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| 2. |
- Dyal Ukabhai, K., et al.
(författare)
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Formation of Ti2Cu in Ti-Cu Alloys
- 2022
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Ingår i: JOURNAL OF PHASE EQUILIBRIA AND DIFFUSION. - : Springer Nature. - 1547-7037 .- 1863-7345. ; 43:3, s. 332-344
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Tidskriftsartikel (refereegranskat)abstract
- One of the major issues with dental implants is failure due to bacterial infection, and additions of copper are known to improve the antimicrobial properties of Ti alloys. There are inconsistencies in the Ti rich area of the Cu-Ti binary phase diagram, hence the need to find out if Ti2Cu or Ti3Cu is formed, and to identify the type of formation of Ti2Cu. Four alloys: 20, 33, 40 and 50 Cu (mass%) were produced by arc melting and studied using SEM, XRD and DSC. The reactions were derived, and the temperatures of the reactions were determined by DSC. The formation of Ti2Cu is congruent, and no Ti3Cu was found.
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| 3. |
- Halliday, Alison, et al.
(författare)
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10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1) : A multicentre randomised trial
- 2010
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 376:9746, s. 1074-1084
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Tidskriftsartikel (refereegranskat)abstract
- Background If carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA. Methods Between 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were allocated equally, by blinded minimised randomisation, to immediate CEA (median delay 1 month, IQR 0·3-2·5) or to indefinite deferral of any carotid procedure, and were followed up until death or for a median among survivors of 9 years (IQR 6-11). The primary outcomes were perioperative mortality and morbidity (death or stroke within 30 days) and non-perioperative stroke. Kaplan-Meier percentages and logrank p values are from intention-to-treat analyses. This study is registered, number ISRCTN26156392. Findings 1560 patients were allocated immediate CEA versus 1560 allocated deferral of any carotid procedure. The proportions operated on while still asymptomatic were 89·7 versus 4·8 at 1 year (and 92·1 vs 16·5 at 5 years). Perioperative risk of stroke or death within 30 days was 3·0 (95 CI 2·4-3·9; 26 non-disabling strokes plus 34 disabling or fatal perioperative events in 1979 CEAs). Excluding perioperative events and non-stroke mortality, stroke risks (immediate vs deferred CEA) were 4·1 versus 10·0 at 5 years (gain 5·9, 95 CI 4·0-7·8) and 10·8 versus 16·9 at 10 years (gain 6·1, 2·7-9·4); ratio of stroke incidence rates 0·54, 95 CI 0·43-0·68, p<0·0001. 62 versus 104 had a disabling or fatal stroke, and 37 versus 84 others had a non-disabling stroke. Combining perioperative events and strokes, net risks were 6·9 versus 10·9 at 5 years (gain 4·1, 2·0-6·2) and 13·4 versus 17·9 at 10 years (gain 4·6, 1·2-7·9). Medication was similar in both groups; throughout the study, most were on antithrombotic and antihypertensive therapy. Net benefits were significant both for those on lipid-lowering therapy and for those not, and both for men and for women up to 75 years of age at entry (although not for older patients). Interpretation Successful CEA for asymptomatic patients younger than 75 years of age reduces 10-year stroke risks. Half this reduction is in disabling or fatal strokes. Net benefit in future patients will depend on their risks from unoperated carotid lesions (which will be reduced by medication), on future surgical risks (which might differ from those in trials), and on whether life expectancy exceeds 10 years. Funding UK Medical Research Council, BUPA Foundation, Stroke Association.
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| 5. |
- Shahim, Pashtun, 1984, et al.
(författare)
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Serum neurofilament light protein predicts clinical outcome in traumatic brain injury
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Axonal white matter injury is believed to be a major determinant of adverse outcomes following traumatic brain injury (TBI). We hypothesized that measurement of neurofilament light protein (NF-L), a protein found in long white-matter axons, in blood samples, may serve as a suitable biomarker for neuronal damage in TBI patients. To test our hypotheses, we designed a study in two parts: i) we developed an immunoassay based on Single molecule array technology for quantification of NF-L in blood, and ii) in a proof-of-concept study, we tested our newly developed method on serial serum samples from severe TBI (sTBI) patients (n = 72) and controls (n = 35). We also compared the diagnostic and prognostic utility of NF-L with the established blood biomarker S100B. NF-L levels were markedly increased in sTBI patients compared with controls. NF-L at admission yielded an AUC of 0.99 to detect TBI versus controls (AUC 0.96 for S100B), and increased to 1.00 at day 12 (0.65 for S100B). Importantly, initial NF-L levels predicted poor 12-month clinical outcome. In contrast, S100B was not related to outcome. Taken together, our data suggests that measurement of serum NF-L may be useful to assess the severity of neuronal injury following sTBI.
