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- In ’t Veld, Sjors G.J.G., et al.
(författare)
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Detection and localization of early- and late-stage cancers using platelet RNA
- 2022
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Ingår i: Cancer Cell. - : Elsevier. - 1535-6108 .- 1878-3686. ; 40:9, s. 999-1009.e6
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Tidskriftsartikel (refereegranskat)abstract
- Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
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| 2. |
- Wamsler, Christine, et al.
(författare)
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Operationalizing ecosystem-based adaptation : harnessing ecosystem services to buffer communities against climate change
- 2016
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Ingår i: Ecology and Society. - : Resiliance Alliance. - 1708-3087. ; 31:1
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT. Ecosystem-based approaches for climate change adaptation are promoted at international, national, and local levels by both scholars and practitioners. However, local planning practices that support these approaches are scattered, and measures are neither systematically implemented nor comprehensively reviewed. Against this background, this paper advances the operationalization of ecosystem-based adaptation by improving our knowledge of how ecosystem-based approaches can be considered in local planning (operational governance level). We review current research on ecosystem services in urban areas and examine four Swedish coastal municipalities to identify the key characteristics of both implemented and planned measures that support ecosystem-based adaptation. The results show that many of the measures that have been implemented focus on biodiversity rather than climate change adaptation, which is an important factor in only around half of all measures. Furthermore, existing measures are limited in their focus regarding the ecological structures and the ecosystem services they support, and the hazards and risk factors they address. We conclude that a more comprehensive approach to sustainable ecosystem-based adaptation planning and its systematic mainstreaming is required. Our framework for the analysis of ecosystem-based adaptation measures proved to be useful in identifying how ecosystem-related matters are addressed in current practice and strategic planning, and in providing knowledge on how ecosystem-based adaptation can further be considered in urban planning practice. Such a systematic analysis framework can reveal the ecological structures, related ecosystem services, and risk-reducing approaches that are missing and why. This informs the discussion about why specific measures are not considered and provides pathways for alternate measures/designs, related operations, and policy processes at different scales that can foster sustainable adaptation and transformation in municipal governance and planning. Key Words: climate change adaptation; ecosystem management; ecosystem services; green infrastructure; municipal planning; naturebased solutions; renaturing cities; risk reduction; spatial planning; sustainability transitions; urban planning; urban resilience; urban transformation
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