| 1. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 2. |
- Edgerton, Michael, et al.
(författare)
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The Extra-Normal Voice
- 2019
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Ingår i: The Oxford Handbook of Singing. - 9780199660773
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Bokkapitel (refereegranskat)abstract
- This chapter presents an overview of new developments in vocal exploration. Beginning with a discussion of multiple parameters involved in voice production, this chapter identifies the crucial role that non-linear phenomena has in the performance of the extra-normal voice. In this article, two related taxonomies are presented (source production related to degree of voicing; emphases within the acoustic framework of power, source, resonance, and articulation) that may be used as powerful generative tools for the production of multiple sound sources, filtering processes, and aerodynamic effects, etc. The paper then posits how scaled, multidimensional networks may be used to intelligently explore all elements of the acoustic sound production apparatus and not solely articulation, as is seen with some proponents of complex networks. In this discussion, it will be presented how fully scaling each parameter space will encompass far reaching benefits by engaging with little traversed regions of the total vocal topography.
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| 3. |
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| 4. |
- Nix, John, et al.
(författare)
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Acoustical, psychoacoustical, and pedagogical considerations for choral singing with covid-19 health measures
- 2020
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Ingår i: Choral Journal. - Oklahoma City : American Choral Directors Association. - 0009-5028 .- 2163-2170. ; 61:3, s. 32-40
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Tidskriftsartikel (refereegranskat)abstract
- The COVID-19 pandemic has had a tremendous impact on many aspects of daily life. Accepted means for safely gathering persons for any activity include meeting outdoors if possible, maintaining 2 or more meters (6 feet) physical distance between persons, using high ventilation rates (preferably natural ventilation) to provide multiple air changes per hour if indoors, and wearing masks to prevent the spread of larger droplets. However, applying these health practices to choral singing has significant implications for the nature of the sound a choir creates, the perception of the choir’s sound both within and outside of the choir, and the vocal production of the singers. In this article, we hope to examine a few of these implications in more detail and to provide some suggestions for how best to respond, based on prior research in the acoustics and psychoacoustics of choral singing, stressing as always that observing necessary health measures is paramount.
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