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- 2019
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Culina, Antica, et al.
(författare)
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Connecting the data landscape of long-term ecological studies : The SPI-Birds data hub
- 2021
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Ingår i: Journal of Animal Ecology. - : John Wiley & Sons. - 0021-8790 .- 1365-2656. ; 90:9, s. 2147-2160
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Tidskriftsartikel (refereegranskat)abstract
- The integration and synthesis of the data in different areas of science is drastically slowed and hindered by a lack of standards and networking programmes. Long-term studies of individually marked animals are not an exception. These studies are especially important as instrumental for understanding evolutionary and ecological processes in the wild. Furthermore, their number and global distribution provides a unique opportunity to assess the generality of patterns and to address broad-scale global issues (e.g. climate change). To solve data integration issues and enable a new scale of ecological and evolutionary research based on long-term studies of birds, we have created the SPI-Birds Network and Database ()-a large-scale initiative that connects data from, and researchers working on, studies of wild populations of individually recognizable (usually ringed) birds. Within year and a half since the establishment, SPI-Birds has recruited over 120 members, and currently hosts data on almost 1.5 million individual birds collected in 80 populations over 2,000 cumulative years, and counting. SPI-Birds acts as a data hub and a catalogue of studied populations. It prevents data loss, secures easy data finding, use and integration and thus facilitates collaboration and synthesis. We provide community-derived data and meta-data standards and improve data integrity guided by the principles of Findable, Accessible, Interoperable and Reusable (FAIR), and aligned with the existing metadata languages (e.g. ecological meta-data language). The encouraging community involvement stems from SPI-Bird's decentralized approach: research groups retain full control over data use and their way of data management, while SPI-Birds creates tailored pipelines to convert each unique data format into a standard format. We outline the lessons learned, so that other communities (e.g. those working on other taxa) can adapt our successful model. Creating community-specific hubs (such as ours, COMADRE for animal demography, etc.) will aid much-needed large-scale ecological data integration.
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| 4. |
- Marklund, Göran T., et al.
(författare)
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Cluster multipoint study of the acceleration potential pattern and electrodynamics of an auroral surge and its associated horn arc
- 2012
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117:10, s. A10223-
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Tidskriftsartikel (refereegranskat)abstract
- Cluster results are presented from the acceleration region of an auroral surge and connected horn arc, observed during an extended time period of substorm activity. The Cluster spacecraft crossed different magnetic local time (MLT) sectors of the surge and horn, with lag times of 2-10 min. Acceleration potential patterns are derived for the horn arc and for the double arc (surge and horn) at the surge front and deeper into the surge. The parallel potential drop of the horn arc ranged between 4 and 7 kV. At the surge front, two weakly coupled U-potentials with parallel potential drops of 8 (7) kV and 7 (5) kV were derived for the surge and horn, respectively, from the C3 (C4) data. A similar, more coupled pattern was derived for the region deeper into the surge. We also address how the field-aligned currents of the surge and horn system close in the ionosphere. The Cluster data allow almost simultaneous estimates of the latitudinal current closure at various MLT sectors. Significant net upward currents are derived for the horn and surge, whereas the currents at the surge front were found to be balanced. The net upward horn current is proposed to be fed by the zonal divergence of the westward Pedersen current in the horn, consistent with the acceleration potential decrease in the westward horn direction. The net upward surge current is proposed to be fed by the divergence of a westward electrojet and by localized downward currents adjacent to the surge.
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| 5. |
- Marklund, Göran T., et al.
(författare)
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Evolution in space and time of the quasi-static acceleration potential of inverted-V aurora and its interaction with Alfvenic boundary processes
- 2011
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 116, s. A00K13-
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Tidskriftsartikel (refereegranskat)abstract
- Results are presented from Cluster crossings of the acceleration region of two inverted-V auroras located in the poleward part of an extensive substorm bulge. The particle and field data are used to infer the acceleration potentials of the arcs and their distribution in altitude and latitude. The C1 data are consistent with a symmetric potential pattern, composed of two negative U potentials and one positive U potential in between, and the C3 and C4 data are consistent with an asymmetric pattern, where the dominating potential structure extends deep into the polar cap boundary (PCB) region. The two patterns may either correspond to different stages of evolution of the same double arc system or represent two longitudinally separated double arc systems. For all spacecraft, the potential well of the poleward arc extends into the PCB region, whereas the density cavity does not but remains confined to R1. This suggests that the Alfvenic activity observed within the PCB region prevents the cavity formation, consistent with the associated FACs being roughly balanced over this region. The results show that Alfvenic and quasi-static acceleration operates jointly in the PCB region, varying from being about equally important (on C1) to being predominantly quasi-static (on C3/C4). The presence (absence) of an upward electron beam, associated with a positive potential structure and a downward current, observed by C1 (C4/C3) is expected from its short life time, shorter than the time lag between the Cluster spacecraft. The evolution involves both a broadening and a density reduction of the associated downward current sheet to below the critical current density above which parallel electric fields will form. The deepest potential well of 13 kV observed by C4 was located in Region 1, adjacent to the PCB region and coinciding with the deepest density cavity, with a minimum density of 0.1 cm(-3). The interface between Region 1 and the PCB region, coinciding with the steep density gradient, appears to be the leading edge of the cavity.
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| 7. |
- Barbosa, Edna J L, 1961, et al.
(författare)
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Extracellular water and blood pressure in adults with growth hormone (GH) deficiency: a genotype-phenotype association study.
