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| 2. |
- Akkermann, Kirsti, et al.
(författare)
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Association of 5-HTT gene polymorphism, platelet MAO activity, and drive for thinness in a population-based sample of adolescent girls
- 2008
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Ingår i: International Journal of Eating Disorders. - : Wiley. - 0276-3478 .- 1098-108X. ; 41:5, s. 399-404
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Several lines of evidence suggest that alterations in serotonergic activity contribute to the pathophysiology of abnormal eating behaviors. Since platelet monoamine oxidase (MAO) activity and the 5-HT transporter gene promoter polymorphism (5-HTTLPR) have been associated with eating disorders, the knowledge from a population-based sample may provide useful information which changes in 5-HT function observed in eating disorders represent trait vs. state effects. METHOD: The sample was based on both cohorts of the Estonian Children Personality, Behavior and Health Study (ECPBHS). The current study was conducted during the second follow-up where altogether 82% from the original sample was recruited. EDI-2 subscales--Drive for Thinness and Bulimia--were used to determine eating attitudes and behaviors. Platelet MAO activity was measured and the participants were genotyped for the 5-HTTLPR. RESULTS: Allelic variation of 5-HTTLPR or platelet MAO activity were not independently associated with drive for thinness or binge eating, but girls homozygous for the 5-HTTLPR long allele and with high platelet MAO activity, both considered indicators of a higher capacity 5-HT system, exhibited higher scores of drive for thinness. CONCLUSION: The results suggest that drive for thinness is the highest in girls with the presence of two markers of higher serotonergic capacity.
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| 3. |
- Akkermann, Kirsti, et al.
(författare)
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Serotonin transporter gene promoter polymorphism affects the severity of binge eating in general population
- 2010
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Ingår i: Progress in Neuro-psychopharmacology and Biological Psychiatry. - : Elsevier BV. - 0278-5846 .- 1878-4216. ; 34:1, s. 111-114
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Forskningsöversikt (refereegranskat)abstract
- Objective: The s-allele of the 5-HTTLPR has been suggested to lead to the development of less efficient and less flexible 5-HT system and has been associated to different forms of psychopathology. It has also been shown that alterations in serotonergic activity contribute to the pathophysiology of binge eating but it is not clear which changes in 5-HT function observed in eating disorder patients represent trait vs state effect. We investigated the association between the 5-HTTLPR and binge eating in a population-representative sample of women, and tested whether the 5-HTTLPR genotype influences the severity of binge eating. Methods: The sample was based on women participating in the third wave of the Estonian Children Personality, Behaviour and Health Study. EDI-2 subscales - drive for thinness and bulimia - were used to assess eating behaviour and attitudes. Barratt Impulsiveness Scale (BIS-11) and State and Trait Anxiety Inventory (STAI) were used to measure impulsivity and anxiety. Participants were genotyped for the 5-HTTLPR. Results: There was no 5-HTTLPR genotype effect on binge eating even after the covarying effect of impulsivity and anxiety was controlled for. However, women prone to binge eating and carrying the s-allele showed significantly higher levels of bulimia scores, and among them, women with s/s genotype had also higher levels of state anxiety and tendency for higher impulsivity. Conclusions: While the 5-HTTLPR genotype does not predict symptoms of eating disorder in general population, the s-allele, and especially the s/s genotype increases the risk for affective instability and symptom severity.
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| 4. |
- Akkermann, Kirsti, et al.
(författare)
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The impact of adverse life events and the serotonin transporter gene promoter polymorphism on the development of eating disorder symptoms
- 2012
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Ingår i: Journal of Psychiatric Research. - : Elsevier BV. - 0022-3956 .- 1879-1379. ; 46:1, s. 38-43
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Tidskriftsartikel (refereegranskat)abstract
- Adverse life events have been shown to predict weight fluctuations and dietary restraint, as well as eating disorders during adolescence or early adulthood. Since the s-allele carriers of the 5-HTT gene-linked polymorphic region (5-HTTLPR) are biologically more reactive to stress related stimuli, we aimed to explore whether the eating disturbances are predicted by environmental stressors and moderated by the 5-HTTLPR genotype. The sample was based on the younger cohort of the Estonian Children Personality, Behaviour and Health Study and included those participating in its second and third wave. The history of stressful life events was self-reported at age 15. Data on eating behaviour and attitudes, anxiety, impulsivity and depressiveness were collected at age 18. The effect of the adverse life events on binge eating and on drive for thinness was found to be moderated by the 5-HTTLPR. Adolescent girls who at age 15 had reported a history of frequent adverse life events had elevated scores in EDI-2 Bulimia subscale at age 18 if they were carrying the s-allele. The effect of the s-allele on binge eating was even more pronounced when solely the experience of sexual abuse was considered. The interaction effect of the 5-HTTLPR and the past sexual abuse was also observed on drive, for thinness. These data give further support to the idea that adverse life events in childhood may heighten susceptibility to serotonergic dysregulation following stress, and suggest that in individuals vulnerable to eating disorders this may result in disturbed eating behaviours.
