| 1. |
- Botzanowski, Boris, et al.
(författare)
-
Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields
- 2022
-
Ingår i: Advanced Healthcare Materials. - : Wiley. - 2192-2640 .- 2192-2659. ; 11:17
-
Tidskriftsartikel (refereegranskat)abstract
- Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.
|
|
| 2. |
- Missey, Florian, et al.
(författare)
-
Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference
- 2023
-
Ingår i: Bioelectronic Medicine. - : BioMed Central (BMC). - 2332-8886. ; 9:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Peripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep nerve targets and the stimulation focality to offer selectivity. It is therefore rarely employed as the primary selected nerve stimulation method. We have previously demonstrated that a new stimulation technique, temporal interference stimulation, can overcome depth and focality issues.Methods: Here, we implement a novel form of temporal interference, bilateral temporal interference stimulation, for bilateral hypoglossal nerve stimulation in rodents and humans. Pairs of electrodes are placed alongside both hypoglossal nerves to stimulate them synchronously and thus decrease the stimulation amplitude required to activate hypoglossal-nerve-controlled tongue movement.Results: Comparing bilateral temporal interference stimulation with unilateral temporal interference stimulation, we show that it can elicit the same behavioral and electrophysiological responses at a reduced stimulation amplitude. Traditional transcutaneous stimulation evokes no response with equivalent amplitudes of stimulation.Conclusions: During first-in-man studies, temporal interference stimulation was found to be well-tolerated, and to clinically reduce apnea-hypopnea events in a subgroup of female patients with obstructive sleep apnea. These results suggest a high clinical potential for the use of temporal interference in the treatment of obstructive sleep apnea and other diseases as a safe, effective, and patient-friendly approach.Trial registration: The protocol was conducted with the agreement of the International Conference on Harmonisation Good Clinical Practice (ICH GCP), applicable United States Code of Federal Regulations (CFR) and followed the approved BRANY IRB File # 22-02-636-1279.
|
|
| 3. |
- Paulides, M. M., et al.
(författare)
-
ESHO benchmarks for computational modeling and optimization in hyperthermia therapy
- 2021
-
Ingår i: International Journal of Hyperthermia. - : Informa UK Limited. - 0265-6736 .- 1464-5157. ; 38:1, s. 1425-1442
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The success of cancer hyperthermia (HT) treatments is strongly dependent on the temperatures achieved in the tumor and healthy tissues as it correlates with treatment efficacy and safety, respectively. Hyperthermia treatment planning (HTP) simulations have become pivotal for treatment optimization due to the possibility for pretreatment planning, optimization and decision making, as well as real-time treatment guidance. Materials and methods: The same computational methods deployed in HTP are also used for in silico studies. These are of great relevance for the development of new HT devices and treatment approaches. To aid this work, 3 D patient models have been recently developed and made available for the HT community. Unfortunately, there is no consensus regarding tissue properties, simulation settings, and benchmark applicators, which significantly influence the clinical relevance of computational outcomes. Results and discussion: Herein, we propose a comprehensive set of applicator benchmarks, efficacy and safety optimization algorithms, simulation settings and clinical parameters, to establish benchmarks for method comparison and code verification, to provide guidance, and in view of the 2021 ESHO Grand Challenge (Details on the ESHO grand challenge on HTP will be provided at https://www.esho.info/). Conclusion: We aim to establish guidelines to promote standardization within the hyperthermia community such that novel approaches can quickly prove their benefit as quickly as possible in clinically relevant simulation scenarios. This paper is primarily focused on radiofrequency and microwave hyperthermia but, since 3 D simulation studies on heating with ultrasound are now a reality, guidance as well as a benchmark for ultrasound-based hyperthermia are also included.
|
|
| 4. |
- Vogiatzis Oikonomidis, Ioannis, 1989, et al.
(författare)
-
Couple Electromagnetic and Neuronal Dynamics Simulation of Gradient Coil Switching Induced Nerve Stimulation
- 2014
-
Ingår i: Proceedings: Joint Annual Meeting ISMRM-ESMRMB 2014
SMRT 23rd Annual Meeting 10-16 May, 2014 Milan Italy. ; , s. paper 1388-
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Nerve stimulation by rapidly switching gradient coils is a safety concern in MR. An EM and thermal simulation platform has been coupled with a neuronal dynamics modeling code, to investigate such interactions in realistic anatomical models. A locally temperature dependent variant of the SENN model, commonly employed for safety threshold assessment, has been developed. Modeling of sciatic nerve stimulation by gradient coil switching, considering the impact of RF birdcage coil induced heating, showed that the model anisotropy, the field variation along the nerve and local temperature have a relevant impact that can be studied using the coupled EM-neuron simulation platform.
|
|
