| 1. |
- Östensson, Malin, 1984, et al.
(författare)
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A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease
- 2013
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:8
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Tidskriftsartikel (refereegranskat)abstract
- Celiac disease is a common autoimmune disorder characterized by an intestinal inflammation triggered by gluten, a storage protein found in wheat, rye and barley. Similar to other autoimmune diseases such as type 1 diabetes, psoriasis and rheumatoid arthritis, celiac disease is the result of an immune response to self-antigens leading to tissue destruction and production of autoantibodies. Common diseases like celiac disease have a complex pattern of inheritance with inputs from both environmental as well as additive and non-additive genetic factors. In the past few years, Genome Wide Association Studies (GWAS) have been successful in finding genetic risk variants behind many common diseases and traits. To complement and add to the previous findings, we performed a GWAS including 206 trios from 97 nuclear Swedish and Norwegian families affected with celiac disease. By stratifying for HLA-DQ, we identified a new genome-wide significant risk locus covering the DUSP10 gene. To further investigate the associations from the GWAS we performed pathway analyses and two-locus interaction analyses. These analyses showed an over-representation of genes involved in type 2 diabetes and identified a set of candidate mechanisms and genes of which some were selected for mRNA expression analysis using small intestinal biopsies from 98 patients. Several genes were expressed differently in the small intestinal mucosa from patients with celiac autoimmunity compared to intestinal mucosa from control patients. From top-scoring regions we identified susceptibility genes in several categories: 1) polarity and epithelial cell functionality; 2) intestinal smooth muscle; 3) growth and energy homeostasis, including proline and glutamine metabolism; and finally 4) innate and adaptive immune system. These genes and pathways, including specific functions of DUSP10, together reveal a new potential biological mechanism that could influence the genesis of celiac disease, and possibly also other chronic disorders with an inflammatory component.
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| 2. |
- Colding, Johan, 1958-, et al.
(författare)
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Smart Cities for All? Bridging Digital Divides for Socially Sustainable and Inclusive Cities
- 2024
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Ingår i: Smart Cities. - : MDPI. - 2624-6511. ; 7:3, s. 1044-1059
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Tidskriftsartikel (refereegranskat)abstract
- This paper aims to emphasize the need for enhancing inclusivity and accessibility within smart-city societies. It represents the first attempt to apply Amartya Sen’s capability approach by exploring the implications of digital divides for promoting inclusive and climate-friendly cities that prioritize well-being, equity, and societal participation. Sen’s framework recognizes individual variations in converting resources into valuable ‘functionings’, and herein emphasizes the importance of aligning personal, social, and environmental conversion factors for individuals to fully navigate, participate in, and enjoy the benefits provided by smart cities. Adopting the capability approach and employing a cross-disciplinary analysis of the scientific literature, the primary objective is to broaden understanding of how to improve inclusivity and accessibility within smart-city societies, with a specific focus on marginalized community members facing first- and second-level digital divides. This paper underscores the importance of adopting a systemic perspective on climate-smart city navigation and stresses the importance of establishing a unified governing body responsible for monitoring, evaluating, and enhancing smart-city functionality. The paper concludes by summarizing some policy recommendations to boost social inclusion and address climate change in smart cities, such as creating capability-enhancing institutions, safeguarding redundancy in public-choice options, empowering citizens, and leveraging academic knowledge in smart-city policy formulation.
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| 3. |
- Ghanipour, Lana, et al.
(författare)
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Efficacy of hyperthermic intraperitoneal chemotherapy in colorectal cancer : A phase I and III open label randomized controlled registry-based clinical trial protocol
- 2024
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 19:3
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Tidskriftsartikel (refereegranskat)abstract
- Standard treatment for patient with peritoneal metastases from colorectal cancer is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In recent years, the efficacy of oxaliplatin-based HIPEC has been challenged. An intensified HIPEC (oxaliplatin+irinotecan) in combination with early postoperative intraperitoneal chemotherapy (EPIC) has shown increased recurrence-free survival in retrospective studies. The aim of this trial is to develop a new HIPEC/EPIC regimen and evaluate its effect on morbidity, oncological outcome, and quality-of-life (QoL). This study is designed as a combined phase I/III multicenter randomized trial (RCT) of patients with peritoneal metastases from colorectal cancer eligible for CRS-HIPEC. An initial phase I dose escalation study, designed as a 3+3 stepwise escalation, will determine the maximum tolerable dose of 5-Fluorouracil (5-FU) as 1-day EPIC, enrolling a total of 15–30 patients in 5 dose levels. In the phase III efficacy study, patients are randomly assigned intraoperatively to either the standard treatment with oxaliplatin HIPEC (control arm) or oxaliplatin/irinotecan-HIPEC in combination with single dose of 1-day 5-FU EPIC (experimental arm). 5-FU is administered intraoperatively after CRS-HIPEC and closure of the abdomen. The primary endpoint is 12-month recurrence-free survival. Secondary endpoints include 5-year overall survival, 5-year recurrence-free survival (registry based), postoperative complications, and QoL up to 3 years after study treatment. This phase I/III trial aims to identify a more effective treatment of colorectal peritoneal metastases by combination of HIPEC and EPIC.
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| 4. |
- Nilsson, Caroline, 1984-, et al.
(författare)
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Navigating complexity with the four pillars of social sustainability
- 2024
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Ingår i: Sustainable Development. - . : Wiley. - 2160-7540 .- 2160-7559.
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Tidskriftsartikel (refereegranskat)abstract
- The concept of social sustainability has long been a subject of discussion within academic literature and practitioners. However, there remains a lack of clarity in its definition and scholars argue that this can impacting the legitimacy of addressing social sustainability challenges. Through a systematic literature review and a content analysis, we shed light on the multifaceted discourse surrounding the concept of social sustainability, elucidating its diverse applications and meanings portrayed and defined within scholarly discourse. Our findings show that the concept predominantly revolves around four prevalent categories: “Equity,” “Well-being,” “Participation and Influence,” and ‘Social Capital. Based on results, we develop and present a novel analytical framework of the four pillars of social sustainability, referred to as the “SoSuCompass,” representing a conceptual framework to clarify the concept's multifaceted nature. The framework can serve as a tool for a fuller comprehension of the definition of social sustainability.
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| 5. |
- Nilsson, Caroline, 1984-, et al.
(författare)
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Navigating complexity with the four pillars of social sustainability
- 2024
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Ingår i: Sustainable Development. - . : Wiley. - 0968-0802 .- 1099-1719 .- 2160-7540 .- 2160-7559.
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Forskningsöversikt (refereegranskat)abstract
- The concept of social sustainability has long been a subject of discussion within academic literature and practitioners. However, there remains a lack of clarity in its definition and scholars argue that this can impacting the legitimacy of addressing social sustainability challenges. Through a systematic literature review and a content analysis, we shed light on the multifaceted discourse surrounding the concept of social sustainability, elucidating its diverse applications and meanings portrayed and defined within scholarly discourse. Our findings show that the concept predominantly revolves around four prevalent categories: Equity, Well-being, Participation and Influence, and 'Social Capital. Based on results, we develop and present a novel analytical framework of the four pillars of social sustainability, referred to as the SoSuCompass, representing a conceptual framework to clarify the concept's multifaceted nature. The framework can serve as a tool for a fuller comprehension of the definition of social sustainability.
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