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| 2. |
- Fritzson, Dag, et al.
(författare)
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Adaptive scheduling strategy optimizer for parallel rolling bearing simulation
- 1999
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Ingår i: High-Performance Computing and Networking. - : Springer Berlin/Heidelberg. - 3540658211 - 9783540658214 - 9783540489337 ; , s. 99-108
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Bokkapitel (refereegranskat)abstract
- Rolling bearing simulations are very computationally intensive and need to utilize the potential of parallel computing. The load distribution over the processors in a rolling bearing simulation is very dynamic. In this paper we present the Adaptive Scheduling Strategy Optimizer (ASSO) for scheduling parallel simulations. The result of this is that the application can automatically select a near optimal scheduling strategy (with respect to the available scheduling strategies). The ASSO is used daily in real bearing simulations.
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| 3. |
- Fritzson, Dag, et al.
(författare)
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Rolling Bearing Simulation on MIMD Computers
- 1997
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Ingår i: The international journal of high performance computing applications. - : Sage Publications. - 1094-3420 .- 1741-2846. ; 11:4, s. 299-313
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Tidskriftsartikel (refereegranskat)abstract
- Rolling bearing simulations are very computationally in tensive. Serial simulations may take weeks to execute, and there is a need to use the potential of parallel comput ing. The specific structure of the rolling bearing problem is used to develop suitable scheduling strategies. The authors discuss the system of stiff ordinary differential equations arising from a bearing model and show how to numerically solve these ordinary differential equations on parallel computers. Benchmarking results are presented for two test cases on three platforms.
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| 4. |
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| 5. |
- Nordling, Patrik, et al.
(författare)
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Parallelization of the CVODE ordinary differential equation solver with applications to rolling bearing simulation
- 1995
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Ingår i: High-Performance Computing and Networking. - : Springer.
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Konferensbidrag (refereegranskat)abstract
- We discuss how to solve ordinary differential equations on parallel computers, with application to dynamic rolling bearing simulation. We show how to parallelize both the solver and the model, in order to get a scalable application. The obtained results show that, within the original CVODE solver, LU factorization and the forward/backward elimination of the Newton matrix, for the rolling bearing application can be done in almost constant time, independent of the problem size.
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| 6. |
- Nordling, Patrik, et al.
(författare)
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Rolling Bearing Simulation On Mimd Computers
- 1996
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Konferensbidrag (refereegranskat)abstract
- Rolling bearing simulations are very computationally in tensive. Serial simulations may take weeks to execute, and there is a need to use the potential of parallel comput ing. The specific structure of the rolling bearing problem is used to develop suitable scheduling strategies. The authors discuss the system of stiff ordinary differential equations arising from a bearing model and show how to numerically solve these ordinary differential equations on parallel computers. Benchmarking results are presented for two test cases on three platforms.
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| 7. |
- Nordling, Patrik, et al.
(författare)
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Solving ordinary differential equations on parallel computers — applied to dynamic rolling bearings simulation
- 1994
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Ingår i: Parallel Scientific Computing. - : Springer Berlin/Heidelberg. - 9783540587125 - 9783540490500 ; , s. 397-415
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Konferensbidrag (refereegranskat)abstract
- In this paper we investigate how to solve certain kinds of ordinary differential equations (ODEs) efficiently on several types of MIMD parallel computers. The amount of parallelism for solving initial value problems such as ODEs is often quite limited, but by exploiting some characteristics of the application area where these problems are solved, the amount of parallelism can be increased. We focus on solving ODEs for rolling bearing dynamics simulation, which is computationally expensive. Typical characteristics of such ODEs are: stiff ODEs, very high numerical precision needed for solution, and computationally expensive to evaluate the derivatives.We have adapted conventional solvers such as LSODA for execution on parallel computers, for example by evaluating the right-hand sides of the ODEs in parallel. The parallel machines used are: a Parsytec GigaCube with 16 T805 processors using the PARIX operating system, a Sun SPARCcenter 2000 with 8 processors and Solaris 2.3, and a cluster of nine SPARC 10 workstations connected via ethernet and using PVM. All these can be considered as Multiple Instruction Multiple Data (MIMD) architectures.The obtained speedup was fairly good, approximately two thirds of linear speedup. However, this application requires rather fine-grained synchronization, which favours scheduling methods that minimize communication. As always, it is easier to get good speedups on machines with slower processors
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| 8. |
- Volk, Anna-Luisa, et al.
(författare)
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Stratification of responders towards eculizumab using a structural epitope mapping strategy
- 2016
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- The complement component 5 (C5)-binding antibody eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS). As recently reported there is a need for a precise classification of eculizumab responsive patients to allow for a safe and cost-effective treatment. To allow for such stratification, knowledge of the precise binding site of the drug on its target is crucial. Using a structural epitope mapping strategy based on bacterial surface display, flow cytometric sorting and validation via haemolytic activity testing, we identified six residues essential for binding of eculizumab to C5. This epitope co-localizes with the contact area recently identified by crystallography and includes positions in C5 mutated in non-responders. The identified epitope also includes residue W917, which is unique for human C5 and explains the observed lack of cross-reactivity for eculizumab with other primates. We could demonstrate that Ornithodorus moubata complement inhibitor (OmCI), in contrast to eculizumab, maintained anti-haemolytic function for mutations in any of the six epitope residues, thus representing a possible alternative treatment for patients non-responsive to eculizumab. The method for stratification of patients described here allows for precision medicine and should be applicable to several other diseases and therapeutics.
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