| 1. |
- Hommel, Ami, et al.
(författare)
-
Influence of optimised treatment of people with hip fracture on time to operation, length of hospital stay, reoperations and mortality within 1 year
- 2008
-
Ingår i: Injury. - : Elsevier. - 0020-1383 .- 1879-0267. ; 39:10, s. 1164-1174
-
Tidskriftsartikel (refereegranskat)abstract
- Hip fractures are a major cause of hospital stay among the elderly, and result in increased disability and mortality. In this study from 1 April 2003 to 31 March 2004, the influence of optimised treatment of hip fracture on time to operation, length of hospital stay, reoperations and mortality within 1 year were investigated. Comparisons were made between the first 210 patients in the period and the last 210 patients, who followed the new clinical pathway introduced at the University Hospital in Lund, Sweden. Early surgery, within 24h, was not associated with reduced mortality, but was significantly associated with reduced length of stay (p<0.001). Significantly more cases of osteosynthesis for femoral neck fracture were reoperated compared with all other types of surgery (p<0.001) when reoperations with extraction of the hook pins in healed fractures were excluded. Mortality was significantly higher among men than women at 4 (p=0.025) and 12 (p=0.001) months after fracture and among medically fit patients with administrative delay to surgery compared with patients with no delay (p<0.001).
|
|
| 2. |
- Nordström, Peter, et al.
(författare)
-
Geriatric Rehabilitation and Discharge Location After Hip Fracture in Relation to the Risks of Death and Readmission
- 2016
-
Ingår i: Journal of the American Medical Directors Association. - : Elsevier. - 1525-8610 .- 1538-9375. ; 17:1
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To investigate the effects of geriatric rehabilitation on short-term risk of death and readmission after a hip fracture were investigated in a nationwide cohort. In addition, the association of discharge location (nursing home or patient's home) with the short-term risk of death was assessed.DESIGN, SETTING, AND PARTICIPANTS: The cohort consisted of 89,301 individuals at least 50 years of age, with a first hip fracture registered in the Swedish quality register RIKSHÖFT, the years 2004-2012.MEASURES: Short-term risk of death and readmission to hospital after discharge was compared at 8 hospitals, where most patients received inpatient care in geriatric wards, and those treated at 71 regular hospitals.RESULTS: The risks of death within 30 days of admission were 7.1% in patients admitted to geriatric ward hospitals and 7.4% in those treated at regular hospitals (multivariable-adjusted hazard ratio [HR] 0.91, 95% CI 0.85-0.97), whereas the odds of readmission within 30 days of discharge were 8.7% and 9.8%, respectively (multivariable-adjusted odds ratio 0.86, 95% CI 0.81-0.91). The risk of death was influenced by discharge location and inpatient length of stay (LOS). Thus, for patients discharged to short-term nursing homes with a LOS of at most 10 days, each additional day of LOS reduction increased the risk of death within 30 days of discharge by 13% (HR 1.13, 95% CI 1.08-1.18). This association was reduced in patients discharged to permanent nursing homes (HR 1.04, 95% CI 1.02-1.07), and not significant in those discharged to their own home (OR 1.00, 95% CI 0.91-1.10).CONCLUSION: The risks of death and readmission were lower in patients with hip fracture who received care in hospitals with geriatric wards. The risk of death after discharge increased with shorter LOS, especially in patients discharged to short-term nursing homes.
|
|
| 3. |
- Andersson, Malte, 1941, et al.
(författare)
-
”Minskande befolkning är inte problemet”
- 2020
-
Ingår i: Dagens Nyheter. ; :1 augusti, DN-debatt
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Nätverket Population Matters Sweden: En uppmärksammad studie i The Lancet pekar mot en lägre befolkningsökning i världen än tidigare prognoser. Men en miljard människor till är fortfarande långt över vad jorden klarar. Befolkningstrenden måste snarare vända neråt, och det kräver åtgärder för att stärka kvinnors rättigheter världen över.