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| 7. |
- Bergstrand, Anna, et al.
(författare)
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Samverkansmeritering - förutsättningar, behov och möjligheter : Rapport: MERSAM-Meritvärde av samverkansskicklighet
- 2021
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Rapport (populärvet., debatt m.m.)abstract
- Samverkansuppgiften har gradvis fått en tydligare roll sedan mitten av 1990-talet och är idag en nödvändig och central uppgift för högskolor och universitet i Sverige, inte minst för att hantera vår tids samhällsutmaningar. Det finns få tecken på att denna utveckling kommer att vända och det är därför viktigt att vi inom sektorn för en dialog kring hur vi tar oss an och värderar det arbete som sker inom ramen för samverkansuppgiften. Det är troligt att vi i sektorn även en tid framöver kommer att diskutera hur samverkansuppgiften bör tolkas och samverkansmeriter värderas, men det hindrar oss inte att på allvar försöka stödja och strukturera det arbete som redan sker dagligen vid landets lärosäten.Projektets bidrag är att belysa ett antal observationer kring utmaningar inom sektorn, för våra lärosäten och individer men också visa på möjligheter för våra lärosäten genom att ta upp några tänkbara verktyg, arbetssätt och rekommendationer för utveckling av samverkansmeritering.Huvudbudskapen i denna rapport är att sektorn behöver skapa en tydligare och mer preciserad begreppsbildning relaterat till ”samverkan” och samverkansmeriter. Lärosätena behöver utveckla ett mer integrerat och strukturerat sätt att arbeta med samverkansmeriter genom hela rekrytering- och befordringsprocessen, då förståelse av samverkansmeriter och praxis fortfarande är underutvecklat. Lärosätena behöver vidare utveckla stöd för forskare och lärare i att kunna sammanställa och dokumentera samverkansmeriter, separat eller integrerat med övriga meriter. En verkningsfull, flerspråkig begreppsapparat och förståelse men även efterfrågan på samverkansmeriter behöver utvecklas gemensamt av sektorns alla aktörer och vid varje lärosäte.Rapporten riktar sig i första hand till två målgrupper:1.Personer och funktioner vid lärosäten som har ansvar för eller leder utvecklingsarbete kopplat till meritering och kompetensförsörjning på olika nivåer (dekaner, utvecklingsledare, HR specialister, ordförande i rekryteringskommittéer eller motsvarande samt olika former av samverkansstöd). För dessa innehåller rapporten resonemang, rekommendationer och konkreta verktyg som kan användas som utgångspunkt för dialog och utveckling av samverkansmeritering vid lärosäten.2.Ledningsfunktioner vid lärosäten, myndigheter samt sektorsintressenter. För dessa kan rapporten ge ökad kunskap om tillståndet för samverkansmeritering vid svenska lärosäten och insikter om möjligheter för utveckling.Projektet har tagit fram ett utbildningsmaterial för att stödja fortsatt utvecklingsarbete på olika nivåer vid lärosäten samt en vägledning för att dokumentera och beskriva samverkansmeriter. Vägledningen kan användas för inspiration till lärare och forskare som vill sammanställa sina samverkansmeriter. De verktyg som presenteras i vägledningen kan också användas vid kompetensplanering, bedömningssituationer och medarbetarsamtal.Förhoppningen är att MerSam-projektet och denna rapport, dialog inom och mellan lärosäten samt mellan lärosäten och sektorsintressenter, bidrar till fortsatt utveckling av samverkansmeritering samt till att skapa en gemensam uppfattning om vad det betyder att meritera sig inom ramen för samverkansuppgiften.
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| 8. |
- Comasco, Erika, et al.
