsartikel (refereegranskat)abstract
- Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis.
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| 2. |
- Beecham, Ashley H, et al.
(författare)
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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
- 2013
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:11, s. 1353-60
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Tidskriftsartikel (refereegranskat)abstract
- Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
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| 3. |
- Magalhaes, Sandra, et al.
(författare)
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The EnvIMS Study: Design and Methodology of an International Case-Control Study of Environmental Risk Factors in Multiple Sclerosis
- 2015
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Ingår i: Neuroepidemiology. - : Karger. - 0251-5350 .- 1423-0208. ; 44:3, s. 173-181
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Tidskriftsartikel (refereegranskat)abstract
- Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system, often resulting in significant neurological disability. The causes of MS are not known; however, the incidence of MS is increasing, thereby suggesting that changes in lifestyle and/or environmental factors may be responsible. On this background, the Environmental Risk Factors in MS Study or EnvIMS study was designed to further explore the etiology of MS. The design and methodology are described, providing details to enable investigators to (i) use our experiences to design their own studies; (ii) take advantage of, and build on the methodological work completed for, the EnvIMS study; (iii) become aware of this data source that is available for use by the research community. Methods: EnvIMS is a multinational case-control study, enrolling 2,800 cases with MS and 5,012 population-based controls in Canada, Italy, Norway, Serbia and Sweden. The study was designed to investigate the most commonly implicated risk factors for MS etiology using a self-report questionnaire. Results/Conclusions:The use of a common methodology to study MS etiology across several countries enhances the comparability of results in different geographic regions and research settings, reduces the resources required for study design and enhances the opportunity for data harmonization.
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| 4. |
- Myhr, David
(författare)
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Aktivitet: ABBA the Music
- 2011
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Annan publikation (populärvet., debatt m.m.)abstract
- David Myhr playing the role of "Benny" from ABBA in a singback performance in the TV-show "Miss Belgium".
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| 8. |
- Myhr, David, 1970-
(musiker, creator_code:cre_t)
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And Now This
- 2021
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Konstnärligt arbete (refereegranskat)abstract
- Swedish songwriter extraordinaire David Myhr announces new EP with lead single We Wanted To Shine. The new 4-tracker, due 21st May, is titled And Now This and resumes the fruitful collaboration from Myhr's 2018 Lucky Day album made with Nashville-based producer/musician Brad Jones (Josh Rouse, Matthew Sweet, Jill Sobule, Marshall Crenshaw) and fellow Swede Andreas Quincy Dahlbäck. Where Lucky Day perhaps demonstrated a more mature singer/songwriter sound, And Now This returns to his crowd-pleaser hybrid pop/rock roots that saw Myhr’s 90s band The Merrymakers make global waves, especially in Japan. With a day-gig as songwriting teacher (Luleå University of Technology, The Royal College of Music in Stockholm,) We Wanted To Shine saw Myhr take some of his own songwriting advice: "As a songwriter you're often looking for a starting point, an idea to spark off. One method I recommend to students is to simply start with a title." "I had a Tom Petty book on the coffee table in front of me so I opened a page at random and my eyes landed on the words ‘we really wanted to shine’. It was a quote about The Heartbreakers performance at the tribute to George Harrison in The Royal Albert Hall, on the anniversary of his death." From there, the creative juices flowed. "All I had to do was to start singing! The chorus came right away. A verse melody followed quickly and Brad Jones then further developed the lyrics”."The song could be interpreted as being about a struggling musician that craves attention and recognition, which of course is something that I can relate to! But it is also about wanting to succeed and - perhaps a bit amateur psychology - some kind of deep-seated need for validation from your parents." There’s been talk for years now about the album format being dead. It may or may not be true but David said: "Brad Jones encouraged me to start working in the EP format. I must say I like it. This may be the first in a trilogy. If this is the powerpop EP, maybe the next one will be the acoustic EP. And the third… the Drum&Bass EP!!? We'll see!"The single We Wanted To Shine is released 7th May and the EP And Now This out 21st May on British indie label Lojinx.
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| 9. |
- Myhr, David
(musiker, creator_code:cre_t)
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Arrival : The music of ABBA
- 2011
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Konstnärligt arbeteabstract
- David Myhr playing the role of "Benny Andersson" (keyboards/vocals) with internationally succesful ABBA tribute-band Arrival.
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| 10. |
- Myhr, David
(musiker, creator_code:cre_t)
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Beyond Belief : A tribute to Elvis Costello ("Veronica")
- 2015
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Konstnärligt arbete (ljud/tal)abstract
- David Myhr's own inimitable take on Elvis Costello’s 1989 classic “Veronica” is track #6 on the American compilation “Beyond Belief: A tribute to Elvis Costello“. Other contributors included Matthew Sweet, The Rubinoos and Mike Viola. The highly recommended compilation is out on Spyder Records and the proceedings goes to charity. The compilation is co-produced by producer, musician, author and reviewer John Borack and Olivia Frain who invited a series of groups and artists from all over the world (of the power pop genre) from whom they selected the 50 that finally made it on to the album. They later found a partner in record label Spyder Pop Records who took care of the release. 100% of the proceeds from the Spyderpop release will go to the Mr. Holland's Opus Foundation (founded by the late composer Michael Kamen) and help put musical instruments into the hands of children in underserved areas. This fundraising album is going towards a great cause and deserves to be in your personal music collection.“Veronica” was co-written with Paul McCartney and Myhr declares it his favourite Costello song in no small part influenced by his life-long obsession with The Beatles.Though “Veronica” was Costello’s most successful song in the US it has so far been covered by very few artists (this may be the first time that a cover version finds its way out onto Spotify).“Veronica”(Elvis Costello / Paul McCartney)David Myhr – lead and background vocals, acoustic and electric guitars, harpsichord, glockenspielAndreas Dahlbäck – drums, tambourineRikard Lidhamn – bassMarcus Olsson – piano, organAnders Pettersson – electric guitarElin Andersson – trumpetProduced by David MyhrEngineered by Raoul Hamilton, Petter Näse, and David Myhr. Mixed by Marcus Black at Jelly Road.Recorded at Durango Recording, Stockholm, and Strong Melody Studio, Stockholm.
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