- 2014
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 9:8
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Tidskriftsartikel (refereegranskat)abstract
- Growth hormone deficiency (GHD) in adults is associated with decreased extracellular water volume (ECW). In response to GH replacement therapy (GHRT), ECW increases and blood pressure (BP) reduces or remains unchanged. Our primary aim was to study the association between polymorphisms in genes related to renal tubular function with ECW and BP before and 1 year after GHRT. The ECW measures using bioimpedance analysis (BIA) and bioimpedance spectroscopy (BIS) were validated against a reference method, the sodium bromide dilution method (Br(-)).
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| 8. |
- Barbosa, Edna J L, 1961, et al.
(författare)
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Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.
- 2012
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Ingår i: European journal of endocrinology / European Federation of Endocrine Societies. - 1479-683X .- 0804-4643. ; 167:3, s. 353-62
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Tidskriftsartikel (refereegranskat)abstract
- bjective: GH deficiency (GHD) in adults is associated with an altered serum lipid profile that responds to GH replacement therapy (GHRT). This study evaluated the influence of polymorphisms in genes related to lipid metabolism on serum lipid profile before and after 1 year of GHRT in adults. Design and methods: In 318 GHD patients, total cholesterol (TC) serum concentrations, LDL-C, HDL-C, and triglycerides (TG) were assessed. Using a candidate gene approach, 20 single nucleotide polymorphisms (SNPs) were genotyped. GH dose was individually titrated to obtain normal serum IGF1 concentrations. Results: At baseline, the minor alleles of cholesteryl ester transfer protein (CETP) gene SNPs rs708272 and rs1800775 were associated with higher serum TC and apolipoprotein E (APOE) gene SNP rs7412 with lower TC concentrations; CETP SNPs rs708272, rs1800775, and rs3764261 and apolipoprotein B (APOB) gene SNP rs693 with higher serum HDL-C; APOE SNP rs7412, peroxisome proliferator-activated receptor gamma (PPARG) gene SNP rs10865710 with lower LDL-C, and CETP SNP rs1800775 with higher LDL-C; and APOE/C1/C4/C2 cluster SNP rs35136575 with lower serum TG. After treatment, APOB SNP rs676210 GG genotype was associated with larger reductions in TC and LDL-C and PPARG SNP rs10865710 CC genotype with greater TC reduction. All associations remained significant when adjusted for age, sex, and BMI. Conclusions: In GHD adults, multiple SNPs in genes related to lipid metabolism contributed to individual differences in baseline serum lipid profile. The GH treatment response in TC and LDL-C was influenced by polymorphisms in the APOB and PPARG genes.
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| 9. |
- Ellis, Vincenzo A., et al.
(författare)
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Explaining prevalence, diversity and host specificity in a community of avian haemosporidian parasites
- 2020
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Ingår i: Oikos. - : Wiley. - 0030-1299 .- 1600-0706. ; 129:9, s. 1314-1329
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Tidskriftsartikel (refereegranskat)abstract
- Many hypotheses attempt to explain parasite–host associations, but rarely are they examined together in a single community. For hosts, key traits are the proportion of infected individuals (prevalence) and the diversity of parasites infecting them. A key parasite trait is host specificity, ranging from specialists infecting one or a few closely related species to generalists infecting many species. We tested 10 hypotheses to explain host-parasite associations; five ‘host-centric’ (e.g. prevalence is related to host abundance) and five ‘parasite-centric’ (e.g. parasite abundance is related to host specificity). We analyzed a community of 67 locally transmitted avian haemosporidian parasite lineages (genera Plasmodium, Haemoproteus or Leucocytozoon), sampled from 2726 birds (64 species) in southern Sweden. Among host-centric hypotheses, Haemoproteus and Leucocytozoon prevalence and Haemoproteus diversity were related to host habitat preferences, whereas there were no relationships with host abundance or body mass. Haemoproteus and Leucocytozoon prevalences were more similar among closely related than among distantly related host species. Haemoproteus prevalence and diversity were lower in host species with few close relatives (‘evolutionarily distinct’ hosts). Among parasite-centric hypotheses, most lineages, even relative generalists, infected closely related host species more often than expected by chance. However, the host species of Haemoproteus and Leucocytozoon lineages overlapped less among lineages than expected by chance. Specialists did not reach higher prevalences than generalists on single host species. However, the abundance of Haemoproteus lineages was related to host specificity with generalists more common than specialists; this was driven by three closely related generalists. Host specificity of parasites was unrelated to the abundance or evolutionarily distinctiveness of their hosts. Parasite communities are likely structured by many factors and cannot be explained by hypotheses focusing solely on hosts or parasites. However, we found consistent effects of host phylogenetic relationships, plausibly a result of evolutionarily conserved host immune systems limiting parasite distributions.
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| 10. |
- Glad, Camilla A M, 1981, et al.
(författare)
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SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults.
- 2014
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Ingår i: European journal of endocrinology / European Federation of Endocrine Societies. - 1479-683X .- 0804-4643. ; 170:1, s. 101-7
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Tidskriftsartikel (refereegranskat)abstract
- GH-deficient (GHD) adults have reduced serum concentrations of IGF1. GH replacement therapy increases serum IGF1 concentrations, but the interindividual variation in treatment response is large and likely influenced by genetic factors. This study was designed to test the hypothesis that single-nucleotide polymorphisms (SNPs) in genes within the GH signaling pathway influence the serum IGF1 response to GH replacement.
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