| 1. |
- Nordin, Susanna, et al.
(författare)
-
Does the physical environment matter? - A qualitative study of healthcare professionals' experiences of newly built stroke units.
- 2021
-
Ingår i: International Journal of Qualitative Studies on Health and Well-being. - : Informa UK Limited. - 1748-2623 .- 1748-2631. ; 16:1
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: Organized care in specialist stroke units is fundamental for achieving better outcomes for persons with stroke. Although the importance of the physical environment for health and well-being is well recognized, research regarding how environmental features can influence stroke care is limited. The aim was to elucidate healthcare professionals' experiences of the physical environment in newly built stroke units with respect to stroke care.Methods: Healthcare professionals (n = 42) representing eight professions participated in semi-structured, face-to-face interviews. Qualitative content analysis was used.Results: The physical environment both facilitated and restricted the professionals' ability to provide stroke care. Five categories were identified: "Working towards patient engagement in single rooms", "Hampered rehabilitation in an environment not always adapted to patients' difficulties", "Addressing patients' psychosocial needs in the environment", "Ensuring patient safety by using the environment in accordance with individual needs", and "Collaboration and task fulfilment-a challenge due to care unit design".Conclusions: The healthcare professionals viewed the physical environment mainly in relation to stroke patients' specific needs, and several environmental features were considered poorly adapted to meet these needs. The physical environment is essential to high-quality care; thus, the process of planning and designing stroke units should be based on existing evidence.
|
|
| 2. |
- Allard, Christina, et al.
(författare)
-
Rasbiologiskt språkbruk i statens rättsprocess mot sameby
- 2015
-
Ingår i: Dagens Nyheter. - 1101-2447.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
|
|
| 3. |
- Ax, Anna-Karin, 1980-, et al.
(författare)
-
Cost-effectiveness of different exercise intensities during oncological treatment in the Phys-Can RCT
- 2023
-
Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 62:4, s. 414-421
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundCost-effectiveness is important in the prioritisation between interventions in health care. Exercise is cost-effective compared to usual care during oncological treatment; however, the significance of exercise intensity to the cost-effectiveness is unclear. In the present study, we aimed to evaluate the long-term cost-effectiveness of the randomised controlled trial Phys-Can, a six-month exercise programme of high (HI) or low-to-moderate intensity (LMI) during (neo)adjuvant oncological treatment.MethodsA cost-effectiveness analysis was performed, based on 189 participants with breast, colorectal, or prostate cancer (HI: n = 99 and LMI: n = 90) from the Phys-Can RCT in Sweden. Costs were estimated from a societal perspective, and included cost of the exercise intervention, health care utilisation and productivity loss. Health outcomes were assessed as quality-adjusted life-years (QALYs), using EQ-5D-5L at baseline, post intervention and 12 months after the completion of the intervention.ResultsAt 12-month follow-up after the intervention, the total cost per participant did not differ significantly between HI (€27,314) and LMI exercise (€29,788). There was no significant difference in health outcome between the intensity groups. On average HI generated 1.190 QALYs and LMI 1.185 QALYs. The mean incremental cost-effectiveness ratio indicated that HI was cost effective compared with LMI, but the uncertainty was large.ConclusionsWe conclude that HI and LMI exercise have similar costs and effects during oncological treatment. Hence, based on cost-effectiveness, we suggest that decision makers and clinicians can consider implementing both HI and LMI exercise programmes and recommend either intensity to the patients with cancer during oncological treatment to facilitate improvement of health.
|
|
| 4. |
- Ax, Anna-Karin, 1980-, et al.
