| 1. |
- Goldsmith, Paul F., et al.
(författare)
-
Herschel Measurements of Molecular Oxygen in Orion
- 2011
-
Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 737:2, s. 96 (1-17)
-
Tidskriftsartikel (refereegranskat)abstract
- We report observations of three rotational transitions of molecular oxygen (O2) in emission from the H2 Peak 1 position of vibrationally excited molecular hydrogen in Orion. We observed the 487 GHz, 774 GHz, and 1121 GHz lines using the Heterodyne Instrument for the Far Infrared on the Herschel Space Observatory, having velocities of 11 km s–1 to 12 km s–1 and widths of 3 km s–1. The beam-averaged column density is N(O2) = 6.5 × 1016 cm–2, and assuming that the source has an equal beam-filling factor for all transitions (beam widths 44, 28, and 19''), the relative line intensities imply a kinetic temperature between 65 K and 120 K. The fractional abundance of O2 relative to H2 is (0.3-7.3) × 10–6. The unusual velocity suggests an association with a ~5'' diameter source, denoted Peak A, the Western Clump, or MF4. The mass of this source is ~10 Msun and the dust temperature is ≥150 K. Our preferred explanation of the enhanced O2 abundance is that dust grains in this region are sufficiently warm (T ≥ 100 K) to desorb water ice and thus keep a significant fraction of elemental oxygen in the gas phase, with a significant fraction as O2. For this small source, the line ratios require a temperature ≥180 K. The inferred O2 column density sime5 × 1018 cm–2 can be produced in Peak A, having N(H2) sime 4 × 1024 cm–2. An alternative mechanism is a low-velocity (10-15 km s–1) C-shock, which can produce N(O2) up to 1017 cm–2.
|
|
| 2. |
- Gulyas, Katalin, et al.
(författare)
-
Effects of 1-year anti-TNF-α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis
- 2020
-
Ingår i: Clinical Rheumatology. - : Springer Science and Business Media LLC. - 0770-3198 .- 1434-9949. ; 39:1, s. 167-175
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectivesRheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with generalized and localized bone loss. We conducted a comprehensive study using imaging (dual-energy X-ray absorptiometry, DXA) and laboratory biomarkers in order to determine bone health and to study the effects of anti-tumor necrosis factor (TNF) biologics in RA and AS.Patients and methodsThirty-six RA and 17 AS patients undergoing 1-year etanercept (ETN) or certolizumab-pegol (CZP) therapy were studied. Bone density was assessed by DXA at baseline and after 12 months. Serum C-reactive protein (CRP), calcium, phosphate, parathyroid hormone (PTH), vitamin D3, osteocalcin, procollagen type I N-propeptide (P1NP), C-terminal telopeptide (βCTX), osteoprotegerin, sclerostin (SOST), Dickkopf-1 (DKK-1), soluble receptor activator nuclear kappa B ligand (sRANKL), and cathepsin K (cathK) levels were determined at baseline and after 6 and 12 months.ResultsTNF-α inhibition was clinically effective. Anti-TNF-α halted further bone loss over 1 year. In general, anti-TNF therapy significantly increased P1NP, SOST levels, and the P1NP/βCTX ratios, while decreased DKK-1 and CathK production at different time points in most patient subsets. In the full cohort and in RA, baseline and/or 12-month bone mineral density (BMD) at multiple sites exerted inverse relationships with CRP and βCTX, and positive correlation with SOST. In AS, L2-4 BMD after 1-year biologic therapy inversely correlated with baseline βCTX, while femoral neck BMD rather showed inverse correlations with CRP.ConclusionsAnti-TNF therapy slowed down generalized bone loss, in association with clinical improvements, in both diseases. TNF blockade may enhance bone formation and suppress joint destruction. Anti-TNF therapy may act inversely on DKK-1 and SOST. Independent predictors of BMD were SOST and βCTX in RA, whilst CRP in AS.
|
|
| 3. |
- Kalmár, Péter János, et al.
