| 1. |
- Ackum, Susanne, et al.
(författare)
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Vi tar fram en handfast plan för en omstart av Sverige
- 2020
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Ingår i: Dagens Nyheter. - 1101-2447. ; :27 april
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Det är /.../ fullt möjligt att tänka strategiskt och systematiskt även i brinnande kris. Omstartskommissionen hoppas kunna bidra till fokus, analys och konkreta policyförslag för att stödja Sveriges långsiktiga inriktning. Vi kommer att under våren och sommaren anordna seminarier och hearings om vårt arbete, delrapporter ska läggas fram – och när budgetarbetet börjar och Riksdagen öppnar, vill vi kunna bidra med en rejäl och handfast plan för hur vi omstartar Sverige.
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| 2. |
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| 3. |
- Braunerhjelm, Pontus, 1953-, et al.
(författare)
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Så startar Sverige om
- 2020
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Annan publikation (populärvet., debatt m.m.)
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| 4. |
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| 5. |
- Ghaderi Aram, Morteza, 1988, et al.
(författare)
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Radiobiological modeling of hyperthermia combined with Gamma-Knife radiosurgery in pediatric brain cancer
- 2021
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Assessment of the synergistic effect of radiotherapy (RT) and hyperthermia (HT) in clinical settings is crucial for further expansion of hyperthermia. The radiobiological modeling using an extended version of the LQ model with temperature-dependent radiosensitivity parameters has been suggested in combination with external beam radiotherapy in previous studies. This study investigates the radiobiological effect of intracranial hyperthermia combined with stereotactic radiosurgery (SRS) in pediatric brain cancers. The hyperthermia treatment plan was achieved with an elliptical applicator consisting of 16 ORWG antennas working at 400 MHz and a hybrid Specific Absorption Rate (SAR) optimization procedure based on Time-Reversal and PSO. The radiotherapy plan was created by the treatment planning software of Leksell Gamma Knife® Icon™.
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| 6. |
- Neumann, Nicole G., 1979-
(författare)
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The paralemmin protein family : Phosphoproteins involved in filopodia and dendritic spine formation
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Dendritic spines, which connect neurons with each other, constitute most of the excitatory synapses and undergo experience-dependent neuronal plasticity. The function of dendritic spines and their synaptic strength are highly correlated with morphological changes. Remodeling of the nervous system in terms of establishment, maintenance, and organized elimination of dendritic spines is important during neuronal development, and for learning and memory. Pathological alterations in dendritic spine morphology, number and plasticity have been associated with many neurodegenerative disorders. However, the underlying molecular mechanisms are still poorly understood. Paralemmin-1 has been shown to play a key role in spine formation through the regulation of filopodia formation. Furthermore, because paralemmin-1 is post-translationally modified it harbors the potential of serving as a spine morphology regulatory protein. Here, we have investigated the role of the paralemmin-1 spanning from molecule to whole organism. We found that all paralemmin family members, paralemmin-1, palmdelphin, paralemmin-2 and paralemmin-3, are associated with filopodia formation in young hippocampal neurons, are strongly expressed in the brain and share molecular features: (i) general gene architecture, (ii) the COOH-terminal CaaX-box lipidation motif, which anchors them to the plasma membrane, (iii) the predicted coiled-coil structure motif at the NH2-terminus and (iv) the prediction to be – in large parts – intrinsic disordered proteins. The investigation of paralemmin-1 knockout mice showed that they are fertile, survive to high age and have two mild phenotypes: impaired motor coordination in males and a tendency for obesity in females. The neuron morphology was not altered in paralemmin-1 knockout hippocampal neurons. The protein expression level of palmdelphin, paralemmin-2, and paralemmin-3 was not affected in paralemmin-1 knockout mice. However, functional redundancy of the paralemmins may mask stronger phenotypes in paralemmin-1 knockout mice. Acute knockout of Paralemmin-1 in cultured conditional hippocampal neurons revealed a decrease in the number of filopodia and dendritic spines. Paralemmin-1 and palmdelphin are highly phosphorylated, with most phosphorylation sites identified in the brain. Mutation of eight phosphorylation sites of paralemmin-1 to amino acids mimicking the nonphosphorylated state resulted in fewer mushroom-shaped dendritic spines in cultured hippocampal neurons. Our findings underscore the importance of regulation through phosphorylation in the development and function of the nervous system. Additionally, we present the first evidence that the paralemmins might be intrinsically disordered proteins, which may provide novel routes of protein regulation and interaction.
