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Numrering	Referens	Omslagsbild	Hitta
1.	LUNDGREN, JD, et al. (författare) Factors associated with the development of Pneumocystis carinii pneumonia in 5,025 European patients with AIDS. AIDS in Europe Study Group 1995 Ingår i: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - : Oxford University Press (OUP). - 1058-4838. ; 21:1, s. 106-113 Tidskriftsartikel (refereegranskat)
2.	Pedersen, C, et al. (författare) Epidemiology of cryptosporidiosis among European AIDS patients 1996 Ingår i: Genitourinary medicine. - : BMJ. - 0266-4348. ; 72:2, s. 128-131 Tidskriftsartikel (refereegranskat)
3.	Sanfilippo, C., et al. (författare) The chitinases expression is related to Simian Immunodeficiency Virus Encephalitis (SIVE) and in HIV encephalitis (HIVE) 2017 Ingår i: Virus Research. - : Elsevier BV. - 0168-1702. ; 227, s. 220-230 Tidskriftsartikel (refereegranskat)abstract Objectives Human Immunodeficiency Virus (HIV) infection can induce neurocognitive complications classified as HIV-associated neurocognitive disorder (HAND). The chitinase family is associated with innate immunity cells and many infectious diseases. Methods We analyzed microarray datasets obtained from NCBI in order to verify the expression of chitinase family genes in hippocampus of uninfected rhesus macaques versus those with histopathologic evidence of Simian Immunodeficiency Virus Encephalitis (SIVE). Moreover, we have analysed two human microarray datasets to verify the results obtained in macaques hippocampus affected by SIVE. For these studies, we have also used the open source tools Genome-scale Integrated Analysis of gene Networks in Tissues (GIANT) to identify the chitinase genes network. Results CHIT1, CHI3L1 and CHI3L2 levels were significantly increased in SIVE hippocampus as compared to non-infected control specimens. Furthermore, we found a negative correlation between CHIA vs. Brain Viral Load (BVL). These data was confirmed partially in human brain section of HAD/HIVE subjects. Also, we showed that HIV-1 was able to modulate the expression of CHIT1, CHI3L1, CHI3L2 and CHID1 in human macrophages. Conclusions These results suggest that chitinase gene expression is altered in SIVE and in HAD/HIVE brain sections and call for more studies examining whether this is a protective immunological reaction or a destructive tissue response to encephalitis. © 2016 Elsevier B.V.

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Författare/redaktör: Ferlini, A. (2); Bentwich, Z (2); Phillips, A. (2); Clotet, B (2); Clumeck, N (2); Gatell, J (2); visa fler...; Antunes, F (2); Danner, S (2); Hirschel, B (2); Katlama, C (2); Pinching, A (2); Vella, S (2); Barton, S (2); Mulcahy, F (2); Olsson, C (2); PEDERSEN, C (2); LUNDGREN, JD (2); GERSTOFT, J (2); Pehrson, P (2); Nielsen, T. (2); Melbye, M (2); Yust, I (2); Lazzarin, A (2); Hemmer, R (2); Miro, J (2); Johnson, A (2); Giannelli, F. (2); Ranki, A. (2); Skinhoj, P. (2); Ledergerber, B (2); Jensen, G (2); Goebel, FD (2); Dietrich, M. (2); Papadopoulos, A (2); Maayan, S (2); Gjorup, I (2); Glauser, M. (2); Nielsen, JO (2); BARTON, SE (2); KOSMIDIS, J (2); DEWIT, S (2); SOMMEREIJNS, B (2); BENTSEN, K (2); VALLE, SL (2); BERLUREAU, P (2); SCHWANDER, S (2); BANHEGYI, D (2); BENISHAI, Z (2); SACKS, T (2); CHIESI, A (2); visa färre...

Lärosäte: Karolinska Institutet (2); Göteborgs universitet (1)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

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