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Träfflista för sökning "WFRF:(Nielsen Sven) "

Sökning: WFRF:(Nielsen Sven)

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Numrering	Referens	Omslagsbild	Hitta
1.	Groen, Solveig Skovlund, et al. (författare) A serological type II collagen neoepitope biomarker reflects cartilage breakdown in patients with osteoarthritis 2021 Ingår i: Osteoarthritis and Cartilage Open. - : Elsevier BV. - 2665-9131. ; 3:4 Tidskriftsartikel (refereegranskat)abstract Objectives: There is an unmet medical need for biomarkers in OA which can be applied in clinical drug development trials. The present study describes the development of a specific and robust assay measuring type II collagen degradation (T2CM) and discusses its potential as a noninvasive translational biomarker. Methods: A type II collagen specific neoepitope (T2CM) was identified by mass spectrometry and monoclonal antibodies were raised towards the epitope, employed in a chemiluminescence immunoassay. T2CM was assessed in bovine cartilage explants with or without MMP-13 inhibitor, and explant supernatants were analyzed by Western blot. T2CM was measured in plasma samples from one study (n = 48 patients) where OA patients were referred to total knee replacement (TKR). Additionally, T2CM was quantified in serum from OA patients receiving salmon calcitonin treatment (sCT) (n = 50) compared to placebo (n = 57). Results: The T2CM assay was technically robust (13/4 % inter/intra-variation) and specific for the type II collagen fragment cleaved by MMP-1 and -13. The MMP-13 inhibitor reduced the T2CM release from bovine cartilage explants receiving catabolic treatment. These results were confirmed by Western blot. In human end-stage OA patients (scheduled for TKR), the T2CM levels were elevated compared to moderate OA (p<0.004). The OA patients receiving sCT had lower levels of T2CM compared to placebo group after 1, 6, and 24 months of treatment (p = 0.0285, p = 0.0484, p = 0.0035). Conclusions: To our knowledge, T2CM is the first technically robust serological biomarker assay which has shown biological relevance in ex vivo models and OA cohorts. This suggests that T2CM may have potential as a translational biomarker for cartilage degradation.
2.	Kehoe, Laura, et al. (författare) Make EU trade with Brazil sustainable 2019 Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
3.	Larsen, A. Nylandsted, et al. (författare) E center in silicon has a donor level in the band gap 2006 Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:10, s. 106402/1-106402/4 Tidskriftsartikel (refereegranskat)abstract It has been an accepted fact for more than 40 years that the E center in Si (the group-V impurity-vacancy pair)-one of the most studied defects in semiconductors-has only one energy level in the band gap: namely, the acceptor level at about 0.45 eV below the conduction band. We now demonstrate that it has a second level, situated in the lower half of the band gap at 0.27 eV above the valence band. The existence of this level, having a donor character, is disclosed by a combination of different transient-capacitance techniques and electronic-structure calculations. The finding seriously questions some diffusion-modeling approaches performed in the past.
4.	Möller, Bernd, et al. (författare) Peta : the Pan-European Thermal Atlas : version 5.2 : developed as part of the sEEnergies project 2022 Annan publikation (karta/atlas) (övrigt vetenskapligt/konstnärligt)abstract The Pan-European Thermal Atlas version 5.2 (Peta, version 5.2). Peta is an online visualization tool for spatial data relating to energy efficiency in buildings, industry, and transport sectors. Developed as part of the sEEnergies project. Copyright Flensburg, Halmstad and Aalborg Universities 2022.
5.	Nielsen, B. Bach, et al. (författare) Local vibrational modes of weakly bound O-H complexes in SI 1997 Ingår i: Defects in semiconductors. - : Trans Tech Publications Inc.. ; , s. 391-398 Konferensbidrag (refereegranskat)abstract Local vibrational modes of two oxygen-hydrogen complexes have been identified with infrared absorption spectroscopy. Samples of intrinsic silicon and samples doped with 16O or 18O isotopes were implanted with protons and deuterons at ∼20 K. After the implantation, infrared absorbance spectra were measured at 8 K on unannealed samples. An oxygen mode at 1077 cm-1 and a hydrogen mode at 1879 cm-1, which originate from the same defect OHI were observed in the as-implanted samples. Heat-treatment at 200 K produced a new center OHII with modes at 1028 and 1830 cm-1. OHI anneals out at ∼130 K while OHII is stable up to ∼240 K. OHI and OHII are tentatively identified with two complexes of interstitial oxygen and bond-centred hydrogen. Ab initio theory was applied to calculate the structure and local modes of three such complexes. The results qualitatively support our tentative assignments.
6.	Aad, G., et al. (författare) A search for prompt lepton-jets in pp collisions at root s=7 TeV with the ATLAS detector 2013 Tidskriftsartikel (refereegranskat)
7.	Aad, G., et al. (författare) ATLAS measurements of the properties of jets for boosted particle searches 2012 Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 86:7 Tidskriftsartikel (refereegranskat)
8.	Aad, G., et al. (författare) Combined search for the Standard Model Higgs boson in pp collisions at root s=7 TeV with the ATLAS detector 2012 Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 86:3 Tidskriftsartikel (refereegranskat)
9.	Aad, G., et al. (författare) Drift Time Measurement in the ATLAS Liquid Argon Electromagnetic Calorimeter using Cosmic Muons 2010 Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 755-785 Tidskriftsartikel (refereegranskat)
10.	Aad, G., et al. (författare) Evidence for the associated production of a W boson and a top quark in ATLAS at root s=7 TeV 2012 Tidskriftsartikel (refereegranskat)

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