| 1. |
- Ahrentorp, Fredrik, et al.
(författare)
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Sensitive magnetic biodetection using magnetic multi-core nanoparticles and RCA coils
- 2017
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 427, s. 14-18
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Tidskriftsartikel (refereegranskat)abstract
- We use functionalized iron oxide magnetic multi-core particles of 100 nm in size (hydrodynamic particle diameter) and AC susceptometry (ACS) methods to measure the binding reactions between the magnetic nanoparticles (MNPs) and bio-analyte products produced from DNA segments using the rolling circle amplification (RCA) method. We use sensitive induction detection techniques in order to measure the ACS response. The DNA is amplified via RCA to generate RCA coils with a specific size that is dependent on the amplification time. After about 75 min of amplification we obtain an average RCA coil diameter of about 1 mu m. We determine a theoretical limit of detection (LOD) in the range of 11 attomole (corresponding to an analyte concentration of 55 fM for a sample volume of 200 mu L) from the ACS dynamic response after the MNPs have bound to the RCA coils and the measured ACS readout noise. We also discuss further possible improvements of the LOD.
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| 2. |
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| 3. |
- Johansson, Ellen, et al.
(författare)
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Revising the embryonic origin of thyroid C cells in mice and humans
- 2015
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Ingår i: Development (Cambridge, England). - : The Company of Biologists. - 1477-9129 .- 0950-1991. ; 142:20, s. 3519-3528
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Tidskriftsartikel (refereegranskat)abstract
- Current understanding infers a neural crest origin of thyroid C cells, the major source of calcitonin in mammals and ancestors to neuroendocrine thyroid tumors. The concept is primarily based on investigations in quail-chick chimeras involving fate-mapping of neural crest cells to the ultimobranchial glands that regulate Ca(2+) homeostasis in birds, reptiles, amphibians and fishes, but whether mammalian C cell development implicates a homologous ontogenetic trajectory has not been experimentally verified. With lineage tracing we now provide direct evidence that Sox17+ anterior endoderm is the only source of differentiated C cells and their progenitors in mice. In similarity with many gut endoderm derivatives embryonic C cells were found to co-express pioneer factors forkhead box (Fox) a1 and Foxa2 before neuroendocrine differentiation takes place. In the ultimobranchial body epithelium emerging from pharyngeal pouch endoderm in early organogenesis differential Foxa1/Foxa2 expression distinguished two spatially separated pools of C cell precursors with different growth properties. A similar expression pattern was recapitulated in medullary thyroid carcinoma cells in vivo consistent with a growth-promoting role of Foxa1. Contrasting embryonic precursor cells, C cell-derived tumor cells invading the stromal compartment down-regulated Foxa2 foregoing epithelial-mesenchymal transition designated by loss of E-cadherin; both Foxa2 and E-cadherin were re-expressed at metastatic sites. These findings revise mammalian C cell ontogeny, expand the neuroendocrine repertoire of endoderm, and redefine the boundaries of neural crest diversification. The data further underpin distinct functions of Foxa1 and Foxa2 in both embryonic and tumor development.
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| 4. |
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| 5. |
- Nilsson, Jakob, 1975-
(författare)
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Capitalocene, cliches, and critical re-enchantment : What Akomfrah's Vertigo Sea does through BBC nature
- 2018
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Ingår i: Journal of Aesthetics & Culture. - : Taylor & Francis. - 2000-4214. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- In the montage of archival and original material that makes up John Akomfrah's three-channel video work Vertigo Sea (2015), the frequent use of footage shot by BBCs Natural History Unit (producers of series like Planet Earth) stands out as an unusual choice. This article explores aesthetic-political implications of how this material is subtly repurposed, with focus on one of the interconnected issues dealt with in the work: nature and the Capitaloscene. What does Vertigo Sea do to and through these BBC nature images? Which artistic strategies are involved and for which ends? Is the kind of ecological pathos already framing the original material itself critically transformed and if so in which senses? Does Vertigo Sea merely go for a reproduction of the natural beauty often attributed to original material, and as simply juxtaposed with terrible images, or does the repurposing also entail an alteration of the very notion of natural beauty? This article critically explores all these questions mainly through the frameworks of Situationist detournement, Deleuze's ideas about art and cliches, and Adorno's notions of authentic art, re-enchantment, and natural beauty-frameworks that are conversely critically discussed through Vertigo Sea. It aims to reveal Vertigo Sea as on the one hand an experiment in finding vital artistic strategies for re-enchanting (in non-idealizing ways) planetary nature in the Capitalocene, and as on the on the other hand a thematization of the difficulties in doing so. While appearing among a contemporary art scene increasingly concerned with local and/or global relations having to do with ecology in this new era, Vertigo Sea presents us with a highly original case primarily through its unusual choice of main source material and its complex treatment of this material.
