| 1. |
- Cottrell, Richard, et al.
(författare)
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Food production shocks across land and sea
- 2019
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Ingår i: Nature Sustainability. - : Springer Science and Business Media LLC. - 2398-9629. ; 2, s. 130-137
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Tidskriftsartikel (refereegranskat)abstract
- Sudden losses to food production (that is, shocks) and their consequences across land and sea pose cumulative threats to global sustainability. We conducted an integrated assessment of global production data from crop, livestock, aquaculture and fisheries sectors over 53 years to understand how shocks occurring in one food sector can create diverse and linked challenges among others. We show that some regions are shock hotspots, exposed frequently to shocks across multiple sectors. Critically, shock frequency has increased through time on land and sea at a global scale. Geopolitical and extreme-weather events were the main shock drivers identified, but with considerable differences across sectors. We illustrate how social and ecological drivers, influenced by the dynamics of the food system, can spill over multiple food sectors and create synchronous challenges or trade-offs among terrestrial and aquatic systems. In a more shock-prone and interconnected world, bold food policy and social protection mechanisms that help people anticipate, cope with and recover from losses will be central to sustainability. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
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| 2. |
- Cottrell, Richard S., et al.
(författare)
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Time to rethink trophic levels in aquaculture policy
- 2021
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Ingår i: Reviews in Aquaculture. - : Wiley. - 1753-5123 .- 1753-5131. ; 13:3, s. 1583-1593
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Tidskriftsartikel (refereegranskat)abstract
- Aquaculture policy often promotes production of low-trophic level species for sustainable industry growth. Yet, the application of the trophic level concept to aquaculture is complex, and its value for assessing sustainability is further complicated by continual reformulation of feeds. The majority of fed farmed fish and invertebrate species are produced using human-made compound feeds that can differ markedly from the diet of the same species in the wild and continue to change in composition. Using data on aquaculture feeds, we show that technical advances have substantially decreased the mean effective trophic level of farmed species, such as salmon (mean TL = 3.48 to 2.42) and tilapia (2.32 to 2.06), from 1995 to 2015. As farmed species diverge in effective trophic level from their wild counterparts, they are coalescing at a similar effective trophic level due to standardisation of feeds. This pattern blurs the interpretation of trophic level in aquaculture because it can no longer be viewed as a trait of the farmed species, but rather is a dynamic feature of the production system. Guidance based on wild trophic position or historical resource use is therefore misleading. Effective aquaculture policy needs to avoid overly simplistic sustainability indicators such as trophic level. Instead, employing empirically derived metrics based on the specific farmed properties of species groups, management techniques and advances in feed formulation will be crucial for achieving truly sustainable options for farmed seafood.
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| 3. |
- Gilthorpe, Jonathan, et al.
(författare)
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Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia.
- 2013
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Ingår i: F1000Research. - : F1000 Research Ltd. - 2046-1402. ; 2:148
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Tidskriftsartikel (refereegranskat)abstract
- In neurodegenerative conditions and following brain trauma it is not understood why neurons die while astrocytes and microglia survive and adopt pro-inflammatory phenotypes. We show here that the damaged adult brain releases diffusible factors that can kill cortical neurons and we have identified histone H1 as a major extracellular candidate that causes neurotoxicity and activation of the innate immune system. Extracellular core histones H2A, H2B H3 and H4 were not neurotoxic. Innate immunity in the central nervous system is mediated through microglial cells and we show here for the first time that histone H1 promotes their survival, up-regulates MHC class II antigen expression and is a powerful microglial chemoattractant. We propose that when the central nervous system is degenerating, histone H1 drives a positive feedback loop that drives further degeneration and activation of immune defences which can themselves be damaging. We suggest that histone H1 acts as an antimicrobial peptide and kills neurons through mitochondrial damage and apoptosis.
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