| 1. |
- Furukawa, T. A., et al.
(author)
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Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual data
- 2021
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In: Lancet Psychiatry. - : Elsevier BV. - 2215-0374 .- 2215-0366. ; 8:6, s. 500-511
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Journal article (peer-reviewed)abstract
- Findings We identified 76 RCTs, including 48 trials contributing individual participant data (11 704 participants) and 28 trials with aggregate data (6474 participants). The participants' weighted mean age was 42.0 years and 12 406 (71%) of 17 521 reported were women. There was suggestive evidence that behavioural activation might be beneficial (iMD -1.83 [95% credible interval (CrI) -2.90 to -0.80]) and that relaxation might be harmful (1.20 [95% CrI 0.17 to 2.27]). Baseline severity emerged as the strongest prognostic factor for endpoint depression. Combining human and automated encouragement reduced dropouts from treatment (incremental odds ratio, 0.32 [95% CrI 0.13 to 0.93]). The risk of bias was low for the randomisation process, missing outcome data, or selection of reported results in most of the included studies, uncertain for deviation from intended interventions, and high for measurement of outcomes. There was moderate to high heterogeneity among the studies and their components. 511
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| 2. |
- Fisher, Rachel S., et al.
(author)
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Pulse-shaped two-photon excitation of a fluorescent base analogue approaches single-molecule sensitivity
- 2018
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In: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9084 .- 1463-9076. ; 20:45, s. 28487-28498
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Journal article (peer-reviewed)abstract
- Fluorescent nucleobase analogues (FBAs) have many desirable features in comparison to extrinsic fluorescent labels, but they are yet to find application in ultrasensitive detection. Many of the disadvantages of FBAs arise from their short excitation wavelengths (often in the ultraviolet), making two-photon excitation a potentially attractive approach. Pentacyclic adenine (pA) is a recently developed FBA that has an exceptionally high two-photon brightness. We have studied the two-photon-excited fluorescence properties of pA and how they are affected by incorporation in DNA. We find that pA is more photostable under two-photon excitation than via resonant absorption. When incorporated in an oligonucleotide, pA has a high two-photon cross section and emission quantum yield, varying with sequence context, resulting in the highest reported brightness for such a probe. The use of a two-photon microscope with ultrafast excitation and pulse shaping has allowed the detection of pA-containing oligonucleotides in solution with a limit of detection of ∼5 molecules, demonstrating that practical single-molecule detection of FBAs is now within reach.
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| 3. |
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| 4. |
- Idoia Biurrun, Idoia, et al.
(author)
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GrassPlot v. 2.00 – first update on the database of multi-scale plant diversity in Palaearctic grasslands
- 2019
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In: Palaearctic Grasslands. - : Eurasian Dry Grassland Group (EDGG). - 2627-9827. ; :44, s. 26-47
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Journal article (peer-reviewed)abstract
- GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). Following a previous Long Database Report (Dengler et al. 2018, Phytocoenologia 48, 331–347), we provide here the first update on content and functionality of GrassPlot. The current version (GrassPlot v. 2.00) contains a total of 190,673 plots of different grain sizes across 28,171 independent plots, with 4,654 nested-plot series including at least four grain sizes. The database has improved its content as well as its functionality, including addition and harmonization of header data (land use, information on nestedness, structure and ecology) and preparation of species composition data. Currently, GrassPlot data are intensively used for broad-scale analyses of different aspects of alpha and beta diversity in grassland ecosystems.
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| 6. |
- Nobis, Harrison, et al.
(author)
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Modal laminar–turbulent transition delay by means of topology optimization of superhydrophobic surfaces
- 2023
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In: Computer Methods in Applied Mechanics and Engineering. - : Elsevier. - 0045-7825 .- 1879-2138. ; 403:Part A
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Journal article (peer-reviewed)abstract
- When submerged under a liquid, the microstructure of a SuperHydrophobic Surface (SHS) traps a lubricating layer of gas pockets, which has been seen to reduce the skin friction of the overlying liquid flow in both laminar and turbulent regimes. More recently, spatially homogeneous SHS have also been shown to delay laminar–turbulent transition in channel flows, where transition is triggered by modal mechanisms. In this study, we investigate, by means of topology optimization, whether a spatially inhomogeneous SHS can be designed to further delay transition in channel flows. Unsteady direct numerical simulations are conducted using the spectral element method in a 3D periodic wall-bounded channel. The effect of the SHS is modelled using a partial slip length on the walls, forming a 2D periodic optimization domain. Following a density-based approach, the optimization procedure uses the adjoint-variable method to compute gradients and a checkpointing strategy to reduce storage requirements. This methodology is adapted to optimizing over an ensemble of initial perturbations. This study presents the first application of topology optimization to laminar–turbulent transition. We show that this method can design surfaces that delay transition significantly compared to a homogeneous counterpart, by inhibiting the growth of secondary instability modes. By optimizing over an ensemble of streamwise phase-shifted perturbations, designs have been found with comparable mean transition time and lower variance.
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| 7. |
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| 8. |
- Nobis, Harrison, et al.
(author)
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Topology optimization of Superhydrophobic Surfaces to delay spatially developing modal laminar–turbulent transition
- 2023
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In: International Journal of Heat and Fluid Flow. - : Elsevier. - 0142-727X .- 1879-2278. ; 104
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Journal article (peer-reviewed)abstract
- Super-Hydrophobic Surfaces (SHSs) have been shown to reduce skin friction of an overlying fluid as a consequence of gas pockets trapped within the surface’s microstructure. More recently, they have also been shown capable of delaying laminar–turbulent transition. This article investigates the applicability of topology optimization in designing the macroscopic layout of SHSs in a channel that are able to further delay K-type transition in a spatial setting. Unsteady direct numerical simulations are performed to simulate the transition scenario. This is coupled with adjoint–based sensitivity analysis and gradient based optimization. The optimized designs found through this procedure are capable of moving the transition location further downstream compared to a homogeneous counterpart by inhibiting the growth of secondary instability modes. This article provides the first application of topology optimization to a spatially developing transition scenario.
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| 9. |
- Nobis, Harrison, et al.
(author)
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Topology optimization of unsteady flows using the spectral element method
- 2022
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In: Computers & Fluids. - : Elsevier. - 0045-7930 .- 1879-0747. ; 239
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Journal article (peer-reviewed)abstract
- We investigate the applicability of a high-order Spectral Element Method (SEM) to density based topology optimization of unsteady flows in two dimensions. Direct Numerical Simulations (DNS) are conducted relying on Brinkman penalization to describe the presence of solid within the domain. The optimization procedure uses the adjoint-variable method to compute gradients and a checkpointing strategy to reduce storage requirements. A nonlinear filtering strategy is used to both enforce a minimum length scale and to provide smoothing across the fluid-solid interface, preventing Gibbs oscillations. This method has been successfully applied to the design of a channel bend and an oscillating pump, and demonstrates good agreement with body fitted meshes. The precise design of the pump is shown to depend on the initial material distribution. However, the underlying topology and pumping mechanism is the same. The effect of a minimum length scale has been studied, revealing it to be a necessary regularization constraint for the oscillating pump to produce meaningful designs. The combination of SEM and density based optimization offer some unique challenges which are addressed and discussed, namely a lack of explicit boundary tracking exacerbated by the interface smoothing. Nevertheless, SEM can achieve equivalent levels of precision to traditional finite element methods, while requiring fewer degrees of freedom. Hence, the use of SEM addresses the two major bottlenecks associated with optimizing unsteady flows: computation cost and data storage.
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