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- Abdellah, Tebani, et al.
(författare)
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Integration of molecular profiles in a longitudinal wellness profiling cohort.
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies andimmune cell profiling, complementedwith gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
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- Ekengren, Fredrik, et al.
(författare)
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I tillvarons gränsland : Inledning
- 2009
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Ingår i: I tillvarons gränsland : Perspektiv på kroppen mellan liv och död - Perspektiv på kroppen mellan liv och död. - 0065-0994. - 9789189578289 ; 60, s. 4-17
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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- Magnusson, Peter S., et al.
(författare)
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SimICS/sun4m : A virtual workstation
- 2019
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Ingår i: USENIX 1998 Annual Technical Conference. - New Orleans, LA, USA : USENIX Association.
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Konferensbidrag (refereegranskat)abstract
- System level simulators allow computer architects and system software designers to recreate an accurate and complete replica of the program behavior of a target system, regardless of the availability, existence, or instrumentation support of such a system. Applications include evaluation of architectural design alternatives as well as software engineering tasks such as traditional debugging and performance tuning. We present an implementation of a simulator acting as a virtual workstation fully compatible with the sun4m architecture from Sun Microsystems. Built using the system-level SPARC V8 simulator SimICS, SimICS/sun4m models one or more SPARC V8 processors, supports user-developed modules for data cache and instruction cache simulation and execution profiling of all code, and provides a symbolic and performance debugging environment for operating systems. SimICS/sun4m can boot unmodified operating systems, including Linux 2.0.30 and Solaris 2.6, directly from snapshots of disk partitions. To support essentially arbitrary code, we implemented binary-compatible simulators for several devices, including SCSI, console, interrupt, timers, EEPROM, and Ethernet. The Ethernet simulation hooks into the host and allows the virtual workstation to appear on the local network with full services available (NFS, NIS, rsh, etc). Ethernet and console traffic can be recorded for future playback. The performance of SimICS/sun4m is sufficient to run realistic workloads, such as the database benchmark TPC-D, scaling factor 1/100, or an interactive network application such as Mozilla. The slowdown in relation to native hardware is in the range of 25 to 75 (measured using SPECint95). We also demonstrate some applications, including modeling an 8-processor sun4m version (which does not exist), modeling future memory hierarchies, and debugging an operating system.
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5. |
- Nilsson, Fredrik, et al.
(författare)
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Efterord
- 2017
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Ingår i: Kulturhistoria. En etnologisk metodbok.. - 2001-7529. ; 13
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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7. |
- Nilsson, Fredrik, et al.
(författare)
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Inledning
- 2007
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Ingår i: Öresundsgränser. Rörelser, möten och visioner i tid och rum. - 9789170610356 ; , s. 7-21
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Bokkapitel (refereegranskat)
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