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- Ghia, P., et al.
(författare)
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Early stages in the ontogeny of small B-cell lymphomas : genetics and microenvironment
- 2017
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 282:5, s. 395-414
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Tidskriftsartikel (refereegranskat)abstract
- In this review, we focus on the mechanisms underlying lymphomagenesis in chronic lymphocytic leukaemia, follicular lymphoma, mantle cell lymphoma and splenic marginal zone lymphoma. The cells of origin of these small B-cell lymphomas are distinct, as are the characteristic chromosomal lesions and clinical courses. One shared feature is retention of expression of surface immunoglobulin. Analysis of this critical receptor reveals the point of differentiation reached by the cell of origin. Additionally, the sequence patterns of the immunoglobulin-variable domains can indicate a role for stimulants of the B-cell receptor before, during and after malignant transformation. The pathways driven via the B-cell receptor are now being targeted by specific kinase inhibitors with exciting clinical effects. To consider routes to pathogenesis, potentially offering earlier intervention, or to identify causative factors, genetic tools are being used to track pretransformation events and the early phases in lymphomagenesis. These methods are revealing that chromosomal changes are only one of the many steps involved, and that the influence of surrounding cells, probably multiple and variable according to tissue location, is required, both to establish tumours and to maintain growth and survival. Similarly, the influence of the tumour microenvironment may protect malignant cells from eradication by treatment, and the resulting minimal residual disease will eventually give rise to relapse. The common and different features of the four lymphomas will be summarized to show how normal B lymphocytes can be subverted to generate tumours, how these tumours evolve and how their weaknesses can be attacked by targeted therapies.
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- Alfs, D., et al.
(författare)
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Drift chamber calibration and particle identification in the P-349 experiment
- 2019
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Ingår i: MESON 2018 - 15th International Workshop on Meson Physics. - : EDP Sciences.
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Konferensbidrag (refereegranskat)abstract
- The goal of the P-349 experiment is to test whether 3.5 GeV/c antiprotons produced in high-energy proton-proton collisions are polarized in view of the preparation of a polarized antiproton beam. In this article, we present the details of the ongoing analysis focused on the drift chambers calibration and particle identification with DIRC.
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| 5. |
- Alfs, D., et al.
(författare)
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Drift Chamber Calibration And Track Reconstruction In The P349 Antiproton Polarization Experiment
- 2017
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Ingår i: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 48:10, s. 1983-1988
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Tidskriftsartikel (refereegranskat)abstract
- The goal of the P349 experiment is to test whether the antiproton production process can be itself a source of antiproton polarization. In this article, we present the motivation and details of the performed measurement. We report on the status of the analysis focusing mainly on calibration of the drift chambers and 3d track reconstruction.
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| 6. |
- Alfs, D., et al.
(författare)
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Status of the analysis for the search of polarization in the antiproton production process
- 2016
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Ingår i: MESON 2016 - 14th International Workshop On Meson Production, Properties And Interaction. - : EDP Sciences.
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Konferensbidrag (refereegranskat)abstract
- The P-349 experiment aims to test whether for antiprotons the production process itself can be a source of polarization in view of the preparation of a polarized antiproton beam. In this article we present the details of performed measurements and report on the status of the ongoing analysis.
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| 8. |
- Dangtip, S, et al.
(författare)
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A facility for measurements of nuclear cross sections for fast neutron cancer therapy
- 2000
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 452:3, s. 484-504
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Tidskriftsartikel (refereegranskat)abstract
- A facility for measurements of neutron-induced double-differential light-ion production cross-sections, for application within. e.g.. fast neutron cancer therapy, is described. The central detection elements are three-detector telescopes consisting of two
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