| 1. |
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| 2. |
- Allard, Christina, et al.
(författare)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby : DN Debatt 2015-06-11
- 2015
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Annan publikation (populärvet., debatt m.m.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 3. |
- Alänge, Sverker, 1951, et al.
(författare)
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Ledarskap ur koncernchefsperspektiv
- 1998
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Många tecken tyder på att vi är mitt inne i ett paradigmskifte, där ett nytt sätt att bedriva verksamhet påverkar såväl tillverkande industri som privat och offentlig serviceverksamhet. Detta nya sätt att bedriva verksamhet karakteriseras av att samtliga människor inom en organisation engageras i att använda alla sina resurser, inklusive sin inneboende kreativitet, till att på bästa sätt tillgodose eller överträffa kunders förväntningar. Denna förändring ställer i sin tur nya krav på ledarstil, förankring av visioner och mål, motivationssystem, kontinuerligt lärande och processynsätt. Toppledarens betydelse för större förändringar i inriktning och grundläggande värderingar, dvs. ett paradigmskifte, har påpekats av många forskare och i litteraturen förekommer flera exempel på betydelsen av toppledares involvering och engagemang i större förändringsprocesser, både från Sverige och i internationella företag. Boken baseras på intervjuer med tolv koncernchefer vid några av Sveriges största företag: Astra, Electrolux, Posten, SAS, S-E Banken, SJ, Skandia, SKF, Stora, Telia, Tetra-Laval och Vattenfall. Boken presenterar och analyserar koncernchefernas samlade syn på ledarskap och krav på ledaregenskaper, idag och i framtiden. Boken innehåller även en jämförelse med andra ledares uppfattning om ledarskap. På frågor om morgondagens ledarskap; om vad koncerncheferna anser kommer att krävas av storföretagsledare i framtiden och om finns det behov av att förändra och utveckla dagens ledarskap kan svaren sammanfattas i fyra behov: Integritet, förmåga att få med sig sina medarbetare, mångkulturell kompetens samt förmåga att hantera ny teknologi och nya organisationsformer. Dessutom betonade några chefer vikten av att inse att framtidens krav är dagens verklighet, dvs. att framtiden redan är här.
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| 4. |
- Ameur, Adam, et al.
(författare)
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SweGen : a whole-genome data resource of genetic variability in a cross-section of the Swedish population
- 2017
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Ingår i: European Journal of Human Genetics. - : NATURE PUBLISHING GROUP. - 1018-4813 .- 1476-5438. ; 25:11, s. 1253-1260
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Tidskriftsartikel (refereegranskat)abstract
- Here we describe the SweGen data set, a comprehensive map of genetic variation in the Swedish population. These data represent a basic resource for clinical genetics laboratories as well as for sequencing-based association studies by providing information on genetic variant frequencies in a cohort that is well matched to national patient cohorts. To select samples for this study, we first examined the genetic structure of the Swedish population using high-density SNP-array data from a nation-wide cohort of over 10 000 Swedish-born individuals included in the Swedish Twin Registry. A total of 1000 individuals, reflecting a cross-section of the population and capturing the main genetic structure, were selected for whole-genome sequencing. Analysis pipelines were developed for automated alignment, variant calling and quality control of the sequencing data. This resulted in a genome-wide collection of aggregated variant frequencies in the Swedish population that we have made available to the scientific community through the website https://swefreq.nbis.se. A total of 29.2 million single-nucleotide variants and 3.8 million indels were detected in the 1000 samples, with 9.9 million of these variants not present in current databases. Each sample contributed with an average of 7199 individual-specific variants. In addition, an average of 8645 larger structural variants (SVs) were detected per individual, and we demonstrate that the population frequencies of these SVs can be used for efficient filtering analyses. Finally, our results show that the genetic diversity within Sweden is substantial compared with the diversity among continental European populations, underscoring the relevance of establishing a local reference data set.
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| 6. |
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| 7. |
- Bergquist, Magnus, 1983, et al.
(författare)
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Meta-analyses of fifteen determinants of public opinion about climate change taxes and laws
- 2022
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Ingår i: Nature Climate Change. - : Springer Science and Business Media LLC. - 1758-678X .- 1758-6798. ; 12, s. 235-240
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Tidskriftsartikel (refereegranskat)abstract
- Public acceptance is a precondition for implementing taxes and laws aimed at mitigating climate change. However, it still remains challenging to understand its determinants for the climate community. Here, we use a meta-analytic approach to examine the role of public opinion about climate change taxes and laws. Fifteen variables were examined by synthesizing 89 datasets from 51 articles across 33 countries, with a total sample of 119,465 participants. Among all factors, perceived fairness and effectiveness were the most important determinants. Self-enhancement values and knowledge about climate change showed weak relationships and demographic variables showed only weak or close to zero effects. Our meta-analytic results provide useful insights and have the potential to inform climate change researchers, practitioners and policymakers to better design climate policy instruments.