(författare)
-
Long-term resource utilisation and associated costs of exercise during (neo)adjuvant oncological treatment : the Phys-Can project
- 2022
-
Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 61:7, s. 888-896
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Exercise during oncological treatment is beneficial to patient health and can counteract the side effects of treatment. Knowledge of the societal costs associated with an exercise intervention, however, is limited. The aims of the present study were to evaluate the long-term resource utilisation and societal costs of an exercise intervention conducted during (neo)adjuvant oncological treatment in a randomised control trial (RCT) versus usual care (UC), and to compare high-intensity (HI) versus low-to-moderate intensity (LMI) exercise in the RCT.METHODS: We used data from the Physical Training and Cancer (Phys-Can) project. In the RCT, 577 participants were randomised to HI or to LMI of combined endurance and resistance training for 6 months, during oncological treatment. The project also included 89 participants with UC in a longitudinal observational study. We measured at baseline and after 18 months. Resource utilisation and costs of the exercise intervention, health care, and productivity loss were compared using analyses of covariance (RCT vs. UC) and t test (HI vs. LMI).RESULTS: Complete data were available for 619 participants (RCT HI: n = 269, LMI: n = 265, and UC: n = 85). We found no difference in total societal costs between the exercise intervention groups in the RCT and UC. However, participants in the RCT had lower rates of disability pension days (p < .001), corresponding costs (p = .001), and pharmacy costs (p = .018) than the UC group. Nor did we find differences in resource utilisation or costs between HI and LMI exercise int the RCT.CONCLUSION: Our study showed no difference in total societal costs between the comprehensive exercise intervention and UC or between the exercise intensities. This suggests that exercise, with its well-documented health benefits during oncological treatment, produces neither additional costs nor savings.
|
|
| 5. |
- Broström, Markus, 1977-, et al.
(författare)
-
Sulfation of corrosive alkali chlorides by ammonium sulfate in a biomass fired CFB boiler
- 2007
-
Ingår i: Fuel processing technology. - Amsterdam : Elsevier Bv. - 0378-3820 .- 1873-7188. ; 88:11-12, s. 1171-1177
-
Tidskriftsartikel (refereegranskat)abstract
- Biomass and waste derived fuels contain relatively high amounts of alkali and chlorine, but contain very little sulfur. Combustion of such fuels can result in increased deposit formation and superheater corrosion. These problems can be reduced by using a sulfur containing additive, such as ammonium sulfate, which reacts with the alkali chlorides and forms less corrosive sulfates. Ammonium sulfate injection together with a so-called in situ alkali chloride monitor (IACM) is patented and known as "ChlorOut". IACM measures the concentrations of alkali chlorides (mainly KCl in biomass combustion) at superheater temperatures. Tests with and without spraying ammonium sulfate into the flue gases have been performed in a 96MW(th)/25MW(e) circulating fluidized bed (CFB) boiler. The boiler was fired mainly with bark and a chlorine containing waste. KCl concentration was reduced from more than 15 ppm to approximately 2 ppm. during injection of ammonium sulfate. Corrosion probe measurements indicated that both deposit formation and material loss due to corrosion were decreased using the additive. Analysis of the deposits showed significantly higher concentration of sulfur and almost no chlorine in the case with ammonium sulfate. Results from impactor measurements supported that KCl was sulfated to potassium sulfate by the additive. (C) 2007 Elsevier B.V. All rights reserved.
|
|
| 6. |
|
|
| 7. |
- Claeson, Anna-Sara, 1974-, et al.
(författare)
-
Physical and chemical trigger factors in environmental intolerance
- 2018
-
Ingår i: International journal of hygiene and environmental health. - : Elsevier. - 1438-4639 .- 1618-131X. ; 221:3, s. 586-592
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Individuals with environmental intolerance (EI) react to exposure from different environmental sources at levels tolerated by most people and that are below established toxicological and hazardous thresholds. The main aim of this study was to determine the prevalence of attributing symptoms to chemical and physical sources in the environment among individuals with different forms of self-reported EI and in referents.Methods: Cross-sectional data from a population-based study, the Västerbotten Environmental Health Study (n = 3406), were used and individuals with self-reported EI to chemicals, buildings, electromagnetic fields and sounds as well as a group with multiple EIs were identified. The Environmental-Symptom Attribution Scale was used to quantify degree to which health symptoms are attributed to 40 specific environmental exposures and sources, with subscales referring to the four types of EI.Results: All EI groups, except the group with building related intolerance (BRI), reported more symptoms from the expected sources compared to the referents. In addition, individuals with chemical and sound intolerance reported symptoms from building related trigger factors, and individuals with electromagnetic hypersensitivity reported symptoms from chemical trigger factors.Conclusions: The study suggests that individuals with BRI react to fewer and more specific trigger factors than do individuals with other EIs, and that it is important to ask about different sources since three of the EI groups attribute their symptoms to a wide variety of sources in addition to the sources to which their EI implicates.
|
|
| 8. |
- Forsman, Huamei, et al.
(författare)
-
Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library.
