| 1. |
- Albinsson, Linda, et al.
(författare)
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Swedish population data and concordance for the kits PowerPlexÒ ESX 16 System, PowerPlexÒ ESI 16 System, AmpFlSTRÒ NGMTM, AmpFlSTRÒ SGM PlusTM and Investigator ESSplex
- 2011
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Ingår i: Forensic Science International. - Clare, Irland : Elsevier. - 1872-4973 .- 1878-0326. ; 5:3, s. e89-e92
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The European Standard Set of loci (ESS) has been extended with five additional short tandem repeat (STR) loci following the recommendations of the European Network of Forensic Science Institutes (ENFSI) and the European DNA Profiling Group (EDNAP) to increase the number of loci routinely used by the European forensic community. Subsequently, a new extended Swedish population database, based on 425 individuals, has been assembled using the new STR multiplex kits commercially available.Allele frequencies and statistical parameters of forensic interest for 15 autosomal STR loci (D3S1358, TH01, D21S11, D18S51, D10S1248, D1S1656, D2S1338, D16S539, D22S1045, vWA, D8S1179, FGA, D2S441, D12S391 and D19S433) were obtained from the analysis of the PowerPlex® ESX 16 System kit (Promega Corporation, USA). According to the data no evidence of deviations from Hardy–Weinberg equilibrium was found. The observed heterozygosity varies between 0.755 (TH01) and 0.892 (D1S1656). The power of discrimination was smallest for D22S1045 (0.869) and largest for D1S1656 (0.982) while the power of exclusion was smallest for TH01 (0.518) and largest for D1S1656 (0.778).A concordance study was performed on the five amplification systems: PowerPlex® ESX 16 System, PowerPlex® ESI 16 System (Promega Corporation, USA), AmpFlSTR® NGM™, AmpFlSTR® SGM Plus™ (Applied Biosystems, USA) and Investigator ESSplex (Qiagen, Germany) to reveal null alleles and other divergences between the kits. For the 425 DNA profiles included, AmpFlSTR® NGM™ revealed two null alleles, AmpFlSTR® SGM Plus™ revealed one, and Investigator ESSplex revealed a micro-variant, while the rest of the alleles showed full concordance between the kits tested.
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| 2. |
- Norén, L., et al.
(författare)
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Purification of crime scene DNA extracts using centrifugal filter devices
- 2013
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Ingår i: Investigative Genetics. - : Springer Science and Business Media LLC. - 2041-2223. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The success of forensic DNA analysis is limited by the size, quality and purity of biological evidence found at crime scenes. Sample impurities can inhibit PCR, resulting in partial or negative DNA profiles. Various DNA purification methods are applied to remove impurities, for example, employing centrifugal filter devices. However, irrespective of method, DNA purification leads to DNA loss. Here we evaluate the filter devices Amicon Ultra 30 K and Microsep 30 K with respect to recovery rate and general performance for various types of PCR-inhibitory crime scene samples. Methods: Recovery rates for DNA purification using Amicon Ultra 30 K and Microsep 30 K were gathered using quantitative PCR. Mock crime scene DNA extracts were analyzed using quantitative PCR and short tandem repeat (STR) profiling to test the general performance and inhibitor-removal properties of the two filter devices. Additionally, the outcome of long-term routine casework DNA analysis applying each of the devices was evaluated. Results: Applying Microsep 30 K, 14 to 32% of the input DNA was recovered, whereas Amicon Ultra 30 K retained 62 to 70% of the DNA. The improved purity following filter purification counteracted some of this DNA loss, leading to slightly increased electropherogram peak heights for blood on denim (Amicon Ultra 30 K and Microsep 30 K) and saliva on envelope (Amicon Ultra 30 K). Comparing Amicon Ultra 30 K and Microsep 30 K for purification of DNA extracts from mock crime scene samples, the former generated significantly higher peak heights for rape case samples (P-values <0.01) and for hairs (P-values <0.036). In long-term routine use of the two filter devices, DNA extracts purified with Amicon Ultra 30 K were considerably less PCR-inhibitory in Quantifiler Human qPCR analysis compared to Microsep 30 K. Conclusions: Amicon Ultra 30 K performed better than Microsep 30 K due to higher DNA recovery and more efficient removal of PCR-inhibitory substances. The different performances of the filter devices are likely caused by the quality of the filters and plastic wares, for example, their DNA binding properties. DNA purification using centrifugal filter devices can be necessary for successful DNA profiling of impure crime scene samples and for consistency between different PCR-based analysis systems, such as quantification and STR analysis. In order to maximize the possibility to obtain complete STR DNA profiles and to create an efficient workflow, the level of DNA purification applied should be correlated to the inhibitor-tolerance of the STR analysis system used.