|
|
| 4. |
- Bank, Natasha, 1983-
(författare)
-
Sustainability-Oriented Business Incubators
- 2020
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis explores the attraction, selection, and support in sustainability-oriented business incubators. Business incubators as hatcheries for start-ups are considered key tools to enhance job creation and strengthen regional economies. While the world population grows and consumption of natural resources increases, the ecosystem services decline. If these issues are not properly addressed, the economic, social, and environmental pressures that are growing in our societies will lead to disasters and threats to humankind. Green incubators can implement sustainability thinking and the related principles in the start-up community right from the beginning, and hence play a significant role in reorienting start-up businesses towards sustainability.This study shows the importance of making business incubators better known to their potential clients in order to increase visibility and attract more green tenants. The sustainability-oriented business incubators (SOBI), to have a better selection of tenants, need to attract more sustainable entrepreneurs in the first place. Moreover, the selection criteria affect the in-house atmosphere of the incubator, which in turn affects the attraction of more like-minded tenants to the incubator. In addition, word of mouth through partners and referrals by successfully graduated tenants, as well as expert management teams including coaches and consultants and their related networks and mediations, exert more influence on the attraction. In other words, the attraction is dependent both on the selection criteria and the support given to the tenants. To attract proper tenants, a rich local environment, regional and inter-regional collaboration, a well-planned, well-structured pre-incubation process, and credibility of incubators with managerial sustainability expertise and well-established networks are also essential.When it comes to the selection processes, different factors affect the selection criteria, including business incubators’ goal and agenda such as job creation, diversification of the local economy, utilization of vacant property, commercialization of research, investment as well as owner and sponsors (including public and private), physical characters such as age, size, and occupancy rates. Furthermore, incubators might have different selection strategies such as rigorous-vs-flexible as well as entrepreneur-vs-idea priorities. The initial ambition of SOBIs is to select business ideas that are primarily geared towards sustainability. However, the empirical data has shown that it is not always achievable to attract a sufficient number of green tenants to meet those criteria. The challenges, for example, could be due to economic cycles, specialization, and high-bar (i.e., eligibility) criteria, location limits, lack of sustainable-minded entrepreneurs, and the like.In recent years, increased awareness about sustainability issues and the UN Sustainable Development Goals (SDGs), as well as signals from green financiers, business owners, and other stakeholders, have forced many incubators to adjust their selection criteria to match sustainability requirements. However, empirical results show that the support given to tenants in green incubators has not been different from conventional ones. But more recently (especially during the past two-three years), institutional forces and the need for more legitimacy have led more and more incubators (even conventional ones) to change their mindset and provide more support towards sustainable business ideas. The conclusions of this study imply that business incubators need to strive for making sustainable entrepreneurs, not selecting them. In order to provide comprehensive sustainability-oriented support, SOBIs need to recruit sustainability experts and educate management teams as well as their tenants about sustainability issues.
|
|
| 5. |
- Ben Henda, Noomene, et al.
(författare)
-
OpenSAW: Open Security Analysis Workbench
- 2017. - 1
-
Ingår i: Fundamental Approaches to Software Engineering : 20th International Conference, FASE 2017, Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2017, Uppsala, Sweden, April 22-29, 2017, Proceedings - 20th International Conference, FASE 2017, Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2017, Uppsala, Sweden, April 22-29, 2017, Proceedings. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783662544938 - 9783662544945 ; 10202, s. 321-337
-
Konferensbidrag (refereegranskat)abstract
- Software is today often composed of many sourced components, which potentially contain security vulnerabilities, and therefore require testing before being integrated. Tools for automated test case generation, for example, based on white-box fuzzing, are beneficial for this testing task. Such tools generally explore limitations of the specific underlying techniques for solving problems related to, for example, constraint solving, symbolic execution, search heuristics and execution trace extraction. In this article we describe the design of OpenSAW, a more flexible general-purpose white-box fuzzing framework intended to encourage research on new techniques identifying security problems. In addition, we have formalized two unaddressed technical aspects and devised new algorithms for these. The first relates to generalizing and combining different program exploration strategies, and the second relates to prioritizing execution traces. We have evaluated OpenSAW using both in-house and external programs and identified several bugs.
|
|
| 6. |
- Curtin, Paul, et al.
(författare)
-
Associations between Elemental Metabolic Dynamics and Default Mode Network Functional Connectivity Are Altered in Autism.
- 2023
-
Ingår i: Journal of clinical medicine. - : MDPI. - 2077-0383. ; 12:3
-
Tidskriftsartikel (refereegranskat)abstract
- Autism is a neurodevelopmental condition associated with atypical social communication, cognitive, and sensory faculties. Recent advances in exposure biology suggest that biomarkers of elemental uptake and metabolism measured in hair samples can yield an effective signal predictive of autism diagnosis. Here, we investigated if elemental biomarkers in hair were associated with functional connectivity in regions of the default mode network (DMN) previously linked to autism. In a study sample which included twin pairs with concordant and discordant diagnoses for autism, our analysis of hair samples and neuroimaging data supported two general findings. First, independent of autism diagnosis, we found a broad pattern of association between elemental biomarkers and functional connectivity in the DMN, which primarily involved dynamics in zinc metabolism. Second, we found that associations between the DMN and elemental biomarkers, particularly involving phosphorus, calcium, manganese, and magnesium, differed significantly in autistic participants from control participants. In sum, these findings suggest that functional dynamics in elemental metabolism relate broadly to persistent patterns of functional connectivity in the DMN, and that these associations are altered in the emergence of autism.
|
|
| 7. |
- Derer, Patricia, et al.
