| 1. |
- Englund, Hans, 1971-, et al.
(författare)
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Learning-Environment Uncertainty and Students' Approaches to Learning : A Self-Determination Theory Perspective
- 2023
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Ingår i: Scandinavian Journal of Educational Research. - : Routledge. - 0031-3831 .- 1470-1170. ; 67:4, s. 559-573
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Tidskriftsartikel (refereegranskat)abstract
- In the literature on the relationship between learning environments and students' approaches to learning, much attention has been directed to aspects that foster a deep approach. Considerably less attention has been directed to aspects that result in the opposite, namely a surface approach. Indeed, there is a small literature focusing on how learning environments can frustrate the basic psychological needs of individuals and, as a result, foster a surface approach. However, hitherto, this stream has focused on controlling elements in learning environments. We add to this latter literature, through focusing on learning-environment uncertainty. This notion emerged from a qualitative study of 19 students at a Swedish university, where we identified three types of learning-environment uncertainty, related to the basic psychological needs for autonomy, competence, and relatedness. The findings suggest that a surface approach to learning can be understood as a coping strategy that students adopt to reduce such uncertainties.
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| 2. |
- Sundström, Johan, Professor, 1971-, et al.
(författare)
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Rationale for a Swedish cohort consortium
- 2019
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Ingår i: Upsala Journal of Medical Sciences. - : Taylor & Francis Group. - 0300-9734 .- 2000-1967. ; 124:1, s. 21-28
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Tidskriftsartikel (refereegranskat)abstract
- We herein outline the rationale for a Swedish cohort consortium, aiming to facilitate greater use of Swedish cohorts for world-class research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure would enable more precise research findings and facilitate research on rare exposures and outcomes, leading to better utilization of study participants' data, better return of funders' investments, and higher benefit to patients and populations. We motivate the proposed infrastructure partly by lessons learned from a pilot study encompassing data from 21 cohorts. We envisage a standing Swedish cohort consortium that would drive development of epidemiological research methods and strengthen the Swedish as well as international epidemiological competence, community, and competitiveness.
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| 3. |
- Sundström, Johan, Professor, 1971-, et al.
(författare)
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Risk factors for subarachnoid haemorrhage : a nationwide cohort of 950 000 adults
- 2019
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Ingår i: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 48:6, s. 2018-2025
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Subarachnoid haemorrhage (SAH) is a devastating disease, with high mortality rate and substantial disability among survivors. Its causes are poorly understood. We aimed to investigate risk factors for SAH using a novel nationwide cohort consortium.METHODS: We obtained individual participant data of 949 683 persons (330 334 women) between 25 and 90 years old, with no history of SAH at baseline, from 21 population-based cohorts. Outcomes were obtained from the Swedish Patient and Causes of Death Registries.RESULTS: During 13 704 959 person-years of follow-up, 2659 cases of first-ever fatal or non-fatal SAH occurred, with an age-standardized incidence rate of 9.0 [95% confidence interval (CI) (7.4-10.6)/100 000 person-years] in men and 13.8 [(11.4-16.2)/100 000 person-years] in women. The incidence rate increased exponentially with higher age. In multivariable-adjusted Poisson models, marked sex interactions for current smoking and body mass index (BMI) were observed. Current smoking conferred a rate ratio (RR) of 2.24 (95% CI 1.95-2.57) in women and 1.62 (1.47-1.79) in men. One standard deviation higher BMI was associated with an RR of 0.86 (0.81-0.92) in women and 1.02 (0.96-1.08) in men. Higher blood pressure and lower education level were also associated with higher risk of SAH.CONCLUSIONS: The risk of SAH is 45% higher in women than in men, with substantial sex differences in risk factor strengths. In particular, a markedly stronger adverse effect of smoking in women may motivate targeted public health initiatives.
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| 4. |
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| 5. |
- Angerås, Oskar, 1976, et al.
