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- Alcala, Karine, et al.
(författare)
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The relationship between blood pressure and risk of renal cell carcinoma
- 2022
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 1464-3685 .- 0300-5771. ; 51:4, s. 1317-1327
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.METHODS: Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP.RESULTS: In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10-1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91-1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08-1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56-0.88) for genetically predicted SBP.CONCLUSION: The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP.
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| 2. |
- Nesheli, Dariush Nasrollahzadeh
(författare)
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Risk factors for esophageal squamous cell carcinoma
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Aims: The etiology of esophageal squamous cell carcinoma (ESCC) in the high risk areas is largely unknown and a few environmental risk factors which have been identified do not explain its oddly high incidence in esophageal cancer belt. The aims of this thesis were to investigate the association of opium/tobacco consumption, serologic gastric atrophy, gastric mucosa-associated microbiota and contact with farm animals with the risk of ESCC. Methods: The population of Golestan Province in northeastern Iran has very high rates of ESCC. From 2003 to 2007, we administered a validated structured questionnaire to 300 incident ESCC cases and 571 controls. Controls were matched to cases for neighborhood of residence, age (± 2 years), and sex. We measured serum pepsinogen I and II among 293 incident cases and 524 matched controls. Conditional logistic regression models were applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential confounders. Furthermore we obtained a frozen gastric tissue biopsy from subjects with ESCC, esophageal squamous dysplasia, mid esophagus esophagitis, and age/sex-matched endoscopy clinic controls with healthy esophagus. To characterize bacterial lineage present in gastric mucosa, we performed a multiplex sequencing with GS-FLX Titanium targeting 16S rRNA. Results: Risk of ESCC was increased in those who used opium only (OR = 2.12, 95% CI: 1.21 - 3.74), and in those who used both tobacco and opium (2.35, 95% CI: 1.50 - 3.67). All forms of tobacco use (cigarettes, hookah, and nass) were associated with higher ESCC risk. Gastric atrophy (defined by a validated criterion, pepsinogen I <55 μg/dl) was associated with a two-fold increased risk (OR = 2.01, 95% CI: 1.18 - 3.45) of ESCC in the absence of non-atrophic pangastritis (defined as pepsinogen II < 11.8 μg/dl). Sequencing of 16S rRNA in gastric biopsy samples resulted 2075 operational taxonomic units (OTUs). Conditional logistic regression model based on principal coordinate analysis (PCoA) showed a marginal variation in pattern of gastric microbiota using Unifrac (p = 0.004) and weighted Unifrac distances (p = 0.018) between subjects with esophageal cancer or dysplasia and controls. No such difference between subjects with mid-esophagitis and controls was observed. Among four groups of farm animals (equines, ruminants, domestic canine and poultry) contact with ruminants was associated with an 8-fold increase in risk of ESCC. This association stayed stable when duration and level of contact were considered. Conclusions: Though opium and tobacco consumption are associated with the risk of ESCC in the study area, they do not explain the extreme high incidence in northern Iran. Changes in gastric environment might be linked to ESCC risk as fundal atrophy may increase the risk for ESCC and pattern of gastric microbiota differs in patients with esophageal squamous dysplasia (and ESCC) from subjects with normal esophagus. The observed relationship between lifelong contact with ruminants and ESCC needs further investigation.
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