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| 2. |
- Nessvi, Sofia, et al.
(författare)
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Association of 25-Hydroxyvitamin D(3) Levels in Adult New Zealanders with Ethnicity, Skin Color and Self-Reported Skin Sensitivity to Sun Exposure
- 2011
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Ingår i: Photochemistry and Photobiology. - : Wiley-Blackwell. - 0031-8655 .- 1751-1097. ; 87:5, s. 1173-1178
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Tidskriftsartikel (refereegranskat)abstract
- The study aim was to determine the contribution of ethnicity, objectively measured skin color and skin reaction-to-sun exposure to variations in 25-hydroxyvitamin D(3) [25(OH)D(3)]. A multiethnic sample (European, Maori, Pacific and Asian) of 503 adult volunteers aged 18-85 years, recruited from Auckland and Dunedin in New Zealand, answered a questionnaire on sun exposure and self-defined ethnicity. Skin color was measured using a spectrophotometer and the Individual Typology Angle (ITA) calculated. A blood sample was collected 4 weeks later to measure 25(OH)D(3). 25(OH)D(3) was associated with ethnicity, but not self-reported skin reaction-to-sun exposure. Amongst the ethnic groups, Asians had the lowest mean 25(OH)D level (37.0 nmol L(-1)) and Europeans with lighter colored skin had the highest (57.9 nmol L(-1)). An association also was seen between 25(OH)D(3) and skin color, with an increase of 2-3 nmol L(-1) per 10 degrees increase in ITA value, indicating higher 25(OH)D(3) with lighter skin color; but much of this association disappeared after adjusting for ethnicity. In contrast, ethnicity remained associated with 25(OH)D(3) after adjusting for ITA skin color and skin reaction-to-sun exposure. These results indicate that self-defined ethnicity was a major determinant of variations in serum 25(OH)D(3), while objective measures of skin color explained relatively little additional variation.
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| 3. |
- Nessvi, Sofia, et al.
(författare)
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Impact of preoperative evaluation by vascular physician on mortality in patients undergoing elective endovascular repair for abdominal aortic aneurysm.
- 2015
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Ingår i: International Angiology. - 1827-1839. ; 35:6, s. 579-585
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Abdominal aortic aneurysm (AAA) is a potentially life-threatening condition associated with increased cardiovascular mortality. This study aims to evaluate effects of medical assessment prior to endovascular repair (EVAR) for AAAon long term survival and causes of death. METHODS: Aretrospective study comparing patients treated with EVARfor AAAfrom 1998 to 2006, having undergone standardized preoperative work-up including spirometry and echocardiography (group 1, N.=304), to patients undergoing EVAR2007 to 2011 after individual assessment by a vascular physician aiming to optimize cardiovascular medication and reveal previously unknown illnesses (group 2, N.=201). Median follow-up was 84 months (Inter Quartile Range [IQR] 40-84) in group 1, and 60 months (IQR45-75) in group 2. RESULTS: The use of lipid lowering agents (92%; P<0.001), anti-platelet (85%; P<0.001), antihypertensive drugs (94%; P<0.001), and beta receptor blockers (78%; P<0.001) was higher in group 2. In multivariable analysis adjusting for AAA-size ≥6.0 cm, signs of ischemia on ECG, and chronic kidney disease stage ≥3, group 1 had significantly higher both 1-year (OR 3.2 [95% CI 1.2-9.0]) and 2-year mortality (OR 2.3 [95% CI 1.2-4.6]), whereas no differences were found between groups in survival beyond 2 years. Vascular disease was the most common cause of death in both groups (62% and 55%; P=0.29). CONCLUSIONS: Individualized preoperative evaluation by a vascular physician prior to elective EVARwas associated with reduced 1- and 2-year mortality, presumably related to more effective pharmacological cardiovascular prevention.
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| 4. |
- Nessvi, Sofia, et al.
(författare)
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Inflammatory mediators after endovascular aortic aneurysm repair.
- 2014
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Ingår i: Cytokine. - : Elsevier BV. - 1096-0023 .- 1043-4666. ; 70:2, s. 151-155
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Tidskriftsartikel (refereegranskat)abstract
- To evaluate patterns of inflammatory mediators before and after elective endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA).
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| 5. |
- Ohrlander, T., et al.
(författare)
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Influence of preoperative medical assessment prior to elective endovascular aneurysm repair for abdominal aortic aneurysm
- 2012
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Ingår i: International Angiology. - 1827-1839. ; 31:4, s. 368-375
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Tidskriftsartikel (refereegranskat)abstract
- Aim. The aim of this study was to compare preoperative patient evaluation by a vascular physician with a standardized workup protocol prior to elective endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA), in terms of differences in patient medication and mortality. Methods. Consecutive patients with infrarenal AAA treated with standard EVAR from 1998 to 2006 (group 2) and 2007 to 2011 (group 1) were compared. Patients in group 1 (N.=201) were investigated preoperatively by a vascular physician, evaluating comorbidities and medication. Patients in group 2 (N.=304) underwent a standardized preoperative work-up including spirometry and echocardiography. Median time of follow-up was 23 months in group 1 and 71 months in group 2. Results. The proportion of patients who had on-going medication with anti-platelet and lipid lowering medication at admission was higher in group 1 compared to group 2 (62% versus 51%; P=0.013 and 68% versus 35%; P<0.001). In group 1, the proportion of newly instituted or increased dosage of anti-hypertensive, anti-platelet or lipid lowering medication at preoperative evaluation was 40%, 24% and 31%, respectively. The total cost for preoperative assessment per patient was 272 (sic) in group 1 and 293 (sic) in group 2 (P<0.001). There was no difference in 30-day (P=0.29) or long-term (P.0.24) mortality between the two groups. Conclusion. Preoperative assessment by a vascular physician resulted in lower costs and improvement of medication against atherosclerosis, uncontrolled hypertension and perioperative ischemic cardiac events, but mortality was unaffected. [Int Angiol 2012;31:368-75]
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| 6. |
- Otterhag, Sofia Nessvi, et al.
(författare)
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Decreasing incidence of ruptured abdominal aortic aneurysm already before start of screening.
- 2016
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Ingår i: BMC Cardiovascular Disorders. - : Springer Science and Business Media LLC. - 1471-2261. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The aim of this study was to evaluate whether screening for abdominal aortic aneurysm (AAA) has led to a decrease in ruptured AAA (rAAA) incidence. METHOD: The Malmö population was evaluated regarding the incidence of rAAA and elective AAA surgery 4 years before and after start of AAA-screening in 2010. Data from 1971 to 1986 (J Vasc Surg 18:74-80, 1993) and 2000-2004 (J Vasc Surg 44:237-43, 2006), enabled analysis of trends over time. RESULTS: Analysis of time-periods 1971-1986, 2000-2004, 2006-2010 and 2010-2014 showed an incidence of rAAA of 5.6 (4.9-6.3), 10.6 (8.9-12.4), 6.1 (4.6-7.6) and 4.0 (2.9-5.1), respectively. In men aged 60-69 years the incidences were 16.0 (10.7-21.3), 45.6 (27.7-63.4), 19.3 (9.2-35.3) and 8.9 (2.8-20.6), respectively. The incidences of elective AAA surgery in men aged 60-69 years were 22.9 (16.5-29.2), 34.6 (19.1-50.2), 9.7 (1.2-18.5) and 44.2 (27.0-61.6), respectively. CONCLUSIONS: A decrease in incidence of rAAA in men was evident before the implementation of screening. We were yet not able to demonstrate a certain reduction in rAAA incidence after the start of screening.
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