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| 7. |
- Norbäck, Dan, et al.
(författare)
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Carbon dioxide (CO2) demand-controlled ventilation in university computer classrooms and possible effects on headache, fatigue and perceived indoor environment : an intervention study
- 2013
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Ingår i: International Archives of Occupational and Environmental Health. - : Springer Science and Business Media LLC. - 0340-0131 .- 1432-1246. ; 86:2, s. 199-209
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Tidskriftsartikel (refereegranskat)abstract
- PurposeTo study the effects of a CO2 demand-controlled ventilation system (variable flow) in computer classrooms on perceived air quality and sick building syndrome.MethodsUniversity students (27 % women) participated in a blinded study. Two classrooms had variable flow (mean 5.56 ac/h); two others had constant ventilation flow (mean 5.07 ac/h). After one week, ventilation conditions were shifted. The students reported symptoms/perceptions during the last hour on rating scales. Temperature, air humidity, CO2, PM10 and number concentration of particles were measured simultaneously. Cat (Fel d 1), dog (Can f 1), horse (Equ cx) and house dust mites (Der f 1 and Der p 1) allergens were measured in dust. Those participating twice in the same classroom (N = 61) were analysed longitudinally.ResultsMean CO2 was 784 ppm (9 % of time >1,000 ppm) with variable flow and 809 ppm with constant flow conditions (25 % of time >1,000 ppm). Mean temperature (22.6 °C), PM10 (18 μg/m3) and number concentration (1,860 pt/cm3) were unchanged. The median levels of cat, dog, horse and Der f 1 allergens were 10,400 ng/g, 4,900 ng/g, 13,700 U/ng and 260 ng/g dust, respectively. There were slightly less headache (p = 0.003), tiredness (p = 0.007) and improved perceived air quality (p = 0.02) with variable flow.ConclusionsUse of a CO2-controlled ventilation system, reducing elevated levels of CO2, may slightly reduce headache and tiredness and improve perceived air quality. The high levels of pet allergens, due to track in of allergens from the home and possible accumulation due to electrostatic forces, illustrate a need for improved cleaning.
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| 8. |
- Norbäck, Dan, et al.
(författare)
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Sick building syndrome in relation to air exchange rate, CO(2), room temperature and relative air humidity in university computer classrooms : an experimental study
- 2008
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Ingår i: International Archives of Occupational and Environmental Health. - : Springer Science and Business Media LLC. - 0340-0131 .- 1432-1246. ; 82:1, s. 21-30
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study the effects of ventilation and temperature changes in computer classrooms on symptoms in students. METHODS: Technical university students participated in a blinded study. Two classrooms had higher air exchange (4.1-5.2 ac/h); two others had lower (2.3-2.6 ac/h) air exchange. After 1 week, ventilation conditions were interchanged between the rooms. The students reported symptoms during the last hour, on a seven-step rating scale. Room temperature, relative air humidity (RH) carbon dioxide (CO(2)), PM10 and ultra-fine particles (UFP) were measured simultaneously (1 h). Illumination, air velocity, operative temperature, supply air temperature, formaldehyde, NO(2) and O(3) were measured. Multiple logistic regression was applied in cross-sectional analysis of the first answer (N = 355). Those participating twice (N = 121) were analysed longitudinally. RESULTS: Totally 31% were females, 2.9% smokers and 3.8% had asthma. Mean CO(2) was 993 ppm (674-1,450 ppm), temperature 22.7 degrees C (20-25 degrees C) and RH 24% (19-35%). Lower and higher air exchange rates corresponded to a personal outdoor airflow of 7 l/s*p and 10-13 L/s*P, respectively. Mean PM10 was 20 mug/m(3) at lower and 15 mug/m(3) at higher ventilation flow. Ocular, nasal and throat symptoms, breathlessness, headache and tiredness were significantly more common at higher CO(2) and temperature. After mutual adjustment, ocular (OR = 1.52 per 1 degrees C), nasal (OR = 1.62 per 1 degrees C) and throat symptoms (OR = 1.53 per 1 degrees C), headache (OR = 1.51 per 1 degrees C) and tiredness (OR = 1.54 per 1 degrees C) were significantly associated with temperature; headache was associated only with CO(2) (OR = 1.19 per 100 ppm CO(2)). Longitudinal analysis demonstrated that increased room temperature was related to tiredness (P < 0.05). CONCLUSION: Computer classrooms may have CO(2) above 1,000 ppm and temperatures above 22 degrees C. Increased temperature and CO(2) may affect mucosal membrane symptoms, headaches and tiredness. Room temperature was most important. CO(2) associations may partly be temperature effects.
