| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Raghavan, P., et al.
(författare)
-
Electrochemical characterization of poly(vinylidene fluoride-co-hexafluoro propylene) based electrospun gel polymer electrolytes incorporating moth temperature ionic liquids as green electrolytes for lithium batteries
- 2014
-
Ingår i: Solid State Ionics. - : Elsevier BV. - 0167-2738. ; 262, s. 77-82
-
Tidskriftsartikel (refereegranskat)abstract
- A series of gel polymer electrolytes (GPEs) based on electrospun membranes of poly(vinylidene fluoride-co-hexafluoropropylene) [P(VdF-co-HFP)] incorporating room temperature ionic liquids (RTILs), 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide complexed with lithium bis(trifluoromethylsulfonyl) inside (LiTFSI) as electrolytes have been prepared and their fundamental electrochemical properties were investigated. The morphology of electrospun membranes was examined by a field emission scanning electron microscope (FE-SEM). The membranes show uniform morphology with an average fiber diameter of 780 nm, high porosity and high electrolyte uptake. GPEs were prepared by soaking the electrospun membranes in 1 M LiTFSI in RTILs for 1 h and exhibit a high ionic conductivity of 2.4 x 10(-3)-4.5 x 10(-3) S cm(-1) at 25 degrees C. A Li/GPEs/LiFePO4 cell using these RTILs delivers high discharge capacity (similar to 140 mAh g(-1)) when evaluated at 25 degrees C at 0.1 C-rate and exhibits a very stable discharge capacity under continuous cycling. Among the GPEs, EMITFSI shows the highest electrochemical properties although the solid electrolyte interface (SEI) layer was not formed.
|
|
| 6. |
- Carmona-Gutierrez, D, et al.
(författare)
-
The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species
- 2019
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 651-
-
Tidskriftsartikel (refereegranskat)abstract
- Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′-dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescence of human cell cultures, and protects mice from prolonged myocardial ischaemia. Concomitantly, DMC induces autophagy, which is essential for its cytoprotective effects from yeast to mice. This pro-autophagic response induces a conserved systemic change in metabolism, operates independently of TORC1 signalling and depends on specific GATA transcription factors. Notably, we identify DMC in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine. In summary, we have identified and mechanistically characterised the conserved longevity-promoting effects of a natural anti-ageing drug.
|
|
| 7. |
|
|
| 8. |
- Motiño, O, et al.
(författare)
-
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
- 2022
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:41, s. e2207344119-
-
Tidskriftsartikel (refereegranskat)abstract
- Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a monoclonal antibody neutralizing ACBP/DBI (α-DBI) protects the murine liver against ischemia/reperfusion damage, intoxication by acetaminophen and concanavalin A, and nonalcoholic steatohepatitis caused by methionine/choline-deficient diet as well as against liver fibrosis induced by bile duct ligation or carbon tetrachloride. α-DBI downregulated proinflammatory and profibrotic genes and upregulated antioxidant defenses and fatty acid oxidation in the liver. The hepatoprotective effects of α-DBI were mimicked by the induction of ACBP/DBI-specific autoantibodies, an inducibleAcbp/Dbiknockout or a constitutiveGabrg2F77Imutation that abolishes ACBP/DBI binding to the GABAAreceptor. Liver-protective α-DBI effects were lost when autophagy was pharmacologically blocked or genetically inhibited by knockout ofAtg4b. Of note, α-DBI also reduced myocardium infarction and lung fibrosis, supporting the contention that it mediates broad organ-protective effects against multiple insults.
|
|
| 9. |
- Motino, O, et al.
(författare)
-
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
- 2022
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:41, s. e2207344119-
-
Tidskriftsartikel (refereegranskat)abstract
- Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a monoclonal antibody neutralizing ACBP/DBI (α-DBI) protects the murine liver against ischemia/reperfusion damage, intoxication by acetaminophen and concanavalin A, and nonalcoholic steatohepatitis caused by methionine/choline-deficient diet as well as against liver fibrosis induced by bile duct ligation or carbon tetrachloride. α-DBI downregulated proinflammatory and profibrotic genes and upregulated antioxidant defenses and fatty acid oxidation in the liver. The hepatoprotective effects of α-DBI were mimicked by the induction of ACBP/DBI-specific autoantibodies, an inducibleAcbp/Dbiknockout or a constitutiveGabrg2F77Imutation that abolishes ACBP/DBI binding to the GABAAreceptor. Liver-protective α-DBI effects were lost when autophagy was pharmacologically blocked or genetically inhibited by knockout ofAtg4b. Of note, α-DBI also reduced myocardium infarction and lung fibrosis, supporting the contention that it mediates broad organ-protective effects against multiple insults.
|
|
| 10. |
|
|
