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  • Durevall, Dick, 1954, et al. (author)
  • A Dynamic Model of Inflation for Kenya 1974 - 1996
  • 1998
  • Reports (other academic/artistic)abstract
    • This paper develops an error correction model with the aim of analysing the behaviour of prices in Kenya during 1974 -1996. In estimating the model, we first test for cointegration in the money and foreign exchange markets, using the Johansen procedure. The cointegrating vectors are then included in an autoregressive distributed-lag model, and a general-to-specific procedure is applied to obtain a parsimonious, empirically constant, error correction model. We find that in the long run inflation emanates from movements in the exchange rate, foreign prices, and terms of trade. The error correction term for the monetary sector does not enter the model, but money supply and the interest rate influence inflation in the short run. Inflation inertia is found to be an important determinant of inflation up until 1993, when about 400f the current inflation is carried over to the next quarter. After 1993, inertia drops to about 10%. The dynamics of inflation are also influenced by food supply constraints, proxied by maize-price inflation. These findings indicate that the exchange rate is likely to be a more efficient nominal anchor than money supply, and that inflation could be made more stable by policies that secure the supply of maize during droughts.
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  • Vianello, Eleonora, et al. (author)
  • Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP
  • 2023
  • In: iScience. - 2589-0042. ; 26:12
  • Journal article (peer-reviewed)abstract
    • The vectored Ebola vaccine rVSVΔG-ZEBOV-GP elicits protection against Ebola Virus Disease (EVD). In a study of forty-eight healthy adult volunteers who received either the rVSVΔG-ZEBOV-GP vaccine or placebo, we profiled intracellular microRNAs (miRNAs) from whole blood cells (WB) and circulating miRNAs from serum-derived extracellular vesicles (EV) at baseline and longitudinally following vaccination. Further, we identified early miRNA signatures associated with ZEBOV-specific IgG antibody responses at baseline and up to one year post-vaccination, and pinpointed target mRNA transcripts and pathways correlated to miRNAs whose expression was altered after vaccination by using systems biology approaches. Several miRNAs were differentially expressed (DE) and miRNA signatures predicted high or low IgG ZEBOV-specific antibody levels with high classification performance. The top miRNA discriminators were WB-miR-6810, EV-miR-7151-3p, and EV-miR-4426. An eight-miRNA antibody predictive signature was associated with immune-related target mRNAs and pathways. These findings provide valuable insights into early blood biomarkers associated with rVSVΔG-ZEBOV-GP vaccine-induced IgG antibody responses.
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  • Result 1-7 of 7

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