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| 9. |
- Nordström, Klas, et al.
(författare)
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Effect of Air Humidification on the Sick Building Syndrome and Perceived Indoor Air Quality in Hospitals: a Four Month Longitudinal Study
- 1994
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Ingår i: Occupational and Environmental Medicine. - : BMJ. - 1470-7926 .- 1351-0711. ; 51:10, s. 683-688
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Tidskriftsartikel (refereegranskat)abstract
- The sensation of dryness and irritation is essential in the sick building syndrome (SBS), and such symptoms are common in both office and hospital employees. In Scandinavia, the indoor relative humidity in well ventilated buildings is usually in the range 10-35% in winter. The aim of this study was to evaluate the effect of steam air humidification on SBS and perceived air quality during the heating season. The study base consisted of a dynamic population of 104 hospital employees, working in four new and well ventilated geriatric hospital units in southern Sweden. Air humidification raised the relative air humidity to 40-45% in two units during a four months period, whereas the other two units served as controls with relative humidity from 25-35%. Symptoms and perceived indoor air quality were measured before and after the study period by a standardised self administered questionnaire. The technical measurements comprised room temperature, air humidity, static electricity, exhaust air flow, aerosols, microorganisms, and volatile organic compounds in the air. The most pronounced effect of the humidification was a significant decrease of the sensation of air dryness, static electricity, and airway symptoms. After four months of air humidification during the heating season, 24% reported a weekly sensation of dryness in humidified units, compared with 73% in controls. No significant changes in symptoms of SBS or perceived air quality over time were found in the control group. The room temperature in all units was between 21-23 degrees C, and no significant effect of air humidification on the air concentration of aerosols or volatile organic compounds was found. No growth of microorganisms was found in the supply air ducts, and no legionella bacteria were found in the supply water of the humidifier. Air humidification, however, significantly reduced the measured personal exposure to static electricity. It is concluded that air humidification during the heating season in colder climates can decrease symptoms of SBS and perception of dry air.
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| 10. |
- Nordström, Klas
(författare)
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Indoor environment and air quality in hospital units : Symptoms and signs
- 1999
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Indoor environment may influence the occurrence of symptoms such as eye, skin and upper airway irritation, headache and fatigue. The aim of the dissertation was to study relations between subjective indoor air quality, such symptoms, clinical signs from the nose and the eyes and the physical indoor environment, in particular the effect of dampness, type of building, and air humidification. The studies were performed in geriatric hospital units in southern Sweden. The technical investigations comprised a building survey and measurements of indoor air factors, including building dampness in the floor construction. Subjective indoor air quality, and symptoms were related to both personal factors, building characteristics, and the indoor environment. Perception of stuffy air and odour was more common in poorly ventilated buildings. Eye irritation and dry facial skin were more common in new buildings. Air humidification reduced the perception of dry air, static electricity and throat symptoms.Headache, fatigue, reduced tear film break up time (BUT), increased lysozyme concentration in nasal lavage and symptoms from the eye, nose and throat were more common in damp buildings with emission of 2-etyl-1-hexanol, and related to measured dampness and ammonia in the floor.Complaints on air dryness and stuffy air were more common in damp buildings. The hospital workers in a new building with special design, built by an anthroposophic society, had less complaints on perceived air and symptoms, and increased BUT. It is concluded that symptoms and complaints on air quality are common among hospital workers, and related to measurable environmental factors, psychosocial climate and personal factors. Our results indicate that measurement of biomarkers in nasal lavage, and measurement of tear film stability, could be useful tools to study human reactions to the indoor environment. From a preventive point of view, to create healthy buildings, the physical and psychosocial climate must be satisfactory, building dampness should be avoided, room temperature should be 20-22 °C. Subjective air quality and the occurrence of symptoms may also be influenced by selection of building materials, building design and air humidification.
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