| 1. |
- Allard, Christina, et al.
(författare)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby
- 2015
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Ingår i: Dagens Nyheter. - 1101-2447.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 2. |
- Allard, Christina, et al.
(författare)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby : DN Debatt 2015-06-11
- 2015
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Annan publikation (populärvet., debatt m.m.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 3. |
- Carlsson, Björn, et al.
(författare)
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Enantioselective Analysis of Citalopram and Metabolites in Adolescents
- 2001
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Ingår i: Therapeutic drug monitoring. - : Ovid Technologies (Wolters Kluwer Health). - 0163-4356. ; 23, s. 658-
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Tidskriftsartikel (refereegranskat)abstract
- Studies of the antidepressant effect and pharmacokinetics of citalopram have been performed in adults, but the effects on children and adolescents have only been studied to a minor extent despite its increasing use in these age groups. The aim of this study was to investigate a group of adolescents treated for depression, with respect to the steady-state plasma concentrations of the enantiomers of citalopram and its demethylated metabolites desmethylcitalopram and didesmethylcitalopram. Moreover, the authors studied the genotypes for the polymorphic cytochrome P450 enzymes CYP2D6 and CYP2C19 in relation to the different enantiomers. The S/R ratios of citalopram and desmethylcitalopram found in this study of 19 adolescents were similar to studies involving older patients. The concentrations of the R-(-)- and S-(+)-enantiomers of citalopram and desmethylcitalopram were also in agreement with values from earlier studies, the R-(-)-enantiomer (distomer) being the major enantiomer. The results indicate that the use of oral contraceptives may have some influence on the metabolism of citalopram. This might be because of an interaction of the contraceptive hormones with the CYP2C19 enzyme.
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| 4. |
- Carson, Dean B., et al.
(författare)
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Lessons from the Arctic past : The resource cycle, hydro energy development, and the human geography of Jokkmokk, Sweden
- 2016
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Ingår i: Energy Research & Social Science. - : Elsevier BV. - 2214-6296 .- 2214-6326. ; 16, s. 13-24
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Tidskriftsartikel (refereegranskat)abstract
- Recent research has identified a series of human geography impacts of natural resource developments in sparsely populated areas like the Arctic. These impacts can be mapped to the 'resource cycle', and arise from periods of population growth and decline, changing patterns of human migration and mobility, changing patterns of settlement, and changes in the demographic 'balance' between males and females, young and old, Indigenous and non-Indigenous. This paper examines the applicability of the resource cycle model in the case of hydro energy development in the Jokkmokk municipality of Sweden. Using quantitative demographic data, media reports, and contemporary accounts of hydro development, the paper describes the human geography of Jokkmokk since the late 19th century. The paper concludes that changes in human geography in Jokkmokk mirror what has been observed in regions dependent on non-renewable resources, although it is difficult to distinguish many impacts from those that might have occurred under alternative development scenarios. The paper identifies a 'settlement cycle' with phases of integrated and separated habitation for populations specifically associated with the development. Settlement dynamics, and the impacts of hydro on Sami geography are areas for further research.
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| 5. |
- Gorlova, Olga, et al.
(författare)
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Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy
- 2011
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 7:7
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (IcSSc) and diffuse (dcSSc) cutaneous involvement, and the relationships with presence of the SSc-specific auto-antibodies, anti-centromere (ACA), and anti-topoisomerase I (ATA). Four GWAS cohorts, comprising 2,296 SSc patients and 5,171 healthy controls, were meta-analyzed looking for associations in the selected subgroups. Eighteen polymorphisms were further tested in nine independent cohorts comprising an additional 3,175 SSc patients and 4,971 controls. Conditional analysis for associated SNPs in the HLA region was performed to explore their independent association in antibody subgroups. Overall analysis showed that non-HLA polymorphism rs11642873 in IRF8 gene to be associated at GWAS level with lcSSc (P = 2.32x10(-12), OR = 0.75). Also, rs12540874 in GRB10 gene (P = 1.27 x 10(-6), OR = 1.15) and rs11047102 in SOX5 gene (P = 1.39x10(-7), OR = 1.36) showed a suggestive association with lcSSc and ACA subgroups respectively. In the HLA region, we observed highly associated allelic combinations in the HLA-DQB1 locus with ACA (P = 1.79x10(-61), OR = 2.48), in the HLA-DPA1/B1 loci with ATA (P = 4.57x10(-76), OR = 8.84), and in NOTCH4 with ACA P = 8.84x10(-21), OR = 0.55) and ATA (P = 1.14x10(-8), OR = 0.54). We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and autoantibody subgroups. Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc.
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| 6. |
- López-Isac, Elena, et al.
(författare)
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Brief Report : IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies
- 2016
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Ingår i: Arthritis & Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 68:9, s. 2338-2344
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome-wide association (meta-GWAS) strategy. Methods: The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case–control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls. Results: This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P < 5 × 10−6) that also showed evidence of association in the disease-specific GWAS scans. These loci included several genomic regions not previously reported as shared loci, as well as several risk factors that were previously found to be associated with both diseases. Follow-up analyses of the putatively new SSc–RA loci identified IRF4 as a shared risk factor for these 2 diseases (Pcombined = 3.29 × 10−12). Analysis of the biologic relevance of the known SSc–RA shared loci identified the type I interferon and interleukin-12 signaling pathways as the main common etiologic factors. Conclusion: This study identified a novel shared locus, IRF4, for the risk of SSc and RA, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci.
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| 7. |
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| 8. |
- Nordin, Gabriella, 1970-
(författare)
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Adopting or Rejecting a New Culture? : Marriage patterns among settled Sami under impact of the colonization process in 19th Century Northern Sweden.
- 2010
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Ingår i: <em></em>.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The predominant inhabitants in the northern Sweden were until the beginning of 19th century the Sami people, indigenous and often nomadic reindeer breeders. As the colonization process of the northern part of the country progressed, it led to increasing contacts between Sami people and Swedes. To some extent there were also Sami people who settled down, chiefly from the forest Sami group, but the majority of the settlers where newcomers. Although previous historical research has focused on the nomadic Sami people, those settled have so far attracted less attention about their demographic behaviour. Knowing their marriage pattern helps illuminate what happens when people from different cultures meet; did the cultural and social grounds shift? And further, did the marriage behaviour among Sami people change when they settled down? Did the Sami people who settled down adopt Swedish cultural grounds or were they more inclined to follow their old traditions and marry within their own group? The main purpose of this paper is thus to explore whether a settled life affected the way Sami people chose to make decisions of decisive importance, in this paper represented by the way people chose whom and when to marry? To meet the aim of this analysis world unique parish registers stored at the Demographic Data Base (DDB), Umeå University are utilized.
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| 9. |
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| 10. |
- Nordin, Gabriella, 1970-
(författare)
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Familjelivet
- 2016
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Ingår i: Samiska rötter. - : Sveriges släktforskarförbund. - 9789188341037 ; , s. 117-126
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Bokkapitel (populärvet., debatt m.m.)
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