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- Borrazzo, Cristian, et al.
(författare)
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PET and MRI-guided focused ultrasound surgery for Neurological Applications
- 2016
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Ingår i: 2016 IEEE NUCLEAR SCIENCE SYMPOSIUM, MEDICAL IMAGING CONFERENCE AND ROOM-TEMPERATURE SEMICONDUCTOR DETECTOR WORKSHOP (NSS/MIC/RTSD). - : IEEE. - 9781509016426
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Konferensbidrag (refereegranskat)abstract
- Magnetic Resonance (MR) guided Focused Ultrasound Surgery (MRgFUS) technology, combined with High Intensity Focused Ultrasound (HIFU) beams, has opened to new therapeutic protocols for various pathological conditions. The success of this therapy relies on the accuracy of the guidance for therapy provided by thermal mapping of sonication, which is obtained with MR imaging. In addition, in recent years, multimodality Positron Emission Tomography and Magnetic Resonance Imaging (PET/MRI) imaging has been developed. This technique is able to provide simultaneous functional and soft tissue morphological imaging and, for this reason, it is particularly engaging for brain imaging. The key concept behind this work is to assess the feasibility of a brain-dedicated PET-and MRI-guided FUS device providing real-time evaluation of the outcome of the HIFU therapy. At first, a method to improve imaging capabilities of small-ring PET scanners will be presented. It will be showed that thanks to this method it is possible to obtain high tomographic spatial resolution with an affordable, brain-dedicated, PET scanner based on monolithic scintillation crystals and able to work as an insert in a MRI system. Moreover, simulations of an anthropomorphic phantom will be made in order to evaluate the effect of different HIFU protocols and, in addition, to investigate the capability of thermal maps provided by MRI for assessing the effect of the HIFU treatment. Finally, from the comparison of the spatial resolutions provided by each imaging technique (PET, MRI and thermal MRI) and the HIFU therapy, it will be possible to assess the feasibility of the proposed multimodality device. The system suggested in this work should be composed of a MRI scanner with a PET insert and a customized MRI-compatible focused ultrasound applicator. It could be very useful for the diagnosis and therapy of brain tumors thanks to the possibility of a real-time evaluation of the effect of the HIFU treatment. The protocol for the therapy could be executed in three main steps: the diagnosis of the pathological condition by means of fused anatomical imaging from MRI and functional imaging from PET (with different radiotracers) that allow to identify the region where apply the therapy, the ablation of the tumor by means of HIFU beams and the simultaneous evaluation of the thermal response of the tissues by means MRI thermal maps and, finally, the assessment of the outcome of the therapy by means, again, of PET/MRI hybrid imaging. The results suggest that PET and MRI-guided focused ultrasound surgery (PET/MRgFUS) could be an innovative, feasible and engaging technique for tumor ablation in the brain.
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| 2. |
- Bousquet, Jean, et al.
(författare)
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ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
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Forskningsöversikt (refereegranskat)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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| 3. |
- Bousquet, J. Jean, et al.
(författare)
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Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases
- 2019
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Ingår i: Clinical and Translational Allergy. - : BMC. - 2045-7022. ; 9
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Forskningsöversikt (refereegranskat)abstract
- Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy.Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care.Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
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| 4. |
- Santoro, Aurelia, et al.
(författare)
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Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study
- 2019
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Ingår i: European Radiology. - : Springer. - 0938-7994 .- 1432-1084. ; 29:9, s. 4968-4979
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.METHODS: A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65-79 years) women and men from five European countries of the "New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe" project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays.RESULTS: BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.CONCLUSIONS: The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.KEY POINTS: • Body composition markers concordantly associated positively or negatively with adipose-related and inflammatory markers, with the exception of skeletal muscle mass index. • No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, gp130, TNF-α-R1, and TNF-α-R2. • Skeletal muscle mass index (SMI) shows a good correlation with inflammatory profile in age-related sarcopenia.
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