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Sökning: WFRF:(Noirot C)

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  • Kobir, A., et al. (författare)
  • Phosphorylation of Bacillus subtilis gene regulator AbrB modulates its DNA-binding properties
  • 2014
  • Ingår i: Molecular Microbiology. - : Wiley. - 1365-2958 .- 0950-382X. ; 92:5, s. 1129-1141
  • Tidskriftsartikel (refereegranskat)abstract
    • AbrB is a global gene regulator involved in transition phase phenomena in Bacillus subtilis. It participates in a complex regulatory network governing the expression of stationary-phase functions. AbrB was previously found to be phosphorylated on serine 86 located close to its C-terminal oligomerization domain. Here we report that AbrB can be phosphorylated by three B. subtilis serine/threonine kinases expressed during the transition and stationary phase: PrkC, PrkD and YabT. Our in vitro findings suggest that AbrB phosphorylation impedes its DNA binding and abolishes binding cooperativity. In vivo we established that a phospho-mimetic mutation abrB S86D leads to a significant loss of AbrB control over several key target functions: exoprotease production, competence development and sporulation. A wider transcriptome analysis of abrBS86D and S86A mutant strains revealed deregulation of a large number of target genes. We therefore propose that AbrB phosphorylation serves as an additional input for fine-tuning the activity of this ambiactive gene regulator.
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