(författare)
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Adolescent alcohol consumption : Biomarkers PEth and FAEE in relation to interview and questionnaire data
- 2009
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Ingår i: Journal of Studies on Alcohol and Drugs. - : ALCOHOL RES DOCUMENTATION INC CENT ALCOHOL STUD RUTGERS UNIV. - 1937-1888 .- 1938-4114. ; 70:5, s. 797-804
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE The aim of this study was to investigate the congruence of biomarkers, questionnaires, and interviews as instruments to assess adolescent alcohol consumption. METHOD The methodology used was a cross-sectional study with a randomized sample. Four different methods were used to estimate high adolescent alcohol consumption. The concordance of the results was investigated. Surveys were performed, and biological specimens were collected at all schools in the county of Västmanland, Sweden, in 2001. Eighty-one boys and 119 girls from a population of 16- and 19-year-old adolescents were randomly selected from quartiles of volunteers representing various degrees of psychosocial risk behaviors. Using a questionnaire (for a 1-hour session) and in-depth interviews, subjects were assessed regarding their alcohol-use habits. Blood and hair samples were analyzed for phosphatidylethanol (PEth) and fatty acid ethyl esters (FAEEs), respectively. RESULTS High alcohol consumption was underreported in the questionnaire compared with the interviews. PEth and FAEE analyses weakly confirmed the self-reports, and the results of the two biochemical tests did not overlap. The PEth blood test was the most specific but the least sensitive, whereas the FAEE hair test revealed low specificity and an overrepresentation of positive results in girls. CONCLUSIONS The expected higher self-report of high alcohol consumption by interview rather than by questionnaire was confirmed partly because of the influence of a bogus pipeline procedure. The absence of overlap between PEth and FAEE results and their poor agreement with self-reports suggested that biomarkers are unsuitable as screening tools for alcohol consumption in adolescents.
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| 9. |
- Comasco, Erika, et al.
(författare)
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The clock gene PER2 and sleep problems : association with alcohol consumption among Swedish adolescents
- 2010
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Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 115:1, s. 41-48
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Alcohol abuse is associated with sleep problems, which are often linked to circadian rhythm disturbances. Previous studies have separately examined the effects of mutations in the clock gene PER2 on alcohol consumption and sleep problems. Here we hypothesized that an allelic variation in the PER2 gene is associated with alcohol consumption in interaction with sleep problems among adolescents. METHODS: The Survey of Adolescent Life and Health in Västmanland 2006, a Swedish county, including 1254 students 17-18 years old, was used as a population-representative sample of adolescents. We investigated the PER2 Single Nucleotide polymorphism (SNP) 10870 (A/G) in the cohort together with an assessment of alcohol consumption according to the AUDIT-C questionnaire, and sleep problems using a survey consisting of 18 items. Furthermore, we carried out an exploratory analysis on the PER2 Single Nucleotide Polymorphism 10870 polymorphism in a group of severely alcoholic females. RESULTS: We found a significant association of the SNP 10870 in adolescent boys, where the genotype AA, in the presence of several and frequent sleep problems, was associated with increased alcohol consumption. Among adolescent girls, only sleep problems were related to alcohol consumption. A non-significant trend was observed among the severely alcoholic females, with the G allele being over-represented in the severely alcoholic females group in comparision to the control females. CONCLUSION: These results indicate that PER2 gene variation is associated with alcohol consumption in interaction with sleep problems among Swedish adolescent boys.
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| 10. |
- Ejdesjö, Andreas, 1978-
(författare)
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Teratogenic Predisposition in Diabetic Rat Pregnancy
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Pre-gestational diabetes increases the risk of congenital malformation in the offspring and both morbidity and mortality in the diabetic mother and her offspring. During pregnancy, high glucose levels act as a teratogen through several cellular and biochemical pathways and increased production of reactive oxygen species (ROS) has a central role in diabetic embryopathy. The aim of this work was to investigate the importance of genetic predisposition for congenital malformations and to study the genes involved in the teratogenic process of diabetic pregnancy.The crossbreeding of two rat strains, with both low and high incidence of diabetes-induced malformations, indicated that strain-specific maternal factors, such as disturbed serum levels of amino acids, triglycerides, and β-hydroxybutyrate, were associated with malformation. In addition, disturbed fetal expression of genes involved in ROS defense and development (Shh, Bmp4, Ret and Gdnf) in mandible and heart, and decreased activity of Gapdh and Aldose Reductase were associated with the teratogenic process, and the trans-generational heredity of the mother determined the type of malformations induced by maternal diabetes.In rat embryos, a diabetic environment in utero changed the expression of genes involved in ROS defense (Nrf2, Gpx1 and Cat), development of mandible and heart (Msx2, Shh, Bmp4, Ret and Gdnf), and neural tube closure and apoptosis (Pax3 and p53). The changes were divergent with tissue-specific alterations of gene expression in developing mandible, heart anlage, and whole embryo.Disruption of the Receptor for Advanced Glycation End products (RAGE) had a protective effect against diabetic embryopathy in mice, and the blockage of RAGE diminished ROS production in the offspring: this supported oxidative stress being a necessary etiological component in diabetic embryopathy.Maternal metabolic state and genetic susceptibility influence fetal outcome in experimental diabetic pregnancy. Disturbed protection against oxidative stress and tissue-specific derangements in the expression of developmental genes play pivotal roles in the teratogenic mechanism, and enhanced levels of Advanced Glycation End products (AGE) and RAGE-induced oxidative stress are involved in diabetic dysmorphogenesis.
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