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Sökning: WFRF:(Nesheim S)

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  • Hveem, T. S., et al. (författare)
  • Changes in Chromatin Structure in Curettage Specimens Identifies High-Risk Patients in Endometrial Cancer
  • 2017
  • Ingår i: Cancer Epidemiology Biomarkers & Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 26:1, s. 61-67
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Most endometrial carcinoma patients are diagnosed at an early stage with a good prognosis. However, a relatively low fraction with lethal disease constitutes a substantial number of patients due to the high incidence rate. Preoperative identification of patients with high risk and low risk for poor outcome is necessary to tailor treatment. Nucleotyping refers to characterization of cell nuclei by image cytometry, including the assessment of chromatin structure by nuclear texture analysis. This method is a strong prognostic marker in many cancers but has not been evaluated in preoperative curettage specimens from endometrial carcinoma. Methods: The prognostic impact of changes in chromatin structure quantified with Nucleotyping was evaluated in preoperative curettage specimens from 791 endometrial carcinoma patients prospectively included in the MoMaTEC multicenter trial. Results: Nucleotyping was an independent prognostic marker of disease-specific survival in preoperative curettage specimens among patients with Federation Internationale des Gynaecologistes et Obstetristes (FIGO) stage I-II disease (HR = 2.9; 95% CI, 1.2-6.5; P - 0.013) and significantly associated with age, FIGO stage, histologic type, histologic grade, myometrial infiltration, lymph node status, curettage histology type, and DNA ploidy. Conclusions: Nucleotyping in preoperative curettage specimens is an independent prognostic marker for disease-specific survival, with potential to supplement existing parameters for risk stratification to tailor treatment. Impact: This is the first study to evaluate the prognostic impact of Nucleotyping in curettage specimens from endometrial carcinoma and shows that this may be a clinically useful prognostic marker in endometrial cancer. External validation is warranted. (C) 2016 AACR.
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  • Stålnacke, Per, et al. (författare)
  • Integrated Water Resources Management : STRIVER efforts to assess the current status and future possibilities in four river basins
  • 2011
  • Ingår i: European research on sustainable development. Vol. 1, Transformative science approaches for sustainability. - : Springer Publishing Company. - 9783642192012 ; , s. 155-172
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • This book provides the reader with a state-of-the-art view of research on sustainable development. Its emphasis lies on the transformative dimension of this research: sustainable development can only be realized through a far-reaching transformation of the situation humankind finds itself in at the beginning of the third millennium. The contributions are written by leading world experts in the conceptualisation and actual practice of sustainable development. The book provides a timely overview of ideas and methods as well as a variety of original learning examples on the most innovative approaches on sustainability science
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  • Resultat 1-3 av 3

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