| 1. |
- Roselli, Carolina, et al.
(författare)
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Multi-ethnic genome-wide association study for atrial fibrillation
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
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Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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| 4. |
- Engström, Hans, et al.
(författare)
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High power laser welding of thick construction steels
- 2000
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Ingår i: Proceedings of the Laser Materials Processing Conference.. - Orlando, Fla : Laser institute of America. - 0912035609 ; , s. A42-A51
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Konferensbidrag (refereegranskat)abstract
- Experimental results are reported from an investigation to develop a laser welding technique for welding thick (greater than 5 mm) construction steels. The construction steels investigated were: three grades of high strength Domex steels (6-8 mm thickness), high strength Weldox 500 (6 mm thickness) and wear resistant Hardox 400 (10-15 mm thickness). The following tests were performed to evaluate the laser welded joints: visual inspection, radiographic examination, macrophotographs, hardness, bending and tensile tests, and impact toughness tests. Three types of joint were studied: autogenous butt joints, filler welded butt joints and corner joints. Design opportunities for this process are also discussed.
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| 5. |
- Engström, Hans, et al.
(författare)
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Laser welding of thick structural steels
- 2001
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Ingår i: 8th NOLAMP, Proceedings. - Lyngby : Technical University of Denmark. - 8790855329 ; , s. 93-104
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Konferensbidrag (refereegranskat)abstract
- Experiments to determine process conditions for laser welding of thick structural steels are reported. Materials tested were: Domex 355, 460, 600 and 390, high strength, cold forming, microalloyed steels, 8-12 mm thickness; Weldox 960 high strength structural steel, 10 mm thickness; and Hardox 400 wear resistant steel, 10-15 mm thickness. Tests were performed using 12 and 17 kW lasers, with milled or laser cut edge preparation, various butt joint preparations, using autogenous and filler wire welding. Weld shape, microstructure and hardness, torsion fatigue strength, process envelopes for avoidance of solidification defects and laser optics requirements are reported.
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| 7. |
- Engström, Hans, et al.
(författare)
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Utveckling av lasersvetsteknik för detaljer i tjockt konstruktionsstål : ett projekt inom RACER - ett industristyrt utvecklingsprogram för laserbearbetning av abrasiv vattenstråleskärning
- 2000
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Svetsning med högeffektslaser erbjuder många fördelar jämfört med konventionella svetsmetoder; hög svetshastighet, låg eller oftast ingen förbrukning av tillsatsmaterial, lätt automatiserad, mycket hög svetskvalitet och framför allt liten värmepåverkan med liten, vanligen försumbar, formändring av arbetsstycket. CO2-lasrar med uteffekter på 20 kW samt den snabba utvecklingen av högeffekts Nd:YAG-laser kombinerad med fiberoptik erbjuder potentiellt stora utvecklingsmöjligheter för industriell användning inom området svetsning av tjocka material. F&U inom området lasersvetsning av tjock plåt pågår i Europa och är främst riktad mot varvsindustrin. I Sverige har ett initiativ tagits för att introducera tekniken hos tung fordons- och verkstadsindustri. Målet med projektet, som finansierats av NUTEK och deltagande projektpartners från industrin, har varit att vidareutveckla tekniken att lasersvetsa höghållfasta konstruktionsstål och introducera tekniken till i första hand tung fordons- och verkstadsindustri. Projektet har omfattat F&U av lasersvetsning av tjock plåt 8 - 15 mm i hållfasthetsområdet 280 - 960 MPa . Verkstadsindustriföretag och ståltillverkare har aktivt deltagit i projektet. Mekanisk hållfasthetsprovning och metallografiska studier av utförda svetsar har visat på mycket goda resultat i de flesta fall bättre än med konventionella svetsmetoder. Fortsatta försök med svetsade lådbalkar som tidigare provats avseende statisk hållfasthet och utmattningshållfasthet har uppvisat testresultat som överträffar de som svetsats med konventionella metoder. Svetsresultaten visar att lasersvetsning ger produktionsmässiga parameterfönster upp till plåttjocklek = 10 mm för de undersökta stålen. Från 12 mm och uppåt är resultaten hittills inte helt entydiga varför fortsatt utvecklingsarbete krävs för att öka förståelsen hos processen och för att vidareutveckla tekniken.
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| 8. |
- Haghighi, Mona, et al.
(författare)
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A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
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| 9. |
- Hammaréus, Filip, et al.
(författare)
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Wall shear stress measured with 4D flow CMR correlates with biomarkers of inflammation and collagen synthesis in mild-to-moderate ascending aortic dilation and tricuspid aortic valves
- 2024
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Ingår i: European Heart Journal Cardiovascular Imaging. - : OXFORD UNIV PRESS. - 2047-2404 .- 2047-2412.
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Tidskriftsartikel (refereegranskat)abstract
- Aims Understanding the mechanisms underlying ascending aortic dilation is imperative for refined risk stratification of these patients, particularly among incidentally identified patients, most commonly presenting with tricuspid valves. The aim of this study was to explore associations between ascending aortic haemodynamics, assessed using four-dimensional flow cardiovascular magnetic resonance imaging (4D flow CMR), and circulating biomarkers in aortic dilation. Methods and results Forty-seven cases with aortic dilation (diameter >= 40 mm) and 50 sex-and age-matched controls (diameter < 40 mm), all with tricuspid aortic valves, underwent 4D flow CMR and venous blood sampling. Associations between flow displacement, wall shear stress (WSS), and oscillatory shear index in the ascending aorta derived from 4D flow CMR, and biomarkers including interleukin-6, collagen type I alpha 1 chain, metalloproteinases (MMPs), and inhibitors of MMPs derived from blood plasma, were investigated. Cases with dilation exhibited lower peak systolic WSS, higher flow displacement, and higher mean oscillatory shear index compared with controls without dilation. No significant differences in biomarkers were observed between the groups. Correlations between haemodynamics and biomarkers were observed, particularly between maximum time-averaged WSS and interleukin-6 (r = 0.539, P < 0.001), and maximum oscillatory shear index and collagen type I alpha 1 chain (r = -0.575, P < 0.001 in cases). Conclusion Significant associations were discovered between 4D flow CMR derived whole-cardiac cycle WSS and circulating biomarkers representing inflammation and collagen synthesis, suggesting an intricate interplay between haemodynamics and the processes of inflammation and collagen synthesis in patients with early aortic dilation and tricuspid aortic valves.
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