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| 6. |
- Nilsson, Jakob, 1975-
(författare)
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Cinecepts, Deleuze, and Godard-Miéville : Developing Philosophy through Audiovisual Media
- 2023
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Bok (refereegranskat)abstract
- Develops a theory of cinecepts: a new framework for how philosophy can proceed in and through film/video/audiovisual mediaExplores how concepts – original philosophical concepts – can be constructed as compounds of moving images/sounds/voice/texts/graphics/montageBuilds on but also critically reexamines the work of Gilles Deleuze regarding the film/philosophy relation, concepts, and noveltySubjects Jean-Luc Godard and Anne-Marie Miéville’s 1970s video-works to extensive analysis, along with readings of two late-1960s Godard films and considerations of form in Histoire(s) du cinémaCritically explores debates and discourses on the ‘scholarly video essay’ and offers a cineceptual alternativeDraws together Film-Philosophy, Philosophy, Deleuze studies, Godard Studies, Film Theory, Art Theory, Media Theory, Critical Theory, and Videographic Film StudiesAs the spread of knowledge and even theory becomes an increasingly audiovisual affair, how can philosophy adapt in ways that develop – rather than dilute – philosophical rigor and specificity? How can philosophy harness the potential of audiovisual media – being more formally multidimensional than text-only – to conceptualize with greater precision and depth?This book presents a theory of formal development of philosophy in this regard: a theory of cinecepts. While spanning film, media, art, and critical theories as well as philosophy, this study proceeds mainly through a close reimagination of the work of Gilles Deleuze, which allows for a merging of what he kept separated: filmic thinking and philosophical conceptualization. Jean-Luc Godard & Anne-Marie Miéville's underexplored 1970s Sonimage works are also the subject of extensive examination, along with critical considerations of a contemporary era of academic video essays and phenomena like philosophy channels on YouTube.
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| 7. |
- Nilsson, Jakob, 1975-
(författare)
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Concept-Cognitive Mapping : Third Cinema as Cartography of Global Capitalism
- 2013
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Ingår i: Cinema & Cie. International Film Studies Journal. - Rome, Italy : Carocci editore. - 2035-5270. ; 13:20, s. 87-96
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Tidskriftsartikel (refereegranskat)abstract
- This article returns to the experimental theory and practice of Third Cinema as developed in the late 1960s in parts of Latin America. It focuses on two of its aspects that have not been systematically researched: Third Cinema as conceptualizations and maps of global capitalism. In doing so this article takes up and reconfigures Fredric Jameson's notion of "cognitive mapping" and introduce the theory concept-cognitive mapping. This latter theory aims to contribute new thoughts and perspectives to ongoing debates on aesthetic forms capable of a critical grasp of the mechanisms of advanced capitalism.
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| 8. |
- Nilsson, Jakob, 1975-
(författare)
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Deleuze, Concepts, and Ideas about Film as Philosophy : A Critical and Speculative Re-Examination
- 2018
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Ingår i: Journal of French and Francophone Philosophy. - Pittsburgh, PA, United States : University of Pittsburgh, University Library System. - 2155-1162 .- 1936-6280. ; 26:2, s. 127-149
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Tidskriftsartikel (refereegranskat)abstract
- This article explores the idea of film as a possible means for articulating original philosophical concepts, in Gilles Deleuze’s sense of concepts. The first of two parts, critically re-examines current ideas about film as philosophy in relation to Deleuze’s ideas on philosophy and cinema/art. It is common within the field of film-philosophy to trace back its central argument that film/cinema is capable of expressing original philosophy, to Deleuze’s cinema books. In and around these books, however, Deleuze did not express such an idea and rather underlined sharp formal differences between cinematic thinking and philosophy (however much he also described and implied proximities and similarities). Cinematic thinking takes the form, he argues, of blocks of movement/duration whereas philosophy is defined as the art of creating concepts. Still, could a close critical scrutiny of and some creativity with Deleuze’s thought allow for taking a step he did not take? The second part of the article takes on the speculative question of whether it is possible to create a notion from within Deleuze’s thought as a whole, that allows for at least the theoretical possibility of articulating original philosophical concepts – as Deleuze defines them (as a particular kind of multiplicity) – in and through film, and what this would mean for our understanding of the concrete form of concepts. The article examines Deleuze’s concept of concepts (how he defines their internal logic and by which formal means he implies that they can be articulated), his descriptions of complicating intersections between philosophy and art, some partly conflicting statements on Godard over the years, aspects of his analyses of filmic thinking in Cinema 2 that can be seen to provide preliminary components for articulating concepts in and through film, and it discusses the place and function of words and texts in such filmic articulations. If the aim of the first part is to clarify Deleuze’s positions on film and philosophy (often muddled in current film-philosophical writings) the aim of the second part resonates with the Deleuzian/Nietzschean quest for formal renewal of philosophy. The overall aim is to re-problematize and provide subtle new means for conceiving of and discussing the notion of film as philosophy.
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| 9. |
- Nilsson, Jakob, 1975-
(författare)
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Notes on Three Phases in Deleuze’s Thinking on Novelty
- 2020
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Ingår i: Material: Filosofi, Estetik, Arkitektur. - Huddinge : Södertörns högskola. - 9789188663993 - 9789189109001 ; , s. 155-164
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
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