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- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
- Khatri, C, et al.
(författare)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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- Ejjeh, Adel, et al.
(författare)
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HPVM2FPGA: Enabling True Hardware-Agnostic FPGA Programming
- 2022
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Ingår i: IEEE 33rd International Conference on Application-specific Systems, Architectures and Processors (ASAP). - 9781665483087 - 9781665483094
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Konferensbidrag (refereegranskat)abstract
- Current FPGA programming tools require extensive hardware-specific manual code tuning to achieve performance, which is intractable for most software application teams. We present HPVM2FPGA, a novel end-to-end compiler and autotuning system that can automatically tune hardware-agnostic programs for FPGAs. HPVM2FPGA uses a hardware-agnostic abstraction of parallelism as an intermediate representation (IR) to represent hardware-agnostic programs. HPVM2FPGA’s powerful optimization framework uses sophisticated compiler optimizations and design space exploration (DSE) to automatically tune a hardware-agnostic program for a given FPGA. HPVM2FPGA is able to support software programmers by shifting the burden of performing hardware-specific optimizations to the compiler and DSE. We show that HPVM2FPGA can achieve up to 33× speedup compared to unoptimized baselines and can match the performance of hand-tuned HLS code for three of four benchmarks. We have designed HPVM2FPGA to be a modular and extensible framework, and we expect it to match handtuned code for most programs as the system matures with more optimizations. Overall, we believe that it constitutes a solid step closer to fully hardware-agnostic FPGA programming, making it a suitable cornerstone for future FPGA compiler research.
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