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- Falkmer, Torbjörn, et al.
(författare)
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Teaching learner drivers with disabilities : An operation manual for driving instructors
- 2000
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The present manual is one of the outcomes of an EU-project with the title ODIGO. It was carried out within the Horizon initiative. As part of the ODIGO/HORIZON project Körkort Handikapp, Lernia in Kävlinge (formerly AmuGruppen, Kävlinge) in Sweden were requested to produce an operation manual for driving instructors, to be used in driver education for persons with special needs (PSN).The present manual is aiming at providing knowledge about PSN and to support driving instructors that educate PSN. In the introduction of the manual, the require-ments demanded of a driving school facility and some general aspects of teaching are considered. In the following driver education exercises are presented. In those, references to Appendix 1 are inserted, in which specific aspects of the driver education with respect to PSN are discussed. This appendix also includes an introduction to the area of education and PSN. In addition, a section called “Disabilities and vehicle adaptation” is enclosed, in order to provide an orientation within the field of PSN and vehicle adaptation. In the last section a suggestion for a lay out of logbook sheets for driver education is enclosed.
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| 3. |
- Kehler, Jan, et al.
(författare)
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Discovery and Development of C-11-Lu AE92686 as a Radioligand for PET Imaging of Phosphodiesterase10A in the Brain
- 2014
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Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 55:9, s. 1513-1518
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Tidskriftsartikel (refereegranskat)abstract
- Phosphodiesterase 10A (PDE10A) plays a key role in the regulation of brain striatal signaling, and several pharmaceutical companies currently investigate PDE10A inhibitors in clinical trials for various central nervous system diseases. A PDE10A PET ligand may provide evidence that a clinical drug candidate reaches and binds to the target. Here we describe the successful discovery and initial validation of the novel radiolabeled PDE10A ligand 5,8-dimethyl-2-[2-((1-C-11-methyl)-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine (C-11-Lu AE92686) and its tritiated analog H-3-Lu AE92686. Methods: Initial in vitro experiments suggested Lu AE92686 as a promising radioligand, and the corresponding tritiated and C-11-labeled compounds were synthesized. 3H-Lu AE92686 was evaluated as a ligand for in vivo occupancy studies in mice and rats, and C-11-Lu AE92686 was evaluated as a PET tracer candidate in cynomolgus monkeys and in humans. Results: C-11-Lu AE92686 displayed high specificity and selectivity for PDE10A-expressing regions in the brain of cynomolgus monkeys and humans. Similar results were found in rodents using 3H-Lu AE92686. The binding of C-11-Lu AE92686 and 3H-Lu AE92686 to striatum was completely and dose-dependently blocked by the structurally different PDE10A inhibitor 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (MP-10) in rodents and in monkeys. In all species, specific binding of the radioligand was seen in the striatum but not in the cerebellum, supporting the use of the cerebellum as a reference region. The binding potentials (BPND) of C-11-Lu AE92686 in the striatum of both cynomolgus monkeys and humans were evaluated by the simplified reference tissue model with the cerebellum as the reference tissue, and BPND was found to be high and reproducible-that is, BP(ND)s were 6.5 +/- 0.3 (n = 3) and 7.5 +/- 1.0 (n = 12) in monkeys and humans, respectively. Conclusion: Rodent, monkey, and human tests of labeled Lu AE92686 suggest that C-11-Lu AE92686 has great potential as a human PET tracer for the PDE10A enzyme.
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| 4. |
- Levin, Lena, 1958-, et al.
(författare)
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Äldre i transportsystemet : mobilitet, design och träningsproblematik
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Generally, more elderly will be travelling and be out on the roads as active road-users in the future. Research exists on the travelling habits of the elderly; but more in-depth knowledge on the elderly's preferences as license-holders, drivers, road-users and actors in public transport is required. The aim of this report is to give an overview of previous research as well as to indicate a number of directions for future research on the mobility of the elderly as actors within the transport system. The work has a clear multidisciplinary approach, with knowledge from social science, behavioural science and technical research on transport and the elderly. However, the main weight lays on social science and behavioural science issues. The report is divided into eleven chapters: 1) contains a short background, purpose and method questions; 2) discusses the project's scientific and social relevance; 3) provides theoretical background and theoretical concepts; 4) mentions previous research on the elderly as car drivers; 5) is a chapter on license-less vehicles; 6) discusses traffic and road design for the elderly; 7) discusses the elderly as pedestrians and bicycle road-users; 8) is about the elderly in public transport and 9) is about the training of elderly drivers. Chapter 10) consists of a final discussion and chapter 11) summarises point by point the need for research on issues which have come to light in the report
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- Nielsen, Per Rotbøll, et al.
(författare)
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Prehabilitation and early rehabilitation after spinal surgery: randomized clinical trial
- 2010
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Ingår i: Clinical Rehabilitation. - : SAGE Publications. - 0269-2155 .- 1477-0873. ; 24:2, s. 137-148
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To evaluate the outcome after spinal surgery when adding prehabilitation to the early rehabilitation.Design: A randomized clinical study.Setting: Orthopaedic surgery department.Subject: Sixty patients scheduled for surgery followed by inpatient rehabilitation for degenerative lumbar disease.Interventions: The patients were computer randomized to prehabilitation and early rehabilitation (28 patients) or to standard care exclusively (32 patients). The intervention began two months prior to the operation. The prehabilitation included an intensive exercise programme and optimization of the analgesic treatment. Protein drinks were given the day before surgery. The early postoperative rehabilitation included balanced pain therapy with self-administered epidural analgesia, doubled intensified mobilization and protein supplements.Main measures: The outcome measurements were postoperative stay, complications, functionality, pain and satisfaction.Results: At operation the intervention group had improved function, assessed by Roland Morris Questionnaire (P = 0.001). After surgery the intervention group reached the recovery milestones faster than the control group (1—6 days versus 3—13, P =0.001), and left hospital earlier (5 (3—9) versus 7 (5—15) days, P =0.007). There was no difference in postoperative complications, adverse events, low back pain and radiating pain, timed up and go, sit-to-stand or in life quality. Patient satisfaction was significantly higher in the intervention group compared with the control group.Conclusion: The integrated programme of prehabilitation and early rehabilitation improved the outcome and shortened the hospital stay — without more complications, pain or dissatisfaction.
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