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- 2019
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Tidskriftsartikel (refereegranskat)
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- Benoît, Catherine, et al.
(författare)
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The Guidelines for Social Life Cycle Assessment of products: Just in time!
- 2010
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Ingår i: The International Journal of Life Cycle Assessment. - : Springer Science and Business Media LLC. - 0948-3349 .- 1614-7502. ; 15:2, s. 156-163
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Authors of different sustainability journals, including authors of articles in past issues of the International Journal of Life Cycle Assessment have acknowledged the rising interest and the pressing need for a social and socio-economic life cycle assessment methodology and identified challenges in its development and implementation. Social life cycle assessment (LCA) allows identification of key issues, assessing, and telling the story of social conditions in the production, use, and disposal of products. In this article, the United Nations Environment Programme/The Society of Environmental Toxicology and Chemistry Guidelines for Social Life Cycle Assessment of Products will be presented. Aim and scope The guidelines demystifies the assessment of product life cycle social impacts and presents an effective framework representing the consensus of an international group of experts leading research in this field. The guidelines complement those for environmental life cycle assessment and life cycle costing, and by doing so contribute to the full assessment of goods and services within the context of sustainable development. They enable a larger group of stakeholders to engage. Key aspects of the framework and the research needs identified in the guidelines will be summarized. Conclusions In a globalized world where transparency and information occupies a predominant place and where consumers and companies reach out to shed light on both the brightest and the darkest side of the economy and, when applicable, transform its condition, social LCA brings strong value. At a moment where major companies and initiatives are going forward with using LCA and are trying to track and communicate about the social impacts of their products they are increasingly held accountable for the guidelines for social life cycle assessment arrive just in time to inform their efforts.
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- Briem, Valdimar, et al.
(författare)
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Train drivers and fatal accidents on the rail: Psychological aspects and safety
- 2007
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Ingår i: People and Rail Systems: Human Factors at the Heart of the Railway. - 0754671844 - 9780754671848
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Psychological disability caused by stress is likely to affect cognitive and emotional functions, such as memory, attention, concentration, and decision making. These functions are essential in a train driver’s work, who is responsible for his or her own and others’ safety, and for this purpose requires optimal work capacity. Eighteen train drivers, 40 – 56 years old, most of them with long work experience, participated in the present study, which included psychological tests and interviews concerning fatal railway accidents the driver had experienced while at the controls of the train. The results indicate that a train driver who has witnessed a person being killed under his or her train frequently suffers long-lasting psychological consequences of the accident. It is evident that careful measures, which include professional psychological help and support from the driver’s family, peers, and company management, are important components in the psychological healing process after such an accident.
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- Christakoudi, Sofia, et al.
(författare)
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Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy
- 2020
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Ingår i: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 58
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Tidskriftsartikel (refereegranskat)abstract
- Background: Kidney transplant recipients (KTRs) with "operational tolerance" (OT) maintain a functioning graft without immunosuppressive (IS) drugs, thus avoiding treatment complications. Nevertheless, IS drugs can influence gene-expression signatures aiming to identify OT among treated KTRs. Methods: We compared five published signatures of OT in peripheral blood samples from 18 tolerant, 183 stable, and 34 chronic rejector KTRs, using gene-expression levels with and without adjustment for IS drugs and regularised logistic regression. Findings: IS drugs explained up to 50% of the variability in gene-expression and 20-30% of the variability in the probability of OT predicted by signatures without drug adjustment. We present a parsimonious consensus gene-set to identify OT, derived from joint analysis of IS-drug-adjusted expression of five published signature gene-sets. This signature, including CD40, CTLA4, HSD11B1, IGKV4-1, MZB1, NR3C2, and RAB40C genes, showed an area under the curve 0.92 (95% confidence interval 0.88-0.94) in cross-validation and 0.97 (0.93-1.00) in six months follow-up samples. Interpretation: We advocate including adjustment for IS drug therapy in the development stage of gene-expression signatures of OT to reduce the risk of capturing features of treatment, which could be lost following IS drug minimisation or withdrawal. Our signature, however, would require further validation in an independent dataset and a biomarker-led trial. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/)
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| 6. |
- Christakoudi, Sofia, et al.
(författare)
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Steroid regulation : An overlooked aspect of tolerance and chronic rejection in kidney transplantation
- 2018
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Ingår i: Molecular and Cellular Endocrinology. - : ELSEVIER IRELAND LTD. - 0303-7207 .- 1872-8057. ; 473, s. 205-216
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Tidskriftsartikel (refereegranskat)abstract
- Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (n = 17), stable (n = 190) and CR patients (n = 37) were compared. Healthy controls (n= 14) were used as reference. The anti-inflammatory glucocorticoid receptor (NR3C1) and the cortisol-activating HSD11B1 and H6PD genes were up-regulated in CR and were lowest in tolerant patients. The pro-inflammatory mineralocorticoid gene (NR3C2) was downregulated in stable and CR patients. NR3C1 was associated with neutrophils and NR3C2 with T-cells. Steroid conversion and receptor genes, alone, enabled classification of tolerant patients and were major contributors to gene-expression signatures of both, tolerance and CR, alongside known tolerance-associated genes, revealing a key role of steroid regulation and response in kidney transplantation.
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