(författare)
-
A MECHANIKUS THROMBECTOMIÁT MEGELÔZÔ INTRAVÉNÁS THROMBOLYSIS SZEREPE AZ AKUT AGYI NAGYÉRELZÁRÓDÁSOK KEZELÉSÉBEN : [The role of intravenous thrombolysis before mechanical thrombectomy in the treatment of large vessel occlusion strokes]
- 2022
-
Ingår i: Ideggyógyászati szemle. - : Literatura Medica Kiado. - 0019-1442 .- 2498-6208. ; 75:1-2, s. 23-29
-
Tidskriftsartikel (refereegranskat)abstract
- Background and purpose: The efficacy of intravenous thrombolysis (IVT) is moderate in the proximal vascular segments of intracranial arteries, as opposed to mecha-nical thrombectomy (MT). In the management of acute ischemic stroke (AIS) caused by large vessel occlusions (LVO), IVT prior to MT is highly recommended based on the latest guidelines, but the necessity of IVT has been questioned by the latest studies of the past years. The aim of our study was to investigate and compare the efficacy and safety of direct mechanical thrombectomy (dMT) and combined therapy (CT) for patients who suffered an AIS with LVO and were treated in our department.Methods: We investigated patients with AIS caused by LVO who were admitted up to 4.5 hours after symptom onset and underwent MT in our department between November 2017 and August 2019. Patients' data were collected in our stroke register. Patients enrolled in our study were divided into two groups depending on whether dMT or CT was used. Our primary outcome was the 30- and 90- day functional outcome measured by modified Rankin Scale (mRS). Mortality at 30- and 90- day, successful recanalization rates, and symptomatic intracranial hemorrhage were considered as secondary outcomes.Results: A total of 142 patients (age: 68.3 ± 12.6 years, 53.5% female) were enrolled in our study, including 81 (57.0%) dMT cases, and 61 (43.0%) patients who received CT. The vascular risk factors and comorbidities were significantly higher in the dMT-treated group. At day 30, the rate of favorable functional outcomes was 34.7% in dMT vs. 43.6% among those who received CT (p = 0.307), by day 90 this ratio changed to 40.8% vs. 46.3% (p = 0.542). Mortality rates at day 30 were 22.2% and 23.6% (p = 0.851), and at day 90 33.8% and 25.9% (p = 0.343). The rate of effective recanalization was 94.2% for dMT-treated patients and 98.0% for CT-treated patients (p = 0.318). Symptomatic intracranial hemorrhage was detected in 2.5% of dMT-treated patients and 3.4% of CT-treated group (p = 0.757).Conclusion: Our results suggest that CT is associated with a moderately better outcome compared to dMT. IVT prior to MT did not increase the risk of symptomatic intracranial hemorrhages.
|
|
| 4. |
- Kalmar, Peter Janos, et al.
(författare)
-
Comparing endovascular treatment methods in acute ischemic stroke Due to tandem occlusion focusing on clinical aspects
- 2021
-
Ingår i: Life. - : MDPI. - 2075-1729. ; 11:5
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Acute ischemic strokes (AIS) due to tandem occlusion (TO) of intracranial anterior large vessel and concomitant extracranial internal carotid artery (EICA) are represent in 15-20% of all ischemic strokes. The endovascular treatment (EVT) strategy for those patients is still unclear. Although the intracranial mechanical thrombectomy (MT) is considered as a standard treatment approach, the EICA lesion stent necessity remains a matter of debate. We sought to assess the efficacy and safety of EVT in tandem lesions, particularly the EICA stenting management.Methods: We retrospectively analyzed all patients with anterior circulation stroke associated with EICA lesion and receiving EVT in the three participated stroke centers between November 2017 and December 2020. Patients' data were collected from our prospective stroke registry (STAY ALIVE). Patients enrolled in our study were divided into two groups depending on whether acute carotid stenting (ACS) or balloon angioplasty only (BAO) technique was used. Our primary outcome was the 90-day functional outcome assessed by modified Rankin scale (mRS). Mortality at 90 days and symptomatic intracranial hemorrhage (sICH) were considered as secondary outcomes.Results: A total of 101 patients (age: 67 ± 10 years, 38.6% female) were enrolled in our study, including 29 (28.3%) BAO cases, and 72 (71.3%) patients treated with ACS. Patients in the BAO group were slightly older (70 ± 9 years vs. 66 ± 10 years, p = 0.054), and had higher prevalence of comorbidities such as hypertension (100.0% vs. 59.4%, p < 0.001). There was no significant difference in favorable outcomes (51.7% vs. 54.4%, p = 0.808) between the groups. However, we observed a trend towards higher rates of sICH (8.3% vs. 3.4%, p = 0.382) and 90-day mortality (23.5% vs. 13.8%, p = 0.278) with significantly higher frequency of distal embolization (39.1% vs. 17.9%, p = 0.043) in patients with ACS. In the overall population age (p = 0.013), atrial fibrillation (AF) (p = 0.008), National Institutes of Health Stroke Scale (NIHSS) baseline (p = 0.029), and successful recanalization (p = 0.023) were associated with favorable outcome.Conclusion: Endovascular approach of EICA in addition to MT was safe and effective in tandem occlusion of anterior circulation. Furthermore, our results suggest that balloon angioplasty technique without acute stenting shows a comparable favorable outcome rate to ACS with moderately less hemorrhagic events and mortality rates.
|
|
| 5. |
- Neufeld, David A., et al.
