| 1. |
- von Seidlein, Lorenz, et al.
(författare)
-
The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial
- 2019
-
Ingår i: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 16:2
-
Tidskriftsartikel (refereegranskat)abstract
- Background The emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum malaria incidence and prevalence in 16 remote village populations in Myanmar, Vietnam, Cambodia, and the Lao Peoples Democratic Republic, where artemisinin resistance is prevalent. Methods and findings After establishing vector control and community-based case management and following intensive community engagement, we used restricted randomisation within village pairs to select 8 villages to receive early DP MDA and 8 villages as controls for 12 months, after which the control villages received deferred DP MDA. The MDA comprised 3 monthly rounds of 3 daily doses of DP and, except in Cambodia, a single low dose of primaquine. We conducted exhaustive cross-sectional surveys of the entire population of each village at quarterly intervals using ultrasensitive quantitative PCR to detect Plasmodium infections. The study was conducted between May 2013 and July 2017. The investigators randomised 16 villages that had a total of 8,445 residents at the start of the study. Of these 8,445 residents, 4,135 (49%) residents living in 8 villages, plus an additional 288 newcomers to the villages, were randomised to receive early MDA; 3,790 out of the 4,423 (86%) participated in at least 1 MDA round, and 2,520 out of the 4,423 (57%) participated in all 3 rounds. The primary outcome, P. falciparum prevalence by month 3 (M3), fell by 92% (from 5.1% [171/3,340] to 0.4% [12/2,828]) in early MDA villages and by 29% (from 7.2% [246/3,405] to 5.1% [155/3,057]) in control villages. Over the following 9 months, the P. falciparum prevalence increased to 3.3% (96/2,881) in early MDA villages and to 6.1% (128/2,101) in control villages (adjusted incidence rate ratio 0.41 [95% CI 0.20 to 0.84]; p = 0.015). Individual protection was proportional to the number of completed MDA rounds. Of 221 participants with subclinical P. falciparum infections who participated in MDA and could be followed up, 207 (94%) cleared their infections, including 9 of 10 with artemisinin-and piperaquine- resistant infections. The DP MDAs were well tolerated; 6 severe adverse events were detected during the follow-up period, but none was attributable to the intervention. Conclusions Added to community-based basic malaria control measures, 3 monthly rounds of DP MDA reduced the incidence and prevalence of falciparum malaria over a 1-year period in areas affected by artemisinin resistance. P. falciparum infections returned during the follow-up period as the remaining infections spread and malaria was reintroduced from surrounding areas. Limitations of this study include a relatively small sample of villages, heterogeneity between villages, and mobility of villagers that may have limited the impact of the intervention. These results suggest that, if used as part of a comprehensive, well-organised, and well-resourced elimination programme, DP MDA can be a useful additional tool to accelerate malaria elimination.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Baldi, Francesco, 1986, et al.
(författare)
-
Energy and exergy analysis of a cruise ship
- 2015
-
Ingår i: Proceedings of ECOS 2015 - the 28th International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems. - Pau : Pau University. - 9782955553909
-
Konferensbidrag (refereegranskat)abstract
- The shipping sector is today facing numerous challenges. Fuel prices are expected to increase in the medium-long term, and a sharp turn in environmental regulations will require several companies to switch to more expensive distillate fuels. In this context, passenger ships represent a small but increasing share of the industry. The complexity of the energy system of a ship where the energy required by propulsion is no longer the trivial main contributor to the whole energy use thus makes this kind of ship of particular interest for the analysis of how energy is converted from its original form to its final use on board.To illustrate this, we performed an analysis of the energy and exergy flow rates of a cruise ship sailing in the Baltic Sea based on a combination of available measurements from ship operations and of mechanistic knowledge of the system. The energy analysis allows identifying propulsion as the main energy user (41% of the total) followed by heat (34%) and electric power (25%) generation; the exergy analysis allowed instead identifying the main inefficiencies of the system: exergy is primarily destroyed in all processes involving combustion (88% of the exergy destruction is generated in the Diesel engines and in the oil-fired boilers) and in the sea water cooler (5.4%); the main exergy losses happen instead in the exhaust gas, mostly from the main engines (67% of total losses) and particularly from those not equipped with heat recovery devices.The improved understanding which derives from the results of the energy and exergy analysis can be used as a guidance to identify where improvements of the systems should be directed.
|
|
| 5. |
- Baldi, Francesco, 1986, et al.