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| 3. |
- Norén, Ronny, 1951-
(författare)
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A Takayama-Judge activity model applied to the analysis of allocation and trade in Sweden
- 1991
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Ingår i: Applied Economics. - London : Routledge, Taylor group. - 0003-6846. ; 23:7, s. 1201-1212
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this chapter[1] is to formulate a numerical general equilibrium model of the Swedish economy, and to use the model for a quantitative evaluation of the pattern of comparative advan-tages. The model is essentially a Leontief type of input-output model, extended with linear demand functions for final com-modities, foreign trade activities and capacity and resource constraints. Due to the linearity the model can easily be reformulated and solved as a quadratic programming model. The evaluation of the pattern of comparative advantages of the Swedish economy is carried out as an analysis of the choice between import and domestic production in a temporary equilibrium framework with exogenously given world market prices, exports and domestic production capacities.
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| 4. |
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| 5. |
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| 6. |
- Norén, Ronny
(författare)
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Comparative advantages revealed : experiments with a quadratic programming model of Sweden
- 1987
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- The explicit aim of this study is to adapt a model to the particular problem for estimating the comparative advantages in domestic production and trade for the Swedish economy, develop the data required, explore and demonstrate the major features and capabilities of the model. The concept of a quadratic quasi-welfare function, generated along the lines of producer and consumer surplus, forms the basis for the specification of a linear activity model where both prices and quantities are determined endogenously. Although the model is simple, the experiments do illustrate, besides identifying structural imbalances, very well the inherent possibilities and limitations as a general framework for structural analysis.
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| 7. |
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| 8. |
- Norén, Ronny
(författare)
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Dismissal of Employees in Swedish Manufacturing
- 2004
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Ingår i: Journal of Policy Modeling. - : Elsevier BV. - 0161-8938. ; 26:2, s. 151-164
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines the macroeconomic influence of the numbers of employees who received notice of dismissal or lay off, in the Swedish manufacturing industry during the period 1980–1994. Given the assumption of fixed labour requirements after the installation of new capital equipments, the statistics over the employees who received notice of dismissal or lay off can be assumed to be closely related to disinvestment. The obtained empirical results suggest that most of the estimated variables are highly significant, both in size and magnitude. The estimations also indicate a significant difference in response to the development of some of the explanatory variables. These findings are reflected in the structural adjustment process of the Swedish manufacturing sector and the general domestic policy by the government
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| 9. |
- Norén, Ronny
(författare)
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Ekonomisk aktivitet, omvandling och entreprenörskap
- 2013
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Ingår i: Ekonomiska samfundets tidskrift. - 0013-3183 .- 2323-1378. ; 66:3, s. 178-186
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Tidskriftsartikel (refereegranskat)abstract
- The increased knowledge that there exists connections between entry rates into entrepreneurship and the business cycle creates room for economic policy, to moderate the effects of the business cycle, and also influence the entry rates. In addition, increased structural transformation in the economy also creates room for new economic activities. The knowledge-intensive manufacturing industry in Sweden has in relative size been reduced. Measures to counteract this development is to increase innovations, patents, and new business formation. Thus, the challenge is to create room for an increasing support of the entry of entrepreneurship by economic policy.
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| 10. |
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