| 1. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 2. |
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| 3. |
- Notta-Cuvier, D., et al.
(författare)
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An efficient modelling of inelastic composites with misaligned short fibres
- 2013
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Ingår i: International Journal of Solids and Structures. - : Pergamon Press. - 0020-7683 .- 1879-2146. ; 50:19, s. 2857-2871
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Tidskriftsartikel (refereegranskat)abstract
- This paper deals with the modelling of the behaviour of short-fibre reinforced composites. The composite is seen as an assembly of a matrix medium and of several fibre media. Each fibre medium, characterised by its own orientation of fibres and volume fraction, is considered as a one-dimensional elastic medium. The matrix material has an elastoplastic behaviour. All types of hardening laws can be considered, thanks to a valuable adaptivity of the modelling. The use of the Drucker-Prager criterion for plasticity and non-associative plasticity rules allow to deal with compressible plastic flow. Moreover, all kind of orientation of fibres, in particular random orientations and imperfect alignments, can be modelled in a simple way. The influence of the fibres' orientation on the mechanical response of a polymer matrix composite subjected to tensile/compression tests is analysed in detail. Finally, simulated behaviours of composites are compared to experimental data found in the literature.
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| 4. |
- Notta-Cuvier, D., et al.
(författare)
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Damage of short-fibre reinforced materials with anisotropy induced by complex fibres orientations
- 2014
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Ingår i: Mechanics of materials. - : Elsevier. - 0167-6636 .- 1872-7743. ; 68, s. 193-206
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, a behaviour model for damageable elastoplastic materials reinforced with short fibres that have complex orientations is. proposed. The composite material is seen as the assembly of the matrix medium and several linear elastic fibre media. Its macroscopic behaviour is computed thanks to an additive decomposition of the state potential, with no need to implement complex methods of homogenisation. A 4th-order tensor that depends on the characteristics of each fibre medium is introduced to model the anisotropic damage of the matrix material induced by the reinforcement, as well as the progressive degradation of the fibre-matrix interface. The division of short fibres into several families means that complex distributions of orientation or random orientation can be easily modelled. The model is tested for the case of a polyamide reinforced with different contents of short-glass fibres with distributed orientations and subjected to uniaxial tensile tests in different loading directions. The comparison of the results with experimental data (extracted from the literature) demonstrates the efficiency of the model.
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