(författare)
-
Energy and exergy analysis of a cruise ship
- 2018
-
Ingår i: Energies. - Basel, Switzerland : MDPI. - 1996-1073. ; 11:10, s. 1-41
-
Tidskriftsartikel (refereegranskat)abstract
- In recent years, the International Maritime Organization agreed on aiming to reduce shipping’s greenhouse gas emissions by 50% with respect to 2009 levels. Meanwhile, cruise ship tourism is growing at a fast pace, making the challenge of achieving this goal even harder. The complexity of the energy system of these ships makes them of particular interest from an energy systems perspective. To illustrate this, we analyzed the energy and exergy flow rates of a cruise ship sailing in the Baltic Sea based on measurements from one year of the ship’s operations. The energy analysis allows identifying propulsion as the main energy user (46% of the total) followed by heat (27%) and electric power (27%) generation; the exergy analysis allowed instead identifying the main inefficiencies of the system: while exergy is primarily destroyed in all processes involving combustion (76% of the total), the other main causes of exergy destruction are the turbochargers, the heat recovery steam generators, the steam heaters, the preheater in the accommodation heating systems, the sea water coolers, and the electric generators; the main exergy losses take place in the exhaust gas of the engines not equipped with heat recovery devices. The application of clustering of the ship’s operations based on the concept of typical operational days suggests that the use of five typical days provides a good approximation of the yearly ship’s operations and can hence be used for the design and optimization of the energy systems of the ship.
|
|
| 6. |
- Baldi, Francesco, 1986, et al.
(författare)
-
The application of process integration to the optimisation of cruise ship energy systems: A case study
- 2016
-
Ingår i: ECOS 2016 - Proceedings of the 29th International Conference on Efficiency, Cost, Optimisation, Simulation and Environmental Impact of Energy Systems. - 9789616980159
-
Konferensbidrag (refereegranskat)abstract
- In recent years, the shipping industry has faced an increasing number of challenges in terms of fluctuating fuel prices, stricter environmental regulations, and concerns about global warming. In this situation, passenger volumes on cruise ships have increased from around 4 million to 13 million from 1990 to 2008 and keep growing today. A small cruise ship can emit about 85 tons of CO2 per day, and require around 27 tons of fuel per day. To keep up with market demand, while reducing their impact on the environment, cruise ships will need to improve their energy efficiency. Most previous research in marine technology relates to energy efficiency focused on propulsion, which for most ship types constitutes the largest energy demand. On cruise ships, however, auxiliary heat and electric power also have a significant importance. For this reason, we focus in this paper on the heat demand and its integration with available sources of waste heat on board. In this study, the principles of process integration are applied to the energy system of a cruise ship operating in the Baltic Sea. The heat sources (waste heat from the main and auxiliary engines in form of exhaust gas, cylinder cooling, charge air cooling, and lubricating oil cooling) and sinks (HVAC, hot water, fuel heating) are evaluated based on one year of operational data and used to generate four operating conditions that best represent ship operations. Applying the pinch analysis to the system revealed that the theoretical potential for heat integration on board could potentially allow the reduction of the external heat demand by between 35% and 85% depending on the investigated case. A technoeconomic optimisation allowed the identification of the most economically viable heat exchanger network designs: two in the “retrofit” scenario and one in the “design” scenario, with a reduction of 13-33%, 15-27% and 46-56% of the external heat demand, respectively. Given the high amount of heat being available after the process integration, we also analysed the potential for the installation of a steam turbine for the recovery of the energy available in the exhaust gas, which resulted in up to 900 kW of power being available for on board electric power demand.
|
|
| 7. |
- Larsen, Ulrik, 1972, et al.
(författare)
-
Development of a multi-level approach to model and optimise the Kalina Split Cycle
- 2012
-
Ingår i: Proceedings of the 53rd SIMS conference on Simulation and Modelling.
-
Konferensbidrag (refereegranskat)abstract
- In the marine sector there is a strong motivation for increasing the propulsion system energy efficiency, mainly because of increasing fuel prices and stricter upcoming emission regulations. The Kalina cycle, based on a mixture of ammonia and water as working fluid, exhibits higher conversion efficiencies than conventional power cycles and could be suitable for this purpose. The Split Cycle technique provides a method to further increase the thermal efficiency, by reducing the thermodynamic losses in the heat recovery system. This is achieved by having two separate streams of different ammonia concentrations entering and leaving a first evaporator stage before being mixed at the inlet of a second evaporator stage. It seems that modelling efforts showing the advantages of the Split Cycle have not been presented in the literature yet. Thus, a thermodynamic model of the Split Cycle is introduced in this work. Modelling and optimisation of the rather complex cycle requires approaching the problem at different system levels. This paper investigates tools and methods suitable for demonstrating the feasibility and advantages of the Split Cycle. The integrated model developed and presented in this paper combines three sub-models all using the NIST REFPROP equations of state: a separator and mixing subsystem model to handle the inherent constraints of the Split Cycle, a component-based model to optimise the heat exchanger operating conditions, and a process model to investigate the complete thermodynamic cycle. Results suggest a 9% net power output increase and 7% higher thermal efficiency compared to the baseline case.
|
|
| 8. |
- Larsen, Ulrik, 1972, et al.