- 2011
-
Ingår i: Biochemical pharmacology. - : Elsevier BV. - 1873-2968 .- 0006-2952. ; 81:3, s. 402-411
-
Tidskriftsartikel (refereegranskat)abstract
- The neutrophil formyl peptide receptors (FPR1 and FPR2) are G-protein coupled receptors that can induce pro-inflammatory as well as anti-inflammatory activities when activated. Accordingly, these receptors may become therapeutic targets for the development of novel drugs to be used for reducing the inflammation induced injuries in asthma, rheumatoid arthritis, Alzheimer's disease, cardiovascular diseases and traumatic shock. We screened a library of more then 50K small compounds for an ability of the compounds to induce a transient rise in intracellular Ca(2+) in cells transfected to express FPR2 (earlier called FPRL1 or the lipoxin A(4) receptor). Ten agonist hits were selected for further analysis representing different chemical series and five new together with five earlier described molecules were further profiled. Compounds 1-10 gave rise to a calcium response in the FPR2 transfectants with EC(50) values ranging from 4×10(-9)M to 2×10(-7)M. All 10 compounds activated human neutrophils to release superoxide, and based on the potency of their activity, the three most potent activators of the neutrophil NADPH-oxidase were further characterized. These three agonists were largely resistant to inactivation by neutrophil produced reactive oxygen species and shown to trigger the same functional repertoire in neutrophils as earlier described peptide agonists. Accordingly they induced chemotaxis, granule mobilization and secretion of superoxide. Interestingly, the oxidase activity was largely inhibited by cyclosporine H, an FPR1 selective antagonist, but not by PBP10, an FPR2 selective inhibitor, suggesting that FPR1 is the preferred receptor in neutrophils for all three agonists.
|
|
| 9. |
- Henriksson, Anna, 1983-, et al.
(författare)
-
Exploring lived experience of sedentary behavior during cancer treatment : - a phenomenological study
- 2021
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background Sedentary behavior (SB) increases during cancer treatment, which may have deteriorating effects on long-term health. Few studies exploring patients' experience of SB during neo- or adjuvant cancer treatment have been conducted, and this information may be crucial in developing effective support for patients to reduce SB.Purpose To explore the lived experiences of SB in patients undergoing neo- or adjuvant cancer treatment and to explore the impact of the COVID-19 pandemic.MethodsIndividual interviews were conducted with patients undergoing treatment for breast, prostate and colorectal cancer recruited from the oncological department of a university hospital in Sweden. Interviews were analyzed phenomenologically and results presented as descriptions of the phenomenon SB. Results Preliminary results are that patients describe SB by depicting physical activity and awareness of its health benefits. Also, being inactive or sedentary is stigmatized. The type and phase of treatment, life circumstances (COVID-19 pandemic, sick leave) as well as motivation, social support, and self-image can impact SB during treatment.Conclusions The results indicate that SB is difficult for patients to discern. This suggests that SB is an unimplemented concept in the cancer context and needs to be addressed in a way that does not stigmatize patients. The coronavirus pandemic had both negative and positive impacts on SB for these patients. Furthermore, developing support that targets periods with more side-effects and helping patients reduce SB throughout changed life circumstances may be helpful.
|
|
| 10. |
- Lind, Nina, 1989-, et al.
(författare)
-
Comorbidity and multimorbidity of asthma and allergy and intolerance to chemicals and certain buildings
- 2017
-
Ingår i: Journal of Occupational and Environmental Medicine. - 1076-2752 .- 1536-5948. ; 59:1, s. 80-84
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: We tested the hypothesis of high comorbidity between asthma/allergy and chemical intolerance (CI) and between asthma/allergy and building intolerance (BI), and high multimorbidity between asthma/allergy, CI, and BI.Methods: Population-based questionnaire data were used from 530 participants with asthma/allergy (allergic asthma, nonallergic asthma, allergic rhinitis, and/or atopic dermatitis), 414 with self-reported and 112 with physician-diagnosed CI, and 165 with self-reported and 47 with physician-diagnosed BI. Separate reference groups were formed for each of the five case groups.Results: Adjusted odds ratios varied from 4.6 to 13.1 for comorbidity, and from 6.6 to 46.4 for multimorbidity.Conclusion: The large comorbidity and multimorbidity between asthma/allergy, CI, and BI evokes the question as to whether there are similarities in underlying mechanisms between these conditions.
|
|
