| 1. |
- Allentoft, Morten E., et al.
(författare)
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100 ancient genomes show repeated population turnovers in Neolithic Denmark
- 2024
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 625, s. 329-337
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Tidskriftsartikel (refereegranskat)abstract
- Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales1–4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5–7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet (13C and 15N content), mobility (87Sr/86Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transition was delayed by more than a millennium relative to Central Europe, it was very abrupt and resulted in a population turnover with limited genetic contribution from local hunter-gatherers. The succeeding Neolithic population, associated with the Funnel Beaker culture, persisted for only about 1,000 years before immigrants with eastern Steppe-derived ancestry arrived. This second and equally rapid population replacement gave rise to the Single Grave culture with an ancestry profile more similar to present-day Danes. In our multiproxy dataset, these major demographic events are manifested as parallel shifts in genotype, phenotype, diet and land use.
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| 2. |
- Allentoft, Morten E., et al.
(författare)
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Population genomics of post-glacial western Eurasia
- 2024
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 625:7994, s. 301-311
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Tidskriftsartikel (refereegranskat)abstract
- Western Eurasia witnessed several large-scale human migrations during the Holocene1–5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 bp, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 bp, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
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| 3. |
- Als, Per, et al.
(författare)
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Hvordan får vi mere og bedre kollektiv trafik för pengene? : Bud på fremtidens organisering af den kollektive trafik i Greater Copenhagen
- 2017
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Rapport (populärvet., debatt m.m.)abstract
- Region Hovedstaden har i sin regionale vækst- og udviklingsstrategi (ReVUS) sat nogle strategiske rammer for en grøn og innovativ metropol med høj vækst og livskvalitet. Et af de strategiske pejlemærker handler om ’Effektiv og bæredygtig mobilitet’.Hovedstadsområdet har i dag store trafikale udfordringer med kø på vejene samt trængsel i busser og tog. Udfordringerne vil kun vokse i de kommende år, hvor indbyg-gertallet forventes at stige med over 200.000. Der er behov for en sammenhængende planlægning, som kan medvirke til at reducere trængslen og dermed understøtte den økonomiske vækst og udvikling.Region Hovedstaden har taget initiativ til et arbejde, der skal skabe større sammenhæng i den kollektive trafik i den danske del af Greater Copenhagen. Hvis den kollektive trafik skal løfte en større del af trængselsudfordringen,skal der arbejdes på at udbygge kapaciteten, forbedre servicen og sikre en større sammenhæng på tværs af transportformerne. Køer på motorveje og trængsel i den kollektive transport er dyrt for samfundet.Til at understøtte arbejdet har Region Hovedstaden nedsat en ekspertgruppe, der med faglige briller kommer med sit bud på, hvilke udfordringer den kollektive trafik skal kunne imødekomme. Oplægget tager udgangspunkt i paraplyorganisationen Din Offentlige Transport (DOT), og hensigten er:at påpege styrker og svagheder i den nuværende organisationat komme med bud på, hvordan man inden for den nu-værende lovgivning kan imødegå nogle af den kollek-tive trafiks udfordringerat komme med bud på, hvordan man med en ændret lovgivning yderligere kan forbedre den kollektive trafiks sammenhæng og attraktivitetGruppen har ikke gennemført en ny, selvstændig analyse. Arbejdet bygger på eksisterende analyser og på den viden og erfaring, som gruppens medlemmer besidder.
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| 4. |
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| 5. |
- De Cock, Roosmarijn F W, et al.
(författare)
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A Neonatal Amikacin Covariate Model Can Be Used to Predict Ontogeny of Other Drugs Eliminated Through Glomerular Filtration in Neonates
- 2014
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Ingår i: Pharmaceutical research. - : Springer Science and Business Media LLC. - 0724-8741 .- 1573-904X. ; 31:3, s. 754-767
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSERecently, a covariate model characterizing developmental changes in clearance of amikacin in neonates has been developed using birth bodyweight and postnatal age. The aim of this study was to evaluate whether this covariate model can be used to predict maturation in clearance of other renally excreted drugs.METHODSFive different neonatal datasets were available on netilmicin, vancomycin, tobramycin and gentamicin. The extensively validated covariate model for amikacin clearance was used to predict clearance of these drugs. In addition, independent reference models were developed based on a systematic covariate analysis.RESULTSThe descriptive and predictive properties of the models developed using the amikacin covariate model were good, and fairly similar to the independent reference models (goodness-of-fit plots, NPDE). Moreover, similar clearance values were obtained for both approaches. Finally, the same covariates as in the covariate model of amikacin, i.e. birth bodyweight and postnatal age, were identified on clearance in the independent reference models.CONCLUSIONSThis study shows that pediatric covariate models may contain physiological information since information derived from one drug can be used to describe other drugs. This semi-physiological approach may be used to optimize sparse data analysis and to derive individualized dosing algorithms for drugs in children.
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| 6. |
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| 7. |
- Dinér, Peter, et al.
(författare)
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Enantioselective hydroxylation of nitroalkenes : an organocatalytic approach
- 2007
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Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; :35, s. 3646-3648
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Tidskriftsartikel (refereegranskat)abstract
- An easy hydroxylation of aliphatic nitroalkenes in high yields and enantioselectivities is catalysed by bifunctional thiourea-cinchona alkaloids giving access to optically active nitroalcohols and aminoalcohols as final products.
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| 8. |
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| 9. |
- Eltved, Morten, et al.
(författare)
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Impacts of long-term service disruptions on passenger travel behaviour: A smart card analysis from the Greater Copenhagen area
- 2021
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Ingår i: Transportation Research Part C. - : Elsevier. - 0968-090X .- 1879-2359. ; 131
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Tidskriftsartikel (refereegranskat)abstract
- Disruptions in public transport are a major source of frustration for passengers and result in lower public transport usage. Previous studies on the effect of disruptions on passenger travel behaviour have mainly focused on shorter disruptions, while the few studies on impacts of long-term disruptions have had limited focus on individual passenger behaviour. This paper fills the gap in research by proposing a novel methodology based on smart card data for analysing the impacts of long-term planned disruptions on passenger travel behaviour. We use k-means clustering to group passengers based on their travel behaviour before and after the closure. We can thus observe how different passenger groups changed travel behaviour after the disruption. We compare these observations to a group of reference lines without disruption to account for general trends. Using hierarchical clustering of daily travel patterns, we are able to in-depth analyse the reactions of certain passenger groups to the disruption. We apply the method on a 3-month closure of a rail line in the Greater Copenhagen area. The results suggest that, in particular, passengers with an everyday commuting behaviour have decreased after the disruption. The proposed methodology enables explicit analysis of the impact of disruptions on diverse passengers segments, while the specific results are useful for public transport agencies when planning long-term maintenance projects.
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