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| 6. |
- Dalarsson, Mariana, et al.
(författare)
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Gradient index metamaterial with arbitrary loss factors in RHM and LHM media : The case of constant impedance throughout the structure
- 2012
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Ingår i: PIERS 2012 Moscow. - : Electromagnetics Academy. - 9781934142226 ; , s. 1390-1394
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Konferensbidrag (refereegranskat)abstract
- The transmission and reflection properties of lossy structures involving left-handed materials with graded permittivity and permeability have been investigated. We present an exact analytical solution to Helmholtz' equation for a lossy case with the graded both real and imaginary parts of permittivity and permeability profile changing according to a hyperbolic tangent function along the direction of propagation. This allows for different loss factors in the two media. The expressions and graphical results for the field intensity along the graded structure are presented. The analytical solution is validated by a dispersive numerical model of lossy metamaterials that uses a transmission line matrix method based on Z-transforms, where a close agreement between the analytic and numerical results is obtained.
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| 7. |
- Dalarsson, Mariana, et al.
(författare)
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Lossy gradient index transmission optics with arbitrary periodic permittivity and permeability and constant impedance throughout the structure
- 2012
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Ingår i: Journal of Optics. - : IOP Publishing. - 2040-8978 .- 2040-8986. ; 14:6, s. 065102-
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Tidskriftsartikel (refereegranskat)abstract
- A remarkably simple exact analytical solution is obtained for the electromagnetic field distribution across infinite metamaterial-containing composites with any arbitrary periodic variation of complex effective permittivity and permeability for the case of constant impedance across the structure. Arbitrary temporal dispersion and losses are allowed and the model is generally applicable to different inhomogeneous and anisotropic media simultaneously containing positive and negative refractive index constituents, as long as the effective medium approximation remains valid. The analytical solution is validated by a dispersive numerical model of lossy metamaterials that uses a transmission line matrix method based on Z-transforms, where a close agreement between the analytic and numerical results is obtained.
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| 8. |
- Dalarsson, Mariana, et al.
(författare)
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Lossy transmision with arbitrary gradient permittivity and permeability and constant impedance throughout the structure
- 2013
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Ingår i: 2013 11th International Conference on Telecommunications in Modern Satellite, Cable and Broadcasting Services, TELSIKS 2013. - : IEEE. - 9781479909025 ; , s. 25-28
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Konferensbidrag (refereegranskat)abstract
- We present a remarkably simple exact analytical solution for the electromagnetic field distribution across an infinite metamaterial composite with an arbitrary graded variation of complex effective permittivity and permeability for the case of constant impedance across the structure. Arbitrary temporal dispersion and losses are allowed and the model is generally applicable to different inhomogeneous and anisotropic media simultaneously containing positive and negative refractive index constituents, as long as the effective medium approximation remains valid. The analytical solution is validated by a dispersive numerical model of lossy metamaterials that uses a transmission line matrix method based on Z-transforms, where a close agreement between the analytic and numerical results is obtained.
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| 9. |
- Dekki, N, et al.
(författare)
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Type 1 diabetic serum interferes with pancreatic beta-cell Ca2+-handling
- 2007
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Ingår i: Bioscience reports. - : Portland Press Ltd.. - 0144-8463 .- 1573-4935. ; 27:6, s. 321-326
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to clarify the frequency of patients with type 1 diabetes that have serum that increases pancreatic β-cell cytoplasmic free Ca2+ concentration, [Ca2+]i, and if such an effect is also present in serum from first-degree relatives. We also studied a possible link between the serum effect and ethnic background as well as presence of autoantibodies. Sera obtained from three different countries were investigated as follows: 82 Swedish Caucasians with newly diagnosed type 1 diabetes, 56 Americans with different duration of type 1 diabetes, 117 American first-degree relatives of type 1 diabetic patients with a mixed ethnic background and 31 Caucasian Finnish children with newly diagnosed type 1 diabetes. Changes in [Ca2+]i, upon depolarization, were measured in β-cells incubated overnight with sera from type 1 diabetic patients, first-degree relatives or healthy controls. Our data show that there is a group constituting approximately 30% of type 1 diabetic patients of different gender, age, ethnic background and duration of the disease, as well as first-degree relatives of type 1 diabetic patients, that have sera that interfere with pancreatic β-cell Ca2+-handling. This effect on β-cell [Ca2+]i could not be correlated to the presence of autoantibodies. In a defined subgroup of patients with type 1 diabetes and first-degree relatives a defect Ca2+-handling may aggravate development of β-cell destruction.
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