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- Raposeiras-Roubin, Sergio, et al.
(författare)
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Development and external validation of a post-discharge bleeding risk score in patients with acute coronary syndrome : The BleeMACS score
- 2018
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Ingår i: International Journal of Cardiology. - : ELSEVIER IRELAND LTD. - 0167-5273 .- 1874-1754. ; 254, s. 10-15
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Tidskriftsartikel (refereegranskat)abstract
- Background: Accurate 1-year bleeding risk estimation after hospital discharge for acute coronary syndrome(ACS) may help clinicians guide the type and duration of antithrombotic therapy. Currently there are no predictive models for this purpose. The aim of this study was to derive and validate a simple clinical tool for bedside risk estimation of 1-year post-discharge serious bleeding in ACS patients.Methods: The risk score was derived and internally validated in the BleeMACS (Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome) registry, an observational international registry involving 15,401 patients surviving admission for ACS and undergoing percutaneous coronary intervention (PCI) from 2003 to 2014, engaging 15 hospitals from 10 countries located in America, Europe and Asia. External validation was conducted in the SWEDEHEART population, with 96,239 ACS patients underwent PCI and 93,150 without PCI.Results: Seven independent predictors of bleeding were identified and included in the BleeMACS score: age, hypertension, vascular disease, history of bleeding, malignancy, creatinine and hemoglobin. The BleeMACS risk score exhibited a C-statistic value of 0.71 (95% CI 0.68-0.74) in the derivation cohort and 0.72 (95% CI 0.67-0.76) in the internal validation sample. In the SWEDEHEART external validation cohort, the C-statistic was 0.65 (95% CI 0.64-0.66) for PCI patients and 0.63 (95% CI 0.62-0.64) for non-PCI patients. The calibration was excellent in the derivation and validation cohorts.Conclusions: The BleeMACS bleeding risk score is a simple tool useful for identifying those ACS patients at higher risk of serious 1-year post-discharge bleeding.
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| 2. |
- Tang, Ting-Ting, et al.
(författare)
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Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure.
- 2011
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203 .- 1932-6203. ; 6:9, s. e24272-
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Tidskriftsartikel (refereegranskat)abstract
- Animal studies suggest that regulatory T (T(reg)) cells play a beneficial role in ventricular remodeling and our previous data have demonstrated defects of T(reg) cells in patients with chronic heart failure (CHF). However, the mechanisms behind T(reg-)cell defects remained unknown. We here sought to elucidate the mechanism of T(reg-)cell defects in CHF patients.
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| 3. |
- Zhang, Kai Xin, et al.
(författare)
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Substrate-thickness dependence of negative-index metamaterials at optical frequencies
- 2024
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Ingår i: Applied Physics Letters. - 0003-6951 .- 1077-3118. ; 124:10
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Tidskriftsartikel (refereegranskat)abstract
- Optical metamaterials have attracted intensive attention in recent years for their broad applications in superlenses, electromagnetic cloaking, and bio-sensing. Negative refractive index (NRI) metal-dielectric-metal fishnet metamaterials (MMs) are typically used for beyond-diffraction-limit imaging. However, there are few reports about the substrate-thickness dependence of NRI, which strongly affects the practical application. In our study, it is demonstrated that the membrane-based NRI MMs with a more negative index work better than the bulk substrate-based counterparts. In addition, a regular periodic vibration of NRI with the thickness of the membrane substrate was theoretically studied. The destructive interference of the thin film can explain this phenomenon. Furthermore, the proposed explanation was further proved by substituting the dielectric spacer with a larger permittivity. Therefore, an NRI structure on a membrane substrate with constructive interference can be a good choice in ultra-compact photoelectronic devices. This study can be a guide to the practical application of ultracompact NRI devices.
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