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| 8. |
- Bram Ednersson, Susanne, et al.
(författare)
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Expression of ribosomal and actin network proteins and immunochemotherapy resistance in diffuse large B cell lymphoma patients
- 2018
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 181:6, s. 770-781
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Tidskriftsartikel (refereegranskat)abstract
- Diffuse large B cell lymphoma (DLBCL) patients with early relapse or refractory disease have a very poor outcome. Immunochemotherapy resistance will probably, also in the era of targeted drugs, remain the major cause of treatment failure. We used proteomic mass spectrometry to analyse the global protein expression of micro-dissected formalin-fixed paraffin-embedded tumour tissues from 97 DLBCL patients: 44 with primary refractory disease or relapse within 1year from diagnosis (REF/REL), and 53 who were progression-free more than 5years after diagnosis (CURED). We identified 2127 proteins: 442 were found in all patients and 102 were differentially expressed. Sixty-five proteins were overexpressed in REF/REL patients, of which 46 were ribosomal proteins (RPs) compared with 2 of the 37 overexpressed proteins in CURED patients (P=76x10(-10)). Twenty of 37 overexpressed proteins in CURED patients were associated with actin regulation, compared with 1 of 65 in REF/REL patients (P=14x10(-9)). Immunohistochemical staining showed higher expression of RPS5 and RPL17 in REF/REL patients while MARCKS-like protein, belonging to the actin network, was more highly expressed in CURED patients. Even though functional studies aimed at individual proteins and protein interactions to evaluate potential clinical effect are needed, our findings suggest new mechanisms behind immunochemotherapy resistance in DLBCL.
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| 9. |
- Bram Ednersson, Susanne, et al.
(författare)
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TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma
- 2020
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Ingår i: Leukemia & Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 61:11, s. 2595-2604
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have identified prognostic mutational clusters for diffuse large B-cell lymphoma (DLBCL) patients, both within and outside the original cell-of-origin (COO) classification. For many of these mutations, there is limited information regarding the corresponding protein expression. With the aim to determine the relationship of protein expression and intensity to COO and prognosis, we used digital image analysis to quantitate immunohistochemical staining of CREBBP, IRF8, EZH2, and TBLR1 in 209 DLBCL patients. We found that patients with strong nuclear expression of TBLR1 had inferior progression-free survival (PFS) and overall survival (OS) in univariable analysis and inferior PFS in multivariable analysis. Patients with higher proportion of intermediate to strong nuclear CREBBP expression had a worse PFS and OS in univariable analysis. CREBBP was expressed with stronger intensity in non-GCB patients and the prognostic impact was restricted to this subgroup. These findings suggest that high nuclear protein expression of TBLR1 and CREBBP is negatively associated with prognosis in DLBCL.
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| 10. |
- Bäckström, Åsa, 1966-
(författare)
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Spår : Om brädsportkultur, informella lärprocesser och identitet
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Today’s society is subject to an increased importance of aesthetics and an increasing individualism. New trends are adopted early by young people, which make it interesting to focus on how identity is formed and meanings are constructed in a youth culture context and in relation to ongoing societal processes of change.The purpose of this dissertation is to interpret and analyse the construction of meaning within the skateboard and snowboard communities in the social and cultural contexts. In particular, this dissertation is about the relationship between three levels, cultural, practice and individual. The title “Traces” alludes to four analytical themes taking different tracks in the book; consumption, gender, place and identity that are reflected in different chapters. However, the individual leaves traces in culture as culture does in the individual. Furthermore, skaters and snowboarders leave actual tracks in their local geography.Theoretically the study has a culture analysis approach with a semiotic base where five theories are intertwined. Johan Fornäs contributes with his interpretation on culture as system of signs and signifying practices, Stuart Hall adds the concept of representations, Kirsten Drotner provides her argumentation regarding aesthetic practices whilst Ulf Hannerz enriches the dissertation with his discussion on transnational culture-flows and the social diffusion of culture. Roger Säljö proposes a socio-cultural perspective of learning where learning is about participation in knowledge and skills. The method used is ethnographical. The multifaceted empirical material, from field studies and interviews, Swedish skateboard and snowboard magazines between 1978 to 2002, skateboard and snowboard videos, press articles, and websites, has been triangulated. In addition, there are three personal albums of skateboarder, snowboarder and surfer Ants Neo.The study shows that there are stereotyped notions about what boarding means and what it means to be a boarder. These notions both create and are created by the boarders themselves but are also used by advertisers for products not related to board sports at all. These notions, based as they are on ideas of resistance and radicalism, serve to emphasise that boarding is masculine. Resistance takes concrete form in its attitude to organized sports and to multinational brands and in the unusual use of places in the urban environment. To be a boarder is, apart form the boarding skills required, to be also part and parcel of these attitudes.The study explains how meaning and identity are created through informal learning processes in youth culture contexts. In these group-forming processes, both the individual and the community are formulated in social, cultural and aesthetic terms.
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