(författare)
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Impact of Thrombus Aspiration on Mortality, Stent Thrombosis, and Stroke in Patients with ST-Segment-Elevation Myocardial Infarction: A Report From the Swedish Coronary Angiography and Angioplasty Registry
- 2018
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Ingår i: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Background-Thrombus aspiration is still being used in a substantial number of patients despite 2 large randomized clinical trials showing no favorable effect of routine thrombus aspiration during primary percutaneous coronary intervention in patients with STsegment- elevation myocardial infarction. The aim of this observational study was to evaluate the impact of thrombus aspiration on mortality, stent thrombosis, and stroke using all available data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR). Methods and Results--We identified 42 829 consecutive patients registered in SCAAR between January 2005 and September 2014 who underwent percutaneous coronary intervention for ST-segment-elevation myocardial infarction. Thrombus aspiration was used in 25% of the procedures. We used instrumental variable analysis with administrative healthcare region as the treatmentpreference instrumental variable to evaluate the effect of thrombus aspiration on mortality, stent thrombosis, and stroke. Thrombus aspiration was not associated with mortality at 30 days (risk reduction: -1.2; 95% confidence interval [CI] , -5.4 to 3.0; P=0.57) and 1 year (risk reduction: -2.4; 95% CI, -7.6 to 3.0; P=0.37). Thrombus aspiration was associated with a lower risk of stent thrombosis both at 30 days (risk reduction: -2.7; 95% CI, -4.1 to -1.4; P < 0.001) and 1 year (risk reduction: -3.5; 95% CI, -5.3 to -1.7; P < 0.001). In-hospital stroke and neurologic complications did not differ between groups (risk reduction: 0.1; 95% CI, -0.8 to 1.1; P=0.76). Conclusions--Mortality was not different between the groups. Thrombus aspiration was associated with decreased risk of stent thrombosis. Our study provides important evidence for the external validity of previous randomized studies regarding mortality.
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| 6. |
- Axelsson, Josefine, 1992-
(författare)
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Interglacial climates in proxies and models : Utilizing sampled oxygen isotopes and model simulations to understand past Indian summer monsoon variability
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The study of Earth's climate system, including the mechanisms driving monsoon systems, is a key area of research within environmental sciences. Monsoons, vital for billions of people, are complex atmospheric phenomena influenced by various global factors, including orbital changes and natural climate variability. Among monsoon systems, the Indian summer Monsoon (ISM) is of particular interest due to its significant impact on the South Asian climate, agriculture, and water resources. Despite extensive study, comprehending the ISM's historical variability and its future implications remains a challenge. Utilizing natural archives like speleothems, along with stable water isotopes from precipitation and advanced climate model simulations, this thesis aims to decipher the ISM's responses to natural forcings across key interglacial periods—the Last Interglacial and the Holocene.Our findings indicate that the ISM's strength is critically influenced by slight variations in orbital configurations, leading to significant shifts in monsoon patterns. Our research also highlights the dual influence of local geographical features and distant atmospheric conditions on the ISM's annual variability. Most notably, we observed discrepancies between δ18O values obtained from isotope-enabled climate models and those derived from speleothems. This insight indicates that the models need refinement to accurately mirror the complexities observed in the proxy records and that the uncertainty parameter in speleothem records needs to be improved.The alignment between proxy and model data is crucial for a more accurate reconstruction of past climates and for enhancing the predictive capabilities of future monsoon behavior under changing climatic conditions. By advancing our knowledge of the ISM's past, we are better equipped to anticipate its future. To achieve that, this thesis stresses the importance of bridging the gap between proxy data insights and climate model simulations. This would not only enrich our historical climate knowledge but also inform future climate projections, highlighting the indispensable role of interdisciplinary research in climate science challenges.
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| 7. |
- Bergquist, Annika, et al.
(författare)
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Impact on follow-up strategies in patients with primary sclerosing cholangitis
- 2023
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Ingår i: Liver international (Print). - Chichester, United Kingdom : Wiley-Blackwell Publishing Inc.. - 1478-3223 .- 1478-3231. ; 43:1, s. 127-138
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Evidence for the benefit of scheduled imaging for early detection of hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow-up strategies in PSC with the hypothesis that regular imaging improves survival.METHODS: We collected retrospective data from 2,975 PSC patients from 27 centers. Patients were followed from the start of scheduled imaging or in case of clinical follow-up from January 1, 2000, until death or last clinical follow-up alive. The primary endpoint was all-cause mortality.RESULTS: A broad variety of different follow-up strategies were reported. All except one center used regular imaging, ultrasound (US) and/or magnetic resonance imaging (MRI). Two centers used scheduled ERCP in addition to imaging for surveillance purposes. The overall HR (CI95%) for death, adjusted for sex, age and start year of follow-up, were 0.61 (0.47-0.80) for scheduled imaging with and without ERCP; 0.64 (0.48-0.86) for US/MRI and 0.53 (0.37-0.75) for follow-up strategies including scheduled ERCP. The lower risk of death remained for scheduled imaging with and without ERCP after adjustment for cholangiocarcinoma (CCA) or high-grade dysplasia as a time-dependent covariate, HR 0.57 (0.44-0.75). Hepatobiliary malignancy was diagnosed in 175 (5.9%) of the patients at 7.9 years follow-up. Asymptomatic patients (25%) with CCA had better survival if scheduled imaging had been performed.CONCLUSIONS: Follow-up strategies vary considerably across centers. Scheduled imaging was associated with improved survival. Multiple factors may contribute to this result including early tumor detection and increased endoscopic treatment of asymptomatic benign biliary strictures.