(författare)
-
HERSCHEL OBSERVATIONS OF INTERSTELLAR CHLORONIUM
- 2012
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 748:1, s. 37-
-
Tidskriftsartikel (refereegranskat)abstract
- Using the Herschel Space Observatory's Heterodyne Instrument for the Far-Infrared, we have observed parachloronium (H2Cl+) toward six sources in the Galaxy. We detected interstellar chloronium absorption in foreground molecular clouds along the sight lines to the bright submillimeter continuum sources Sgr A (+50 km s(-1) cloud) and W31C. Both the para-(H2Cl+)-Cl-35 and para-(H2Cl+)-Cl-37 isotopologues were detected, through observations of their 1(11)-0(00) transitions at rest frequencies of 485.42 and 484.23 GHz, respectively. For an assumed ortho-to-para ratio (OPR) of 3, the observed optical depths imply that chloronium accounts for similar to 4%-12% of chlorine nuclei in the gas phase. We detected interstellar chloronium emission from two sources in the Orion Molecular Cloud 1: the Orion Bar photodissociation region and the Orion South condensation. For an assumed OPR of 3 for chloronium, the observed emission line fluxes imply total beam-averaged column densities of similar to 2 x 10(13) cm(-2) and similar to 1.2 x 10(13) cm(-2), respectively, for chloronium in these two sources. We obtained upper limits on the para-(H2Cl+)-Cl-35 line strengths toward H-2 Peak 1 in the Orion Molecular cloud and toward the massive young star AFGL 2591. The chloronium abundances inferred in this study are typically at least a factor similar to 10 larger than the predictions of steady-state theoretical models for the chemistry of interstellar molecules containing chlorine. Several explanations for this discrepancy were investigated, but none has proven satisfactory, and thus the large observed abundances of chloronium remain puzzling.
|
|
| 6. |
- Thielmann, Isabel, et al.
(författare)
-
The HEXACO-100 Across 16 Languages : A Large-Scale Test of Measurement Invariance
- 2020
-
Ingår i: Journal of Personality Assessment. - : Informa UK Limited. - 0022-3891 .- 1532-7752. ; 102:5, s. 714-726
-
Tidskriftsartikel (refereegranskat)abstract
- The HEXACO Personality Inventory-Revised (HEXACO-PI-R) has become one of the most heavily applied measurement tools for the assessment of basic personality traits. Correspondingly, the inventory has been translated to many languages for use in cross-cultural research. However, formal tests examining whether the different language versions of the HEXACO-PI-R provide equivalent measures of the 6 personality dimensions are missing. We provide a large-scale test of measurement invariance of the 100-item version of the HEXACO-PI-R across 16 languages spoken in European and Asian countries (N = 30,484). Multigroup exploratory structural equation modeling and confirmatory factor analyses revealed consistent support for configural and metric invariance, thus implying that the factor structure of the HEXACO dimensions as well as the meaning of the latent HEXACO factors is comparable across languages. However, analyses did not show overall support for scalar invariance; that is, equivalence of facet intercepts. A complementary alignment analysis supported this pattern, but also revealed substantial heterogeneity in the level of (non)invariance across facets and factors. Overall, results imply that the HEXACO-PI-R provides largely comparable measurement of the HEXACO dimensions, although the lack of scalar invariance highlights the necessity for future research clarifying the interpretation of mean-level trait differences across countries.
|
|
| 7. |
- van der Tak, F. F. S., et al.
(författare)
-
Spatially extended OH+ emission from the Orion Bar and Ridge
- 2013
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 560, s. A95 (pp. 1-10)
-
Tidskriftsartikel (refereegranskat)abstract
- Context. The reactive HnO+ ions (OH+, H2O+ and H3O+) are widespread in the interstellar medium and act as precursors to the H2O molecule. While HnO+ absorption is seen on many Galactic lines of sight, active galactic nuclei often show the lines in emission. Aims: This paper shows the first example of a Galactic source of HnO+ line emission: the Orion Bar, a bright nearby photon-dominated region (PDR). Methods: We present line profiles and maps of OH+ line emission toward the Orion Bar, and upper limits to H2O+ and H3O+ lines. We analyze these HIFI data with non-local thermodynamic equilibrium radiative transfer and PDR chemical models, using newly calculated inelastic collision data for the e-OH+ system. Results: Line emission is detected over ~1' (0.12 pc), tracing the Bar itself as well as a perpendicular feature identified as the southern tip of the Orion Ridge, which borders the Orion Nebula on its western side. The line width of ≈ 4 km s-1 suggests an origin of the OH+ emission close to the PDR surface, at a depth of AV ~ 0.3-0.5 into the cloud where most hydrogen is in atomic form. Steady-state collisional and radiative excitation models for OH+ require unrealistically high column densities to match the observed line intensity, indicating that the formation of OH+ in the Bar is rapid enough to influence its excitation. Our best-fit OH+ column density of ~ 1.0 × 1014 cm-2 is similar to that in previous absorption line studies, while our limits on the ratios of OH+/H2O+ (≳ 40) and OH+/H3O+ (≳ 15) are somewhat higher than seen before. Conclusions: The column density of OH+ is consistent with estimates from a thermo-chemical model for parameters applicable to the Orion Bar, given the current uncertainties in the local gas pressure and the spectral shape of the ionizing radiation field. The unusually high OH+/H2O+ and OH+/H3O+ ratios are probably due to the high UV radiation field and electron density in this object. In the Bar, photodissociation and electron recombination are more effective destroyers of OH+ than the reaction with H2, which limits the production of H2O+. The appearance of the OH+ lines in emission is the result of the high density of electrons and H atoms in the Orion Bar, since for these species, inelastic collisions with OH+ are faster than reactive ones. In addition, chemical pumping, far-infrared pumping by local dust, and near-UV pumping by Trapezium starlight contribute to the OH+ excitation. Similar conditions may apply to extragalactic nuclei where HnO+ lines are seen in emission.
|
|
