| 1. |
- Hagmar, L, et al.
(författare)
-
Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose
- 2001
-
Ingår i: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 27:4, s. 219-226
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: This study assessed the health effects of occupational acrylamide exposure using hemoglobin (Hb) adducts as biomarkers of internal dose. METHODS: Two hundred and ten tunnel workers exposed for about 2 months to a chemical-grouting agent containing acrylamide and N-methylolacrylamide underwent a health examination. Blood samples were drawn for the analysis of Hb adducts of acrylamide. Fifty workers claiming recently developed or deteriorated symptoms of the peripheral nervous system (PNS) were referred to a neurophysiological examination. Workers with Hb-adduct levels exceeding 0.3 nmol/g globin attended follow-up examinations 6, 12, and 18 months after exposure cessation. RESULTS: Forty-seven workers had Hb-adduct levels within the normal background range (0.02-0.07 nmol/g globin), while the remaining 163 had increased levels up to a maximum of 17.7 nmol/g globin. Clear-cut dose-response associations were found between the Hb-adduct levels and PNS symptoms. Thirty-nine percent of those with Hb-adduct levels exceeding 1 nmol/g globin experienced tingling or numbness in their hands or feet. A no-observed adverse effect level of 0.51 nmol/g globin was estimated for numbness or tingling in the feet or legs. For 23 workers there was strong evidence of PNS impairment due to occupational exposure to acrylamide. All but two had recovered 18 months after the cessation of exposure. CONCLUSIONS: Occupational exposure to a grouting agent containing acrylamide resulted in PNS symptoms and signs. The use of Hb adducts of acrylamide as a biomarker of internal dose revealed strong dose-response associations. The PNS symptoms were, however, generally mild, and in almost all cases they were reversible.
|
|
| 2. |
- Ingvar, C., et al.
(författare)
-
Long-term outcome of pT1a–b, cN0 breast cancer without axillary dissection or staging : a prospective observational study of 1543 women
- 2020
-
Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 107:10, s. 1299-1306
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The implementation of screening programmes in Sweden during the mid-1990s increased the number of small node-negative breast cancers. In this era before staging by sentinel node biopsy, routine axillary dissection for staging of early breast cancer was questioned owing to the increased morbidity and lack of perceived benefit. The long-term risk of axillary recurrence when axillary staging is omitted remains unclear. Methods: This prospective observational multicentre cohort study included Swedish women diagnosed with breast cancer between 1997 and 2002. The patients had clinically node-negative, pT1a–b, grade I–II tumours. No axillary staging or dissection was performed. The primary outcome was ipsilateral axillary recurrence and survival. Results: A total of 1543 patients were included. Breast-conserving surgery (BCS) was performed in 94·0 per cent and the rest underwent mastectomy. After surgery, 58·1 per cent of the women received adjuvant radiotherapy, 11·9 per cent adjuvant endocrine therapy and 31·5 per cent did not receive any adjuvant treatment. After a median follow-up of 15·5 years, 6·4 per cent developed contralateral breast cancer and 16·5 per cent experienced a recurrence. The first recurrence was local in 116, regional in 47 and distant in 59 patients. The breast cancer-specific survival rate was 93·7 per cent after 15 years. There were no differences in overall or breast cancer-specific survival between patients who received adjuvant radiotherapy and those who did not. Only 3·0 per cent of patients had an axillary recurrence, which was isolated in only 1·0 per cent. Conclusion: Axillary surgery can safely be omitted in patients with low-grade, T1a–b, cN0 breast cancers. This large prospective cohort with 15-year follow-up had a very low incidence of axillary recurrences and high breast cancer-specific survival rate.
|
|
| 3. |
- Mathiassen, Svend Erik, et al.
(författare)
-
Task-based estimation of mechanical job exposure in occupational groups
- 2005
-
Ingår i: Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 31:2, s. 138-51
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: This study examined the validity of a common belief in epidemiology with respect to work-related musculoskeletal disorders, that individual mechanical job exposure is better estimated from tasks performed in the job than from the mean exposure of the occupational group. METHODS: Whole-day recordings of upper trapezius electromyography were obtained from 24 cleaners and 23 office workers. Trapezius activity was analyzed in the level (gap time) and frequency (jerk time) dimensions. On the same day, the job of each person was divided into periods of active work and breaks by means of continuous observations. The bootstrap re-sampling technique was used with this database to compare task-based job exposure estimates with estimates based on the occupational mean. For a particular person, the task-based estimate was obtained by combining the average work and break exposures in the occupation with the personal time proportions of the two tasks in the job. RESULTS: The task-based estimates were, in general, equivalent to, or less correct than, occupation-based estimates for both exposure parameters in both occupations and for individual exposures, as well as for group means. This was the result in spite of significant and consistent exposure differences between work and breaks, in particular among the cleaners. CONCLUSIONS: Even if task exposure contrasts are large, task-based estimates of job exposures can be less correct than estimates based on the occupational mean. Since collecting and processing task information is costly, it is recommended that task-based modeling of mechanical exposure be implemented in studies only after careful examination of its possible benefits.
|
|