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| 8. |
- Blomberg, Jeanette, 1977-, et al.
(författare)
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Reduced FAS transcription in clones of U937 cells that have acquired resistance to Fas-induced apoptosis
- 2009
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Ingår i: The FEBS Journal. - : Wiley. - 1742-464X .- 1742-4658. ; 276:2, s. 497-508
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Tidskriftsartikel (refereegranskat)abstract
- Susceptibility to cell death is a prerequisite for the elimination of tumour cells by cytotoxic immune cells, chemotherapy or irradiation. Activation of the death receptor Fas is critical for the regulation of immune cell homeostasis and efficient killing of tumour cells by apoptosis. To define the molecular changes that occur during selection for insensitivity to Fas-induced apoptosis, a resistant variant of the U937 cell line was established. Individual resistant clones were isolated and characterized. The most frequently observed defect in the resistant cells was reduced Fas expression, which correlated with decreased FAS transcription. Clones with such reduced Fas expression also displayed partial cross-resistance to tumour necrosis factor-alpha stimulation, but the mRNA expression of tumour necrosis factor receptors was not decreased. Reintroduction of Fas conferred susceptibility to Fas but not to tumour necrosis factor-alpha stimulation, suggesting that several alterations could be present in the clones. The reduced Fas expression could not be explained by mutations in the FAS coding sequence or promoter region, or by silencing through methylations. Protein kinase B and extracellular signal-regulated kinase, components of signalling pathways downstream of Ras, were shown to be activated in some of the resistant clones, but none of the three RAS genes was mutated, and experiments using chemical inhibitors could not establish that the activation of these proteins was the cause of Fas resistance as described in other systems. Taken together, the data illustrate that Fas resistance can be caused by reduced Fas expression, which is a result of an unidentified mode of regulation.
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| 9. |
- Blomquist, Tomas, et al.
(författare)
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Development of Virtual Teams and Learning Communities
- 2005
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Ingår i: Recent Research Developments in Learning Technologies. - Badajos, Spain : Formatex Research Center. ; , s. 1184-1189
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Konferensbidrag (refereegranskat)abstract
- Students of an Internet based course in project management worked during a 20 week period in teams of 4-6 persons. The course consisted of Swedish students living in Sweden or abroad which made it impossible for many of the teams to have any face-to-face interaction. During the course the teams were assigned to a series of discussion questions and cases. The study, based on a survey of 287 students who participated in the course, examined their experience of teamwork and showed that many of the classical team development issues also evolve in a virtual team. Furthermore, the study showed that students considered their teamwork was efficient and that being able to communicate, discuss and share experiences was essential for developing a positive learning community.
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| 10. |
- Blomquist, Tomas, et al.
(författare)
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Development of virtual teams and learning communities
- 2006
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Ingår i: Collaborating virtually. - Punjagutta, India : Icfai University Press. - 8131403084 ; , s. 121-131
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Bokkapitel (refereegranskat)abstract
- Students of an Internet based course in project management worked during a 20 week period worked in teams of 4-6 persons. The course consisted of Swedish students living in Sweden or abroad, which made it impossible for many of the teams to have any face-to-face interaction. During the course, the teams were assigned a series of discussion questions and cases. The study, based on a survey of 287 students who participated in the course, examined their experience of teamwork and showed that many of the classical team development issues also evolve in a virtual team. Furthermore, the study showed that students considered their teamwork was efficient and that being able to communicate, discuss and share experiences was essential for developing a positive learning community.
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