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Sökning: WFRF:(Neumann Norbert)

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1.
  • Ahrens, Norbert, et al. (författare)
  • Mesenchymal stem cell content of human vertebral bone marrow
  • 2004
  • Ingår i: Transplantation. - 1534-6080. ; 78:6, s. 925-929
  • Tidskriftsartikel (refereegranskat)abstract
    • Mesenchymal stem cells (MSCs) are capable of down-regulating alloimmune responses and promoting the engraftment of hematopoietic stem cells. MSCs may therefore be suitable for improving donor-specific tolerance induction in solid-organ transplantation. Cells from cadaveric vertebral bone marrow (V-BM), aspirated iliac crest-BM, and peripheral blood progenitor cells were compared. Cells were characterized by flow cytometry and colony assays. MSCs generated from V-BM were assayed for differentiation capacity and immunomodulatory function. A median 5.7 x 10(8) nucleated cells (NCs) were recovered per vertebral body. The mesenchymal progenitor, colony-forming unit-fibroblast, frequency in V-BM (11.6/10(5) NC, range: 6.0-20.0) was considerably higher than in iliac crest-BM (1.4/10(5) NC, range: 0.4-2.6) and peripheral blood progenitor cells (not detectable). MSC generated from V-BM had the typical MSC phenotype (CD105(pos)CD73(pos)CD45(neg)CD34(neg)), displayed multilineage differentiation potential, and suppressed alloreactivity in mixed lymphocyte reactions. V-BM may be an excellent source for MSC cotransplantation approaches.
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3.
  • Schiefer, Christoph, et al. (författare)
  • PEPPA - Exchange Platform for Measurements of Occupational Physical Activity and Physical Workload
  • 2022
  • Ingår i: Proceedings of the 21st Congress of the International Ergonomics Association, IEA 2021 : Methods and Approaches - Methods and Approaches. - Cham : Springer International Publishing. - 2367-3370 .- 2367-3389. - 9783030746131 ; 223 LNNS, s. 175-182, s. 175-182
  • Konferensbidrag (refereegranskat)abstract
    • Technical measurements allow an objective assessment of MSD risk factors at work. There is a need for common standards regarding data collection and processing, as well as an exchange platform storing measurement data of occupational physical activity and workload for further analysis. Several research institutes started a feasibility study to work on developing standards for assessment of risk factors and implement them in an exchange platform prototype. The first prototype already demonstrates a technical feasibility. Coordination and structure of the contents, as well as estimates of costs and efforts needed for further development need more examination in order to arrive at a final platform with good feasibility.
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