(författare)
-
System analysis and optimisation of a Kalina split-cycle for waste heat recovery on large marine diesel engines
- 2014
-
Ingår i: Energy. - 0360-5442 .- 1873-6785. ; 64
-
Tidskriftsartikel (refereegranskat)abstract
- Waste heat recovery systems can produce power from heat without using fuel or emitting CO2, therefore their implementation is becoming increasingly relevant. The Kalina cycle is proposed as an efficient process for this purpose. The main reason for its high efficiency is the non-isothermal phase change characteristics of the ammonia-water working fluid. The present study investigates a unique type of Kalina process called the Split-cycle, applied to the exhaust heat recovery from large marine engines. In the Split-cycle, the working fluid concentration can be changed during the evaporation process in order to improve the match between the heat source and working fluid temperatures. We present a system analysis to identify the governing mechanisms of the process, including a comparison of the efficiency of the Split-cycle and a conventional Kalina cycle and an investigation of the effects of using reheat in both cases. Results of a multi-variable optimisation effort using a genetic algorithm suggest that the Split-cycle process can obtain a thermal efficiency of 23.2% when using reheat compared to 20.8% for a conventional reference Kalina cycle. Reheat can increase the thermal efficiency by 3.4-5.9%. A simplified cost analysissuggests higher purchase costs as result of increased process complexity.
|
|
| 9. |
- Nguyen, Tuong-Van, 1988, et al.
(författare)
-
Thermodynamic evaluation of the Kalina split-cycle concepts for waste heat recovery applications
- 2014
-
Ingår i: Energy. - 0360-5442 .- 1873-6785. ; 71
-
Tidskriftsartikel (refereegranskat)abstract
- The Kalina split-cycle is a thermodynamic process for converting thermal energy into electrical power. It uses an ammonia–water mixture as a working fluid (like a conventional Kalina cycle) and has a varying ammonia concentration during the pre-heating and evaporation steps. This second feature results in an improved match between the heat source and working fluid temperature profiles, decreasing the entropy generation in the heat recovery system. The present work compares the thermodynamic performance of this power cycle with the conventional Kalina process, and investigates the impact of varying boundary conditions by conducting an exergy analysis. The design parameters of each configuration were determined by performing a multi-variable optimisation. The results indicate that the Kalina split-cycle with reheat presents an exergetic efficiency by 2.8% points higher than a reference Kalina cycle with reheat, and by 4.3% points without reheat. The cycle efficiency varies by 14% points for a variation of the exhaust gas temperature of 100 °C, and by 1% point for a cold water temperature variation of 30 °C. This analysis also pinpoints the large irreversibilities in the low-pressure turbine and condenser, and indicates a reduction of the exergy destruction by about 23% in the heat recovery system compared to the baseline cycle.
|
|
| 10. |
- Pierobon, L., et al.
(författare)
-
Multi-objective optimization of organic Rankine cycles for waste heat recovery: Application in an offshore platform
- 2013
-
Ingår i: Energy. - 0360-5442 .- 1873-6785. ; 58, s. 538-549
-
Tidskriftsartikel (refereegranskat)abstract
- This paper aims at finding the optimal design of MW-size organic Rankine cycles by employing the multi-objective optimization with the genetic algorithm as the optimizer. We consider three objective functions: thermal efficiency, total volume of the system and net present value. The optimization variables are the working fluid, the turbine inlet pressure and temperature, the condensing temperature, the pinch points and the fluid velocities in the heat exchangers. The optimization process also includes the complete design of the shell and tube heat exchangers utilized in the organic Rankine cycle. The methodology is applied to recover the waste heat from the SGT-500 gas turbine installed on the Draugen off-shore oil and gas platform in the North Sea. Results suggest two optimal working fluids, i.e. acetone and cyclopentane. Thermal efficiency and net present value are higher for cyclopentane than for acetone. Other promising working fluids are cyclohexane, hexane and isohexane. The present methodology can be utilized in waste heat recovery applications where a compromise between performance, compactness and economic revenue is required.
|
|