(författare)
-
”Bryt tabun kring folkökning och klimatet”
- 2020
-
Ingår i: Svenska Dagbladet. ; :25 September
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Folkökning och ekonomisk expansion är de främsta drivkrafterna bakom utsläpp av växthusgaser, fastslog FN:s klimatpanel 2014 (IPCC). Men klimatarbetet är i stort begränsat till konsumtionsreglering och teknisk utveckling med delvis okänd effektivitet. Klimatvinster av långsammare folkökning ignoreras nästan helt av forskare, media, och politiker. I en ny kunskapsöversikt i Science of the Total Environment klargör vi fördelar som kan uppnås med ett bättre integrerat klimatarbete.
|
|
| 8. |
- Dumitriu, Dani, et al.
(författare)
-
Deciduous tooth biomarkers reveal atypical fetal inflammatory regulation in autism spectrum disorder.
- 2023
-
Ingår i: iScience. - : Cell Press. - 2589-0042. ; 26:3
-
Tidskriftsartikel (refereegranskat)abstract
- Atypical regulation of inflammation has been proposed in the etiology of autism spectrum disorder (ASD); however, measuring the temporal profile of fetal inflammation associated with future ASD diagnosis has not been possible. Here, we present a method to generate approximately daily profiles of prenatal and early childhood inflammation as measured by developmentally archived C-reactive protein (CRP) in incremental layers of deciduous tooth dentin. In our discovery population, a group of Swedish twins, we found heightened inflammation in the third trimester in children with future ASD diagnosis relative to controls (n = 66; 14 ASD cases; critical window: -90 to -50 days before birth). In our replication study, in the US, we observed a similar increase in CRP in ASD cases during the third trimester (n = 47; 23 ASD cases; -128 to -21 days before birth). Our results indicate that the third trimester is a critical period of atypical fetal inflammatory regulation in ASD.
|
|
| 9. |
- Franklin, Karl, et al.
(författare)
-
Early life environment and snoring in adulthood
- 2008
-
Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921 .- 1465-993X. ; 9:1, s. 63-
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: To our knowledge, no studies of the possible association of early life environment with snoring in adulthood have been published. We aimed to investigate whether early life environment is associated with snoring later in life. METHODS: A questionnaire including snoring frequency in adulthood and environmental factors in early life was obtained from 16,190 randomly selected men and women, aged 25-54 years, in Sweden, Norway, Iceland, Denmark and Estonia (response rate 74%). RESULTS: A total of 15,556 subjects answered the questions on snoring. Habitual snoring, defined as loud and disturbing snoring at least 3 nights a week, was reported by 18%. Being hospitalized for a respiratory infection before the age of two years (adjusted odds ratio (OR) = 1.27; 95% confidence interval (CI) 1.01-1.59), suffering from recurrent otitis as a child (OR = 1.18; 95%CI 1.05-1.33), growing up in a large family (OR = 1.04; 95%CI 1.002-1.07) and being exposed to a dog at home as a newborn (OR = 1.26; 95%CI 1.12-1.42) were independently related to snoring later in life and independent of a number of possible confounders in adulthood. The same childhood environmental factors except household size were also related with snoring and daytime sleepiness combined. CONCLUSION: The predisposition for adult snoring may be partly established early in life. Having had severe airway infections or recurrent otitis in childhood, being exposed to a dog as a newborn and growing up in a large family are environmental factors associated with snoring in adulthood.
|
|
| 10. |
- Fälth, Maria, et al.
(författare)
-
SwePep – A database designed for endogenous peptides and mass spectrometry
- 2006
-
Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 5:6, s. 998-1005
-
Tidskriftsartikel (refereegranskat)abstract
- A new database, SwePep, specifically designed for endogenous peptides, has been constructed to significantly speed up the identification process from complex tissue samples utilizing mass spectrometry. In the identification process the experimental peptide masses are compared with the peptide masses stored in the database both with and without possible post-translational modifications. This intermediate identification step is fast and singles out peptides that are potential endogenous peptides and can later be confirmed with tandem mass spectrometry data. Successful applications of this methodology are presented. The SwePep database is a relational database developed using MySql and Java. The database contains 4180 annotated endogenous peptides from different tissues originating from 394 different species as well as 50 novel peptides from brain tissue identified in our laboratory. Information about the peptides, including mass, isoelectric point, sequence, and precursor protein, is also stored in the database. This new approach holds great potential for removing the bottleneck that occurs during the identification process in the field of peptidomics. The SwePep database